Incidence and profile of C3 Glomerulopathy: A single center study

Abstract

C3 glomerulopathy has recently been described as a distinct entity. The underlying mechanism is unregulated activation of the alternate pathway of the complement system. The most common presentation is with an acute nephritic syndrome. The diagnosis is made on immunofluoroscence by the presence of isolated or dominant C3 staining. In this retrospective study, renal biopsy data were collected from 2010 to 2013 patients with C3 glomerulopathy identified and their clinical and biochemical parameters analyzed. Out of 514 biopsies available for analysis, the incidence of C3 glomerulopathy was 1.16% (n = 6). The mean age of the presentation was 26 years and the average estimated glomerular filtration rate was 30.65 ml/min/1.73 m2. The most common histopathological pattern was membranoproliferative glomerulonephritis (n = 4).

C3 glomerulopathy in children: Is there still a place for anti‐cellular immunosuppression?

“…The incidence of C3GP among patients who have undergone renal biopsy is very randomly reported, ranging from 1% 23 to 1.16%, 24 and was 4.6% in our study. Medjeral-Thomas et al 25 conducted a retrospective cohort study in 80 adults and children in the UK and Ireland with C3GP, and estimated an annual incidence of one to two cases per million population.…”

“…The incidence of C3GP among patients who have undergone renal biopsy is very randomly reported, ranging from 1% to 1.16%, and was 4.6% in our study. Medjeral‐Thomas et al .…”

Histopathological Patterns of Renal Biopsies in Children with Various Glomerulopathies in a Tertiary Care Centre

“…Total seven cases (11.67%) with C3 deposition were observed and reported as C3 dominant glomerulonephritis. It comprised 0.7 % of all renal biopsies in a study by Viswanathan et al 29 30 . This discrepancy could be attributed to small sample size.…”

“…Evaluation of such cases requires measurement of individual complement factor levels and screening for mutations of complement regulatory proteins. 30 These tests are currently available in research labs only.…”

Changes in the complement system in membranoproliferative glomerulonephritis

“…Однако последняя не отмечена ни у одного пациента с С3-ГП, причем у 3 из них НС персистировал на протяжении 10 лет, несмотря на неоднократную смену режимов ИСТ, демонстрируя полную резистентность к стандартной ИСТ. Наибольшая выраженность НС отмечалась именно в группе С3-ГП, пациенты которой имели самые высокие уровни СПУ и самые низкие -альбумина, что согласуется с зарубежными данными [19]. Следует отметить, что между группами С3-ГП и ВН различия по СПУ достигали статистической значимости (р 1-3 =0,005).…”