Incidence and prevalence of Type 1 (insulin-dependent) diabetes mellitus in Icelandic children 1970?1989

Helgason, Tómas; Daníelsen, Ragnar; Þórsson, Árni V.

doi:10.1007/bf00399936

Cited by 34 publications

(20 citation statements)

References 25 publications

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“…Between 1970 and 1976 the incidence in Denmark was about one-half that in Sweden [14,22,23], but by the end of the 1980s Denmark had reached the incidence rates of Sweden and Norway and had joined the high-risk Nordic countries. The lowest rate among the Nordic countries was in Iceland [24], the northern-most island nation in Europe. Within-country variation in incidence rates has been reported in the Nordic countries, in Norway, Sweden and Finland in the 1970s [23,26,27] and in the 1980s in the British Isles [28][29][30] and in Italy where the within-country variation was the largest in Europe [14,17,31].…”

Section: Geographic Variation Of Type 1 Diabetes Morbiditymentioning

confidence: 94%

A review of the recent epidemiological data on the worldwide incidence of Type 1 (insulin-dependent) diabetes mellitus

Karvonen¹,

Tuomilehto²,

et al. 1993

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Nearly 70 registries from more than 40 countries have collected and published incidence data of childhood Type 1 (insulin-dependent) diabetes mellitus up to the end of the 1980s. The majority of incidence data comes from regions of high incidence i.e. from Europe and North America. All these published data facilitate the descriptive comparison of incidence and variation of the occurrence of Type 1 diabetes roughly throughout the northern hemisphere. The aim of this paper is to review and compare the most recent epidemiology data on the incidence of Type 1 diabetes among children under the age of 15 years. A clear difference in incidence appeared between northern and southern hemisphere with no countries below the equator having an incidence greater than 15.0 per 100,000. In contrast above the equator the disease is common. Between continents the variation in incidence showed that the lowest incidences were found in Asia, followed by Oceania (Australia and New Zealand), South and North America, and the highest rates were in Europe. The incidence varied from 0.6 per 100,000 in Korea and Mexico to 35.3 per 100,000 in Finland showing prominent worldwide variation in incidence of Type 1 diabetes. The largest intracontinental variation in incidence appeared in Europe, varying from the highest in Finland to the lowest (4.6 per 100,000) in northern Greece. The highest incidence in the world was in northern Europe, but within the continent scale there were some striking exceptions from the overall level of incidence.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Geographic Variation Of Type 1 Diabetes Morbiditymentioning

confidence: 94%

A review of the recent epidemiological data on the worldwide incidence of Type 1 (insulin-dependent) diabetes mellitus

Karvonen¹,

Tuomilehto²,

et al. 1993

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“…Over 85 % of known diabetic patients have attended the adult and paediatric diabetic clinics at Landspitali, University Hospital, Reykjavik [10,11]. The registers of these services were in- …”

Section: Methodsmentioning

confidence: 99%

MODY in Iceland is associated with mutations in HNF -1? and a novel mutation in NeuroD1

Kristinsson

Thorolfsdottir²,

Talseth

et al. 2001

Diabetologia

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Maturity-onset diabetes of the young (MODY) is a subgroup of diabetes which is inherited and which could account for 2±5 % of Type II diabetic patients [1]. Information on rare monogenic forms of diabetes could shed light on the development of the more common multigenic varieties of diabetes mellitus.Clinical and metabolic profiles of families with MODY can be diverse [2,3]. Currently, mutations in five genes are known to be associated with MODY and several families with MODY have not been linked to any of the known MODY genes [3±9]. Mutations in genes encoding transcription factors important for normal development and function of pancreatic beta cells have recently become a focus of attention in genetic studies of diabetes mellitus.The aim of this study was to investigate the clinical features and genetic causes of MODY in Iceland. Subjects and methodsOver 85 % of known diabetic patients have attended the adult and paediatric diabetic clinics at Landspitali, University Hospital, Reykjavik [10,11]. The registers of these services were in-

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“…Large differences in incidence have been reported in Caucasoid populations living in relatively close proximity and among those who are genetically similar. For example, the incidence in the Nordic countries (Finland, Sweden, and Norway) is 2-4 times higher than that in Estonia (3,4,13,14) and 2-3 times higher than that in Iceland (15). Large interethnic differences in the incidence rates between Jewish and Arab populations have been reported in Israel (16).…”

mentioning

confidence: 98%

Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group.

Karvonen¹,

Viik-Kajander²,

Moltchanova³

et al. 2000

Diabetes Care

863

437

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OBJECTIVE: To investigate and monitor the patterns in incidence of childhood type 1 diabetes worldwide. RESEARCH DESIGN AND METHODS: The incidence of type 1 diabetes (per 100,000 per year) from 1990 to 1994 was determined in children < or =14 years of age from 100 centers in 50 countries. A total of 19,164 cases were diagnosed in study populations totaling 75.1 million children. The annual incidence rates were calculated per 100,000 population. RESULTS: The overall age-adjusted incidence of type 1 diabetes varied from 0.1/100,000 per year in China and Venezuela to 36.8/100,000 per year in Sardinia and 36.5/100,000 per year in Finland. This represents a >350-fold variation in the incidence among the 100 populations worldwide. The global pattern of variation in incidence was evaluated by arbitrarily grouping the populations with a very low (<1/100,000 per year), a low (1-4.99/100,000 per year), an intermediate (5-9.99/100,000 per year), a high (10-19.99/100,000 per year), and a very high (> or =20/100,000 per year) incidence. Of the European populations, 18 of 39 had an intermediate incidence, and the remainder had a high or very high incidence. A very high incidence (> or =20/ 100,000 per year) was found in Sardinia, Finland, Sweden, Norway Portugal, the U.K., Canada, and New Zealand. The lowest incidence (<1/100,000 per year) was found in the populations from China and South America. In most populations, the incidence increased with age and was the highest among children 10-14 years of age. CONCLUSIONS: The range of global variation in the incidence of childhood type 1 diabetes is even larger than previously described. The earlier reported polar-equatorial gradient in the incidence does not seem to be as strong as previously assumed, but the variation seems to follow ethnic and racial distribution in the world population.

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Incidence and prevalence of Type 1 (insulin-dependent) diabetes mellitus in Icelandic children 1970?1989

Cited by 34 publications

References 25 publications

A review of the recent epidemiological data on the worldwide incidence of Type 1 (insulin-dependent) diabetes mellitus

A review of the recent epidemiological data on the worldwide incidence of Type 1 (insulin-dependent) diabetes mellitus

MODY in Iceland is associated with mutations in HNF -1? and a novel mutation in NeuroD1

Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group.

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