Incidence and Prevalence of Microscopic Colitis Between 2001 and 2016: A Danish Nationwide Cohort Study

Weimers, Petra; Ankersen, Dorit Vedel; Lophaven, Søren Nymand; Bonderup, Ole K.; Münch, Andreas; Løkkegaard, Ellen; Burisch, Johan; Munkholm, Pia

doi:10.1093/ecco-jcc/jjaa108

Cited by 32 publications

(28 citation statements)

References 30 publications

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“…1 The incidence of microscopic colitis has been rising during the last decades, levelling out with incidence rates reaching 25 per 100 000 person per year. 1,2 The condition is primarily diagnosed in the elderly and the majority of patients are women. [1][2][3] Although the aetiology and pathogenesis of microscopic colitis…”

Section: Introductionmentioning

confidence: 99%

Autoimmune diseases in microscopic colitis: A Danish nationwide case–control study

Wildt

Munck

Winther-Jensen

et al. 2021

Aliment Pharmacol Ther

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Background:The association between autoimmune diseases and microscopic colitis remains uncertain. Aims:To describe the association between autoimmune diseases and microscopic colitis by using a matched case-control design based on nationwide registry data. Methods:All adult Danish patients with a diagnosis of microscopic colitis from 2001 to 2018 were identified from nationwide registries. Odds of autoimmune diseases were compared between cases with microscopic colitis and sex-and age-matched controls from the background population in a 1:10 ratio and evaluated by logistic regression calculating odds ratios (OR) with 95% confidence intervals (CI) adjusted for comorbidity. Analyses were stratified according to sex, age and the subtypes of lymphocytic and collagenous colitis. Results:We identified 15 597 cases with microscopic colitis and matched to 155 910 controls. In total, 3491 (22%) of patients with microscopic colitis had concomitant autoimmune disease compared to 16 521 (11%) of controls (OR, 2.46; 95% CI, 2.36-2.56). Adjusting for comorbidities reduced the OR to 2.09 (95% CI, 2.01-2.19).Analyses showed increased ORs with 16 different autoimmune diseases, particularly of gastrointestinal and endocrine origin, and connective tissue disorders. The highest ORs were for coeliac disease (OR = 10.15; 95% CI, 8.20-12.6), Crohn's disease (OR = 2.47; 95% CI, 2.10-2.91) and ulcerative colitis (OR = 6.73; 95% CI, 6.20-7.30). In stratified analyses younger age at diagnosis and collagenous colitis were associated with higher odds. Conclusion:Using nationwide registry data, microscopic colitis was associated with a wide range of autoimmune diseases, especially of gastrointestinal origin. The results suggest an autoimmune predisposition to microscopic colitis.

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Section: Introductionmentioning

confidence: 99%

Autoimmune diseases in microscopic colitis: A Danish nationwide case–control study

Wildt

Munck

Winther-Jensen

et al. 2021

Aliment Pharmacol Ther

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“…3 The incidence of microscopic colitis has been increasing and is now thought to be comparable to or exceed inflammatory bowel disease. [4][5][6][7][8] Some of the increased incidence is due to greater recognition of the disease. 9 The aetiology of microscopic colitis is unknown.…”

Section: Introductionmentioning

confidence: 99%

Medication use and microscopic colitis

Sandler

Keku

Woosley

et al. 2021

Aliment Pharmacol Ther

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Background: Microscopic colitis is an increasingly common cause of watery diarrhoea. Several classes of medications have been associated with microscopic colitis in prior studies. Aims:To determine the association between the use of previously implicated medications and microscopic colitis.Methods: This was a case-control study of patients referred for elective, outpatient colonoscopy for diarrhoea. Patients were excluded for inflammatory bowel disease, C difficile, or other infectious diarrhoea. Colon biopsies were reviewed by the study pathologist and patients were classified as microscopic colitis cases or non-microscopic colitis controls. Results:The study population included 110 microscopic colitis cases and 252 controls. The cases were older, better educated and more likely to be female. Cases reported a greater number of loose, watery, or liquid stools, nocturnal stools, more urgency and weight loss compared to controls. There was no association with proton pump inhibitors (PPIs), adjusted OR (aOR) 0.66, 95% CI 0.38-1.13 or nonsteroidal anti-inflammatory drugs, aOR 0.68, 95% CI 0.40-1.17. Cholecystectomy was less common in cases, aOR 0.33, 95% CI 0.17-0.64, but microscopic colitis cases had more frequent bowel movements following cholecystectomy. Conclusion:Compared to similar patients with diarrhoea, cases with microscopic colitis were not more likely to have taken previously implicated medications. They had more diarrhoea following cholecystectomy, suggesting that bile may play a role in symptoms or aetiology. We conclude that the appropriate choice of controls is crucial to understanding risk factors for microscopic colitis.

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“…Эпидемиологические данные за последние 15 лет свидетельствуют о неуклонном повышении показателей распространенности и заболеваемости МК, особенно в странах Северной Америки и Европы [7][8][9]. Согласно популяционным данным, приведенным в последних европейских клинических рекомендациях UEG/EMCG (2021 г.…”

Section: эпидемиология и факторы рискаunclassified

Microscopic colitis from the standpoint of modern gastroenterology

Андреев¹,

Dentistry²,

Маев³

et al. 2021

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Microscopic colitis is a chronic inflammatory bowel disease of unknown etiology, characterized by chronic watery diarrhea, the absence of macroscopic signs of colon lesions in the presence of specific pathological changes. This review article presents the current view on microscopic colitis, including its definition, epidemiology, risk factors, clinical manifestations, diagnostic criteria and treatment tactics according to the last European clinical guidelines UEG/EMCG (2021).

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Incidence and Prevalence of Microscopic Colitis Between 2001 and 2016: A Danish Nationwide Cohort Study

Abstract: Abstract Background and Aims Epidemiological studies suggest an increasing global incidence of microscopic colitis, including collagenous colitis and lymphocytic colitis. We aimed to investigate the incidence and prevalence of microscopic colitis in Denmark. Methods Show more

Cited by 32 publications

References 30 publications

Autoimmune diseases in microscopic colitis: A Danish nationwide case–control study

Autoimmune diseases in microscopic colitis: A Danish nationwide case–control study

Medication use and microscopic colitis

Microscopic colitis from the standpoint of modern gastroenterology

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