Incidence and remission of asthma: A retrospective study on the natural history of asthma in Italy

Marco, Roberto de; Locatelli, Francesca; Cerveri, Isa; Bugiani, Massimiliano; Marinoni, Alessandra; Giammanco, G

doi:10.1067/mai.2002.125600

Cited by 179 publications

(154 citation statements)

References 25 publications

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“…In EGEA, occupational exposure to asthmagens was associated with severe adult-onset asthma but not with mild asthma [5]. Asthma remission is very low in adults, and if the remission does not occur a few years after onset, the disease tends to become chronic [27,28]. Current adult-onset asthma is related to disability [29].…”

Section: Figurementioning

confidence: 99%

Occupational exposures and uncontrolled adult-onset asthma in the European Community Respiratory Health Survey II

Moual¹,

Carsin²,

Siroux³

et al. 2013

European Respiratory Journal

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Occupational exposure is a well-recognised modifiable risk factor for asthma, but the relationship between occupational exposure and asthma control has not been studied. We aimed to study this association among working-age adults from the European Community Respiratory Health Survey (ECRHS).Data were available for 7077 participants (mean age 43 years, 45% never-smokers, 5867 without asthma and 1210 with current asthma). Associations between occupational exposure to specific asthmagens and asthma control status (33% with uncontrolled asthma, based on the Global Initiative for Asthma guidelines) were evaluated using logistic and multinomial regressions, adjusted for age, sex and smoking status, with study areas included as a random effect.Statistically significant positive associations were observed between uncontrolled adult-onset asthma and both past 12-month and 10-year exposure to any occupational asthmagens (OR (95% CI) 1.6 (1.0-2.40) and 1.7 (1.2-2.5), respectively); high (1.7 (1.0-2.8) and 1.9 (1.3-2.9), respectively) and low (1.6 (1.0-2.7) and 1.8 (1.2-2.7), respectively) molecular weight agents; and cleaning agents (2.0 (1.1-3.6) and 2.3 (1.4-3.6), respectively), with stronger associations for long-term exposures. These associations were mainly explained by the exacerbation domain of asthma control and no associations were observed between asthmagens and partly controlled asthma.These findings suggest that occupational exposure to asthmagens is associated with uncontrolled adult-onset asthma. Occupational risk factors should be quickly identified to prevent uncontrolled asthma. @ERSpublications Occupational exposure to asthmagens is associated with uncontrolled adult-onset asthma in ECRHS II

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Section: Figurementioning

confidence: 99%

Occupational exposures and uncontrolled adult-onset asthma in the European Community Respiratory Health Survey II

Moual¹,

Carsin²,

Siroux³

et al. 2013

European Respiratory Journal

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“…Asthma is known to affect males more in childhood and females more in adulthood (1)(2)(3). Studies supporting this observation have focused on four epidemiologic aspects of the disease: (1) cross-sectional prevalence (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17), (2) onset (18)(19)(20), (3) remission and relapse (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31), and (4) healthcare use (32)(33)(34)(35)(36)(37)(38)(39)(40).…”

mentioning

confidence: 99%

Natural Progression of Childhood Asthma Symptoms and Strong Influence of Sex and Puberty

Fu¹,

Freishtat

Gordish‐Dressman

et al. 2014

Annals ATS

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Rationale: Asthma prevalence, onset, remission and relapse, and healthcare use have been intensively studied. However, asthma symptom progression through childhood and adolescence has not been well studied, in part due to the challenges in obtaining consistent and robust long-term follow-up data on a large series of subjects with asthma.Objectives: To use the asthma diary symptom data of the Childhood Asthma Management Program placebo group (5 yr, 418 subjects, and total 564,518 records) to establish sex-specific highresolution time courses of the natural progression of asthma symptoms through childhood and adolescence.Methods: We used the asthma diary symptom code as a measure of daily disease severity. Annual records of Tanner stage were used to determine the influence of puberty on severity. A data alignment technique was used to derive 13-year time courses of mean symptoms and mean Tanner stage.Measurements and Main Results: Data analyses showed three age-and sex-related phases of asthma symptom progression: Phase 1 (ages 5 and 6 yr)-greater severity in boys; Phase 2 (ages 7 to 9 yr)-no sex difference in severity; and Phase 3 (age 10-17 yr)-greater severity in girls. The continuous decline of symptoms in both sexes stops abruptly at the onset of puberty. Conclusions:The severity of asthma symptoms varies through childhood and adolescence, and patterns differ by sex. Puberty has a strong influence on symptom progression in both sexes. Progression of symptoms is a distinct aspect of asthma epidemiology.

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“…O ver the last 10 yrs, several questionnairebased studies on the incidence of asthma have been published, showing an incidence of about 1-3 cases per 1,000 person-yrs [1][2][3]. About 15% of all incident cases of asthma among adults are due to exposure in the workplace [4], and it is a well-described fact that many allergens (sensitisers) can induce occupational asthma.…”

mentioning

confidence: 99%

Incidence of asthma among workers exposed to sulphur dioxide and other irritant gases

Andersson

Knutsson²,

Hagberg³

et al. 2006

European Respiratory Journal

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The aim of the present study was to investigate whether repeated peak exposure (gassings) to sulphur dioxide (SO 2 ) and other irritant gases increases the risk of new-onset asthma. A questionnaire was sent to 4,112 sulphite workers, of whom 1,919 completed the questionnaire and 396 completed the short-form questionnaire, which was sent out as a last reminder. A sample of 130 nonrespondents completed a telephone interview using the short-form questionnaire.The incidence of adult-onset, physician-diagnosed asthma during employment duration was analysed in relation to exposure to SO 2 and gassings giving rise to respiratory symptoms. Incidence rates, as well as incidence rate ratios with 95% confidence interval (CI), were calculated. Further Cox regression models were used allowing assessment of hazard ratios (HR) stratified for sex and adjusted for atopy, smoking habits and age.The incidence rate for asthma among sulphite mill workers reporting gassings of SO 2 was 6.2 out of 1,000 person-yrs, compared with 1.9 out of 1,000 person-yrs among subjects unexposed to SO 2 and any gassings (HR (95% CI) 4.0 (2.1-7.7)). Among males reporting gassings to SO 2 , the HR (95% CI) for asthma was 5.8 (2.6-13) compared with unexposed males.In conclusion, repeated peak exposure to sulphur dioxide increased the incidence of asthma during work in sulphite pulp mills, which supports the hypothesis of irritant-induced asthma.

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Incidence and remission of asthma: A retrospective study on the natural history of asthma in Italy

Cited by 179 publications

References 25 publications

Occupational exposures and uncontrolled adult-onset asthma in the European Community Respiratory Health Survey II

Occupational exposures and uncontrolled adult-onset asthma in the European Community Respiratory Health Survey II

Natural Progression of Childhood Asthma Symptoms and Strong Influence of Sex and Puberty

Incidence of asthma among workers exposed to sulphur dioxide and other irritant gases

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