Incidence and preventability of adverse drug events in hospitalized adults

Bates, David W.; Leape, Lucian L.; Petrycki, Stephen

doi:10.1007/bf02600138

Cited by 314 publications

(246 citation statements)

References 17 publications

Supporting

Mentioning

222

Contrasting

Unclassified

Order By: Relevance

“…Studies have shown that age, gender, co morbidity, number of drugs, and length of hospital stay are significant risk factors for development of ADRs [36,[39][40][41][42][43][44]. Our study revealed polypharmacy and multiple disease state as the most prevalent predisposing factors in patients who developed ADRs.…”

Section: Discussionmentioning

confidence: 52%

Spontaneous reporting of adverse drug reactions at a department of Internal Medicine

et al. 2010

View full text Add to dashboard Cite

AbstractThe aim of the present study was to characterize the pattern of adverse drug reactions (ADRs) reported in a university teaching hospital in south-east Serbia. The study was conducted based on ADRs reported during a six-month period to the ADR reporting unit of the university clinical center. Evaluation of data was done for various parameters, such as patient demographics, drug and reaction characteristics, and outcome of reactions. Assessment was also done for causality, severity and predisposing factors. During the 6-month study period, 44 ADRs were reported, with an overall incidence of 0.33%. No significant difference was seen in the overall incidence of ADRs observed in males and females. Incidence of ADRs among elderly (43.2%) and older (25%) adults was significantly higher than in other age groups. Type A reactions (66.7%) accounted for majority of the reports. The most commonly affected organ system was the renal system, (22.7%) with hyperkalemia as the only reported reaction. ACE inhibitors (48.6%) were the drug class most commonly involved, where fosinopril (25.7%) was the individual drug most frequently reported. Additional treatment was pursued for management of ADRs in majority (52.3%) of the reports. In 52.3 % of the reports, the patient had recovered from the reaction by the time of evaluation. Upon causality assessment, the majority of the reports were rated as probable (43.2%). Mild and moderate reactions accounted for 43.2% and 54.6%, respectively. In 36.3% of the reports, the reaction was considered to be preventable. The most common predisposing factors were polypharmacy and multiple disease state. The pattern of ADRs reported in our hospital is comparable to the results of studies conducted in hospital set up elsewhere. Our evaluations revealed opportunities for intervention to ensure safer drug use.

show abstract

Section: Discussionmentioning

confidence: 52%

Spontaneous reporting of adverse drug reactions at a department of Internal Medicine

et al. 2010

View full text Add to dashboard Cite

show abstract

“…The first group, instruments using only a definition of preventability, included three instruments (8,18,19) (Table II, Figure 2). All three instruments shared the same preventability categories and no specific criteria for determining the type of a preventability category, apart from the definition for preventability, were mentioned.…”

Section: Resultsmentioning

confidence: 99%

Methods for Assessing the Preventability of Adverse Drug Events

et al. 2012

View full text Add to dashboard Cite

“…Studies have shown age, gender, co morbidity, number of drugs, and length of stay in the hospital as significant risk factors for development of ADRs. [27][28][29] Our study revealed polypharmacy, multiple disease state and unnecessary use of antibacterial agents as the most prevalent predisposing factors in patients who developed ADRs. Since many of the reports were from medicine department where in usually the patients have multiple co morbidities and hence polypharmacy contributed to the high percentage of reports with these factors as predisposing ones in our study.…”

Section: -25mentioning

confidence: 95%

Adverse Drug Reaction Monitoring and Reporting at H.S.K Hospital and Research Center-Bagalkot

Harikrishna¹,

Prasannakumar²,

Hemanthkumar³

et al. 2016

IJOPP

View full text Add to dashboard Cite

Introduction: Adverse drug reactions (ADRs) Reporting is provides safety and Improves strength of Drug adverse reaction to the Drug. Such ADR reporting programs encourage surveillance for ADRs, promote the reporting of ADRs and stimulate the education of health professionals regarding potential ADRs. Objective: ADR monitoring is an important part of post marketing surveillance which helps in generating data on safety of medications. Main Aim to ADRs Monitoring is to the Promoting rational use of drugs, Safe use of Medicine, Improving patient care, improving public health. Methods and Material: This was a prospective, observational, voluntary reporting study. Study was conducted in H.S.K Hospital and Research centre, Navanagar, Bagalkot, Karnataka. Samples was collected from Skinand VD, General Medicine, Pediatric Department and in all age groups. We are taken support of WHO Scale, Naranjo scale, Hartwig scale, CDSCO Form to collect the data. Result: In our study observed 77 ADRs in overall 59 patients of with ADRs reported from 180 patients was reported from both inpatients and outpatients, in this outpatients were less compared to inpatient. Highest ADRs are reported in (28.4%) skin rashes, General Medicine (69.7%) in different organs like Hematology, Cardiology, and Central nerves system, Hepatic, Renal, Endocrine, Respiratory and Gastrointestinal. In those study Antibiotic (20.8%) were causes high ADRs in those moderate level (75.3%) ADRs high than sever (10.4) in those as per WHO scale casual assessment probable (46.8%) ADRs were high. As per age group Incidence of ADRs among 0-15 age is 1.7% is less than 16-30 age group is 32.2% and is significantly higher than other age groups. In these studies we got type-A reactions as 26.08% is less than type-B reactions as 73.92%. Conclusion: The present evaluation has revealed opportunities for interventions especially for the avoidable ADRs which will help in promoting safer drug use, information to the healthcare professionals. Improve the quality of patient care and educate to increase awareness.

show abstract

Incidence and preventability of adverse drug events in hospitalized adults

Cited by 314 publications

References 17 publications

Spontaneous reporting of adverse drug reactions at a department of Internal Medicine

Spontaneous reporting of adverse drug reactions at a department of Internal Medicine

Methods for Assessing the Preventability of Adverse Drug Events

Adverse Drug Reaction Monitoring and Reporting at H.S.K Hospital and Research Center-Bagalkot

Contact Info

Product

Resources

About