Incidence and prevalence of neuromyelitis optica spectrum disorders in Slovakia

Szilasiová, Jarmila; Gazda, Jakub; Cimprichová, Andrea; Cvengrošová, Anna; Donáth, Vladimír; Fedičová, Miriam; Gurčík, Ladislav; Hančinová, Viera; Jurčaga, František; Kahancová, Edita; Kantorová, Ema; Karlík, Martin; Klímová, Eleonóra; Kováčová, Slavomíra; Krastev, Georgi; Megová, Andrea; Michalík, Jozef; Mikula, Pavol; Snopeková, Ľubica; Števková, Zuzana

doi:10.1080/01616412.2021.1952741

Cited by 3 publications

(1 citation statement)

References 25 publications

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“…For countries closest to Poland, the prevalence was: Austria, 0.7 per 100,000; Catalonia, 0.89 per 100,000; Northwest England, 0.72 per 100,000; and Southeast Wales, 1.96 per 100,000 [ 43 ]. For countries bordering Poland, the most recent epidemiological study performed in Slovakia estimate the crude incidence rate was 0.88 per 1,000,000 person-years and the age-adjusted point prevalence rate was 1.42 per 100,000 persons [ 44 ]. For the central-east Europe country of Hungary, the numbers published in 2020, the authors reported the crude prevalence was 1.91 per 100,000 persons and the age-standardized prevalence was 1.87 per 100,000 persons [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

NMOSD—Diagnostic Dilemmas Leading towards Final Diagnosis

et al. 2022

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(1) Background: The emergence of white matter lesions in the central nervous system (CNS) can lead to diagnostic dilemmas. They are a common radiological symptom and their patterns may overlap CNS or systemic diseases and provoke underdiagnosis or misdiagnosis. The aim of the study was to assess factors influencing the underdiagnosis of neuromyelitis optica spectrum disorder (NMOSD) as well as to estimate NMOSD epidemiology in Lubelskie voivodeship, Poland. (2) Methods: This retrospective study included 1112 patients, who were made a tentative or an established diagnosis of acute or subacute onset of neurological deficits. The evaluation was based on medical history, neurological examination, laboratory and radiographic results and fulfilment of diagnosis criteria. (3) Results: Up to 1.62 percent of patients diagnosed with white matter lesions and up to 2.2% of the patients previously diagnosed with MS may suffer from NMOSD. The duration of delayed diagnosis is longer for males, despite the earlier age of onset. Seropositive cases for antibodies against aquaporin-4 have worse prognosis for degree of disability. (4) Conclusions: Underdiagnosis or misdiagnosis in NMOSD still remains a problem in clinical practice and has important implications for patients. The incorrect diagnosis is caused by atypical presentation or NMOSD-mimics; however, covariates such as gender, onset and diagnosis age may also have an influence.

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Section: Discussionmentioning

confidence: 99%

NMOSD—Diagnostic Dilemmas Leading towards Final Diagnosis

et al. 2022

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Clinical and demographic characteristics of patients with NMOSD: a longitudinal retrospective analysis of a Slovak cohort of 63 patients

Szilasiová,

Gazda,

Mikula

et al. 2023

Neurol Sci

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Incidence and Prevalence of Neuromyelitis Optica Spectrum Disorders in the Background of International Consensus Diagnostic Criteria – A Systematic Review

2022

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Introduction of international consensus criteria (2015 IPND criteria) for neuromyelitis optica spectrum disorders (NMOSDs) has improved diagnostic accuracy for aquaporin 4 (AQP4)-IgG-associated and seronegative NMOSDs. This study aimed to review relevant publications related to the incidence and prevalence of NMOSDs and provide an updated review of the global epidemiology of NMOSDs in the light of new diagnostic criteria. A comprehensive literature search was performed from January 2015 to June 2021 by using appropriate keywords in PubMed, Scopus, and Web of Science. Relevant papers that fulfilled inclusion criteria were shortlisted and reviewed. Twenty-one papers were selected for this review. Incidence of NMOSDs was 0.04–0.25/100,000 in predominantly white and 0.34–1.31/100,000 in nonwhite populations. Prevalence was 0.70–1.91/100,000 in white and 0.86–4.52/100,000 in nonwhite populations. The 2015 IPND criteria significantly improved the incidence and prevalence rates for NMOSDs when compared to the Wingerchuk 2006 criteria. Incidence of MOG-IgG-associated NMOSDs was 0.12–0.13/100,000, with prevalence in children 0.03–1.4/100,000 and in adults 0.65–2/100,000. In this systematic review, studies that used uniform diagnostic criteria and confirmed cases after testing for AQP4-IgG were included. The prevalence of NMOSDs was estimated to be <5/100,000 globally. A clear bias was seen in favor of nonwhite and indigenous populations. This review highlights the need for prospective population-based epidemiological studies and the importance of surveys in nonwhite populations around the globe.

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Incidence and prevalence of neuromyelitis optica spectrum disorders in Slovakia

Cited by 3 publications

References 25 publications

NMOSD—Diagnostic Dilemmas Leading towards Final Diagnosis

NMOSD—Diagnostic Dilemmas Leading towards Final Diagnosis

Clinical and demographic characteristics of patients with NMOSD: a longitudinal retrospective analysis of a Slovak cohort of 63 patients

Incidence and Prevalence of Neuromyelitis Optica Spectrum Disorders in the Background of International Consensus Diagnostic Criteria – A Systematic Review

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