Objective
To examine the 25-year cumulative incidence of macular edema (ME) and its relation to various risk factors.
Design
Population-based study.
Participants
Nine hundred and fifty-five insulin-taking persons living in an 11-county area in southern Wisconsin with type 1 diabetes diagnosed before age 30 years who participated at baseline (1980-1982) and at least one of 4 follow-up (4-, 10-, 14-, and 25-year) examinations (n=891) or died before the first follow-up examination (n=64).
Methods
Stereoscopic color fundus photographs were graded using the modified Airlie House classification and the Early Treatment Diabetic Retinopathy Study retinopathy severity scheme. Competing risk of death was included in statistical models.
Main Outcome Measures
Incidence of ME and clinically significant ME (CSME).
Results
The 25-year cumulative incidence of ME was 29% and for CSME it was 17%. Annualized incidence of ME were 2.3, 2.1, 2.3, and 0.9%, respectively, in the 1st, 2nd, 3rd, and 4th follow-up periods of the study. In univariate analyses, the incidence of ME was associated with more severe diabetic retinopathy, being male, having higher glycosylated hemoglobin, proteinuria, higher systolic and diastolic blood pressure, and having smoked more pack years. Multivariate analyses showed that the incidence of ME was related to higher baseline glycosylated hemoglobin (Hazard Ratio [HR] per 1% 1.17, 95% Confidence Interval [CI] 1.10, 1.25, P<0.001) and higher systolic blood pressure (HR per 10 mmHg 1.15, 95% CI 1.04, 1.26, P=0.004) and marginally to proteinuria (HR 1.43, 95% CI 0.99, 2.08, P=0.06).
Conclusions
These data show that relatively high 25-year cumulative rates of incidence of ME were related to glycemia and blood pressure. The lower risk of incident ME in the last period of the study may reflect recent improvement in care.