Incidence and prevalence of depressive, anxiety, and insomnia symptoms among adult liver transplant recipients: A systematic review and meta-analysis

Biyyala, Deepika; Joseph, Rini; Varadharajan, Natarajan; Krishnamoorthy, Yuvaraj; Menon, Vikas

doi:10.1016/j.genhosppsych.2022.12.003

Cited by 3 publications

(3 citation statements)

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“…Quality of included studies was assessed using the Joanna Briggs Institute (JBI) critical appraisal checklist for cohort studies 18 . If at least 70% of answers were scored as yes (or not applicable), the study was coded as having a low risk of bias; if the range was 50%–69%, studies were at moderate risk; and studies scoring <50% were at high risk; this approach has been used previously 19 . Two authors (NV, SB) independently performed quality appraisals.…”

Section: Methodsmentioning

confidence: 99%

“…18 If at least 70% of answers were scored as yes (or not applicable), the study was coded as having a low risk of bias; if the range was 50%-69%, studies were at moderate risk; and studies scoring <50% were at high risk; this approach has been used previously. 19 Two authors (NV, SB) independently performed quality appraisals. Disagreements, if any, were resolved through discussion and consensus with a third author (VM); if necessary, a senior author (CA) was also involved in resolving conflicts.…”

Section: Study Appraisalmentioning

confidence: 99%

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Gestational exposure to benzodiazepines or z‐hypnotics and neurodevelopmental disorders in offspring: Systematic review and meta‐analysis

Andrade,

Varadharajan,

Bascarane

et al. 2024

Acta Psychiatr Scand

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IntroductionBenzodiazepine (BDZP) and/or z‐hypnotic dispensing during pregnancy has increased globally, as have rates of autism spectrum disorder (ASD) and attention‐deficit hyperactivity disorder (ADHD). This systematic review and meta‐analysis aimed to estimate the association between gestational exposure to BDZP and/or z‐hypnotics and diagnosis of ASD or ADHD in offspring.MethodsWe searched MEDLINE, EMBASE, and SCOPUS from inception till December 2023 for relevant English‐language articles. Outcomes of interest were risk of ASD and ADHD, two independent primary outcomes, in children exposed anytime during pregnancy to BDZP and/or z‐hypnotics versus those unexposed. Secondary outcomes were trimester‐wise analyses. Using a random effects model, we pooled the overall and trimester‐wise hazard ratios (HRs), with 95% confidence intervals (CIs), separately for risk of ASD and ADHD.ResultsWe found six eligible retrospective cohort studies and no case–control studies. There was no increased risk of ASD associated with anytime gestational BDZP and/or z‐hypnotic exposure (primary outcome, HR, 1.10; 95% CI, 0.81–1.50; 4 studies; n = 3,783,417; 80,270 exposed, 3,703,147 unexposed) nor after first trimester exposure (HR, 1.15; 95% CI, 0.83–1.58; 3 studies; n = 1,539,335; 70,737 exposed, 1,468,598 unexposed) or later trimester exposures. A very small but significantly increased risk of ADHD was noted with anytime gestational exposure to these drugs (primary outcome, HR, 1.07; 95% CI, 1.03–1.12; 4 studies; n = 2,000,777; 78,912 exposed, 1,921,865 unexposed) and also with (only) second trimester exposure (HR, 1.07; 95% CI, 1.03–1.12; 3 studies; n = 1,539,281; 33,355 exposed, 1,505,926 unexposed). Findings were consistent in sensitivity analyses.ConclusionGestational exposure to benzodiazepines or z‐hypnotics was not associated with an increased risk of ASD and with only a marginally increased risk of ADHD in offspring. Given the likelihood of confounding by indication and by unmeasured variables in the original studies, our findings should reassure women who need these medications for severe anxiety or insomnia during pregnancy.

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Section: Methodsmentioning

confidence: 99%

Section: Study Appraisalmentioning

confidence: 99%

Gestational exposure to benzodiazepines or z‐hypnotics and neurodevelopmental disorders in offspring: Systematic review and meta‐analysis

Andrade,

Varadharajan,

Bascarane

et al. 2024

Acta Psychiatr Scand

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“…Psychological morbidity among transplant recipients may negatively impact post-transplantation outcomes. Biyyala et al 60 conducted a systematic review and meta-analysis of observational studies to assess the incidence and prevalence of depression, anxiety, and insomnia symptoms during the post-transplant period among adult LT recipients. Sixty-five studies (pooled n = 12,183) provided data for meta-analysis.…”

Section: Liver Transplantationmentioning

confidence: 99%

Abdominal Organ Transplantation: Noteworthy Literature in 2023

Katayama,

Maffucci,

Domanski

et al. 2024

Semin Cardiothorac Vasc Anesth

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This review highlights noteworthy literature published in 2023 and pertinent to anesthesiologists and critical care physicians caring for patients undergoing abdominal organ transplantation. We feature 9 studies from 593 peer-reviewed papers on pancreatic transplantation, 3 from 194 on intestinal transplantation, and 28 from over 4513 on kidney transplantation. The liver transplantation section includes a special focus on 20 studies from 5666 clinical trial publications. We explore a broad range of topics, including donor management, perioperative recipient management, and innovative pharmacologic and mechanical interventions tested for the improvement of patient and graft outcomes and survival.

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The prevalence of depression, anxiety, and sleep disturbances in patients with neuromyelitis optica spectrum disorders (NMOSD): A systematic review and meta-analysis

Liu,

Zhang,

Zhong

et al. 2023

Multiple Sclerosis and Related Disorders

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Incidence and prevalence of depressive, anxiety, and insomnia symptoms among adult liver transplant recipients: A systematic review and meta-analysis

Cited by 3 publications

References 70 publications

Gestational exposure to benzodiazepines or z‐hypnotics and neurodevelopmental disorders in offspring: Systematic review and meta‐analysis

Gestational exposure to benzodiazepines or z‐hypnotics and neurodevelopmental disorders in offspring: Systematic review and meta‐analysis

Abdominal Organ Transplantation: Noteworthy Literature in 2023

The prevalence of depression, anxiety, and sleep disturbances in patients with neuromyelitis optica spectrum disorders (NMOSD): A systematic review and meta-analysis

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