Summary:A regularly scheduled physical training program seems to have antithrombotic effects. Moreover, the hemostatic changes occurring in patients with coronary artery disease during acute exercise have not been clearly elucidated. Since stress testing is routinely performed in clinical cardiology, it would be helpful to assess whether patients with coronary artery disease are exposed to acute coronary thrombosis during or soon after sustained physical exercise. This study was designed to evaluate the effect of acute physical exercise (stress test by bicycle ergometer) on blood coagulation in a group of patients with previous myocardial infarction, and to determine whether the antithrombotic therapy commonly administered favorably influences hemostatic equilibrium. Our results suggest that exercise testing is not harmful to patients with previous myocardial infarction in regard to hemostasis and fibrinolysis and that antithrombotic therapy reduces postexercise increase in platelets. platelet aggregability. In spite of these data, studies on the effect of stress test on blood coagulation and fibrinolysis yielded conflicting Particularly, the hemostatic changes in patients with coronary artery disease during acute exercise are not clearly elucidated. Some investigators suggested that the majority of patients with myocardial ischemia show increased platelet activity and decreased fibrinolysis at rest, l 3 whereas others were unable to demonstrate such changes.*.l4Since sustained physical exercise is routinely performed for clinical evaluation in cardiology, it would be helpful to assess whether or not patients with coronary artery disease are exposed to acute coronary thrombosis during or soon after stress testing.This study was designed to evaluate the effect of acute physical exercise on blood coagulation and fibrinolysis in a group of patients with previous myocardial infarction and to determine whether the antithrombotic therapy commonly administered to postinfarction patients favorably influences the hemostatic equilibrium.