Incidence and risk factors for hepatitis C infection in a cohort of women in rural Egypt

Saleh, Doa’a A.; Shebl, Fatma M.; Abdel‐Hamid, Mohamed; Narooz, Shaker; Mikhail, Nabiel; El-Batanony, Manal; El-Kafrawy, Sherif A.; El-Daly, Maï; Sharaf, Soraya; Hashem, Mohamed; El-Kamary, Samer S.; Magder, Laurence S.; Stoszek, Sonia K.; Strickland, G. Thomas

doi:10.1016/j.trstmh.2008.04.011

Cited by 64 publications

(44 citation statements)

References 27 publications

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“…These results show that a large proportion of infants were only temporarily positive for HCV-RNA during the first weeks of life and the PCR test should be repeated again at 6 months of life. Studies that do not test infants when they are older may lead to overestimates of HCV prevalence and this may be the case with community-based study of perina-tal HCV transmission in 3 rural Egyptian villages, where the overall HCV prevalence of more than 20% was found (5,(22)(23)(24).…”

Section: Mother-to-infant Transmission For Hcvmentioning

confidence: 99%

Prospective Study of Prevalence and Risk Factors for Hepatitis C in Pregnant Egyptian Women and Its Transmission to Their Infants

et al. 2010

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Aim To estimate the hepatitis C virus (HCV) vertical transmission rate, the effect of potential risk factors, and the pattern of HCV antibody response and viremia in HCV-infected infants in Benha, Egypt.Methods A total of 1224 pregnant women who were treated at Benha University Hospital, Egypt, were included in the study. They completed a questionnaire about risk factors for HCV acquisition and suspected risk factors for mother-to-infant transmission and were tested for HCV antibody using a third-generation ELISA test. Women positive for HCV antibody were tested for HCV RNA by polymerase chain reaction. Peripheral blood of infants of positive HCV-RNA women was tested for HCV antibody and HCV-RNA at 1 and after 6 months of age.Results Out of 1224 pregnant women, 105 (8.6%; 95% confidence interval, 7.05-10.17) were positive for HCV antibody. Only 83 (6.8%; 5.39-7.21) were positive for HCV-RNA. HCV infection was associated with older age (1.16; 1.1-1.2, P = 0.001), blood transfusion (2.69; 1.2-6.0, P = 0.016), and HCV infection of the husband (5.47; 1.4-21, P = 0.014) or other household members (2.29; 1.2-4.6, P = 0.019). Out of 53 infants tested at first month, 43 (81%; 71-92%) were positive for HCV antibody, but only 7 (13%; 4.1-22%) were positive for HCV-RNA. After 6 months, only 2 (3.8%; 0-8.95%) remained positive for HCV RNA. ConclusionsThe prevalence of HCV in pregnant women in Egypt is lower than previously reported and the potential risk factors associated with HCV infection suggest intra-familial transmission. The frequency of vertical transmission of HCV in Egypt is not substantially different from other countries and does not play a role in the high prevalence of HCV in Egypt. CLINICAL SCIENCES doi: 10.3325/cmj.2010.51.219 CLINICAL SCIENCE 220Croat Med J. 2010; 51: 219-28 www.cmj.hrWorldwide, hepatitis C virus (HCV) infection is one of the most prevalent causes of liver diseases. There are estimated 300 million carriers of the virus all over the world (1). In the USA, the overall prevalence of HCV antibodies in the general population is 1.8%, the prevalence in children 6-11 years is 0.2%, and in adolescents 12-19 years old is 0.4% (2). In most developed countries, HCV infection is associated with percutaneous blood exposure, primarily as a result of blood transfusion and intravenous drug addiction (3).Egypt has the highest prevalence of hepatitis C in the world. Studies have found widely varying levels (10-50%) of the prevalence, depending on the populations covered; overall, estimates of the HCV rate in the general population range between 10 and 20% (4,5). Geographically, hepatitis C prevalence is higher in Lower Egypt (Nile delta) than Upper Egypt, and it is lower in urban than rural areas (6).In Egypt, the use of contaminated needles and syringes during mass schistosomiasis treatment campaigns during the period the 1960s-1980s has been identified as a key mode of transmission for HCV infection, suggesting that parenteral exposure continues to cause infections (7). Evidence of high interfamili...

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Section: Mother-to-infant Transmission For Hcvmentioning

confidence: 99%

Prospective Study of Prevalence and Risk Factors for Hepatitis C in Pregnant Egyptian Women and Its Transmission to Their Infants

et al. 2010

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“…Its genome consists of~10 000 nt and encodes a single polyprotein of 3000 aa. HCV infection is one of the leading causes of chronic liver disease worldwide, and the World Health Organization has estimated that over 170 million people globally are infected with HCV, an incidence of 3.3 % of the world's population, with 3 million new cases each year (Alter, 2007;Sy & Jamal, 2006;Te & Jensen, 2010); in some countries, such as Egypt, the incidence is as high as 10-15 % (Saleh et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Inhibitory effects of native and recombinant full-length camel lactoferrin and its N and C lobes on hepatitis C virus infection of Huh7.5 cells

Liao

El-Fakkarany

Lönnerdal

et al. 2012

Journal of Medical Microbiology

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Lactoferrin has been suggested to have antiviral activity against hepatitis C virus (HCV). The objective of this study was to compare the effects of recombinant camel lactoferrin (rcLf), native camel lactoferrin (ncLf) and their N and C fragments on HCV infection in Huh7.5 cells. ncLf was purified from camel milk and N and C lobes were generated proteolytically. rcLf and its fragments were synthesized using a Bac-to-Bac baculovirus expression system. All proteins except the C lobe of rcLf were soluble. The inhibitory effects on HCV entry into Huh7.5 cells were evaluated by incubation of HCV with Lf prior to infection or pre-treatment of the cells with Lf prior to infection. The inhibitory effect on HCV amplification in Huh7.5 cells was determined by Lf treatment of HCV-infected cells. Nested RT-PCR was performed to amplify intracellular HCV 59 non-coding RNA sequences. rcLf and ncLf and their fragments could prevent HCV entry into Huh7.5 cells by direct interaction with the virus and inhibited virus amplification in Huh7.5 cells. Therefore, the N and C lobes of ncLf are sufficient to elicit anti-HCV effects in Huh7.5 cells. rcLf and its N lobe displayed similar HCV inhibitory effects to their native counterparts and may constitute an efficient and cost-effective approach for potential clinical applications.

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“…Liver damage is the one of the top deadliest disease in the world. The main causes of liver damage are Fatty liver, Liver Fibrosis, Cirrhosis, hepatitis and infections [2]. Fig 1. Shows the stages of liver damage, in the first stage healthy liver will become fatty liver due to accumulation of cholesterol and triglycerides, after few months to years fatty liver will becomes liver fibrosis, later it leads to final stage of liver damage known as cirrhosis.…”

Section: Introductionmentioning

confidence: 99%

Survey on machine learning algorithms for liver disease diagnosis and prediction

Kumar¹,

Sreedevi²,

Reddy³

2018

IJET

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Machine learning plays a vital role in health care industry. It is very important in Computer Aided Diagnosis. Computer Aided Diagnosis is a quickly developing dynamic region of research in medicinal industry. The current specialists in machine learning guarantee the enhanced precision of discernment and analysis of diseases. The computers are empowered to think by creating knowledge by learning. This procedure enables the computers to self-learn individually without being explicitly programed by the programmer .There are numerous sorts of Machine Learning Techniques and which are utilized to classify the data sets. They are Supervised, Unsupervised and Semi-Supervised, Reinforcement, deep learning algorithms. The principle point of this paper is to give comparative analysis of supervised learning algorithms in medicinal area and few of the techniques utilized as a part of liver disease prediction.

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Incidence and risk factors for hepatitis C infection in a cohort of women in rural Egypt

Cited by 64 publications

References 27 publications

Prospective Study of Prevalence and Risk Factors for Hepatitis C in Pregnant Egyptian Women and Its Transmission to Their Infants

Prospective Study of Prevalence and Risk Factors for Hepatitis C in Pregnant Egyptian Women and Its Transmission to Their Infants

Inhibitory effects of native and recombinant full-length camel lactoferrin and its N and C lobes on hepatitis C virus infection of Huh7.5 cells

Survey on machine learning algorithms for liver disease diagnosis and prediction

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