Incidence and Predictors of Recurrence and Mortality Following First Venous Thromboembolism Among the Saudi Population: Single-Center Cohort Study

Al-Eidan, Fahad A.; AlManea, Reem K; AlMoneef, Alyah T; Shalash, Nada A; AlRajhi, Norah A; AlMousa, Sarah F; Raizah, Abdulrahman Al; Abuelgasim, Khadega A.

doi:10.2147/ijgm.s359893

Cited by 7 publications

(5 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A review of the literature has found a significantly increased risk for DVT, and/or PE in subjects with obesity, and a reduced risk for underweight subjects, as well as an increased risk of recurrent embolic events once anticoagulation treatment has been stopped/withdrawn [21]. Our observations are in agreement with those of AlEidan, et al, who found that among patients with recurrent VTE, active cancer, and obesity were independent predictors of mortality [22]. Obesity is associated with several factors like raised intraabdominal pressure, immobility, chronic impairment of fibrinolysis, high levels of fibrinogen, factor VIII levels, von Willebrand factor, and a low-grade inflammatory state [23].…”

Section: Discussionsupporting

confidence: 92%

Clinical Features and Predictors of Mortality in Patients With Acute Pulmonary Embolism: A Retrospective Study From Southern Saudi Arabia

Abuelhassan,

Alsalem,

Alshafa

et al. 2024

Cureus

View full text Add to dashboard Cite

Background and methodology: We aimed to investigate the clinical characteristics, outcomes, and mortality predictors in patients with acute pulmonary embolism (PE). Adult patients who were admitted to the Armed Forces Hospital Southern Region, Khamis Mushait, a large tertiary hospital in Southern Saudi Arabia, with the diagnosis of acute PE were retrospectively examined for the predictors of one-year mortality.Results: The overall in-hospital mortality was 15.6% among 212 patients. In univariate analysis, only age was significantly associated with increased early mortality, whereas age, obesity, presence of active malignancy, hypertension, use of thrombolytics, and Simplified Pulmonary Embolism Severity Index (sPESI) were significantly associated with increased late mortality. By use of binary logistic regression, the presence of obesity (HR 6.010, 95%CI 0.048-16.853, p=0.030), active malignancy (HR 3.040, 95%CI 1.147-8.059, p=0.025), and the use of thrombolytics (HR 8.074, p<0.001), were independently significant factors for late (overall) mortality, respectively.Conclusions: Among Saudi Arabian patients in the Southern Region, our data show that age is an independent factor for increased early and late mortality. The presence of obesity, active malignancy, and the use of thrombolytics, were independently significant factors for increased late (one-year) mortality. These factors should be taken into account for risk stratification and decisions on tailored management of patients with PE. Further prospective multicenter studies are needed.

show abstract

Section: Discussionsupporting

confidence: 92%

Clinical Features and Predictors of Mortality in Patients With Acute Pulmonary Embolism: A Retrospective Study From Southern Saudi Arabia

Abuelhassan,

Alsalem,

Alshafa

et al. 2024

Cureus

View full text Add to dashboard Cite

show abstract

“…Regarding venous thromboembolism (VTE) events, a single-center cohort study among the Saudi population reported a cumulative incidence of 0.17% (1.7 per 1000 patients) over 3 years, with an overall incidence of 158 per 1000 person-years for recurrent VTE. 39 These findings are higher than those in the current study, reported an event rate of 0.76% (1.02 per 1000 person-years). Contrarily, a Swedish register-based cohort study found a VTE incidence of 0.71% among RA patients, compared to 0.36% in the matched general population.…”

Section: Discussioncontrasting

confidence: 73%

Incidence Rate of Cardiovascular Events in Rheumatoid Arthritis: An Observational Cohort Study in Saudi Arabia

AlGhalawin,

Alomar,

Al Bassam

et al. 2024

JMDH

View full text Add to dashboard Cite

Purpose Rheumatoid arthritis (RA) doubles the morbidity of cardiovascular disease (CVD) and leads to a 50% increase in mortality compared to the general population. This study aims to estimate the CVD incidence among RA patients in Saudi Arabia (SA), vital for assessing CVD burdens within this group. Patients and Methods This retrospective study took place at two centers in the Eastern Province of SA, including all adult RA patients who visited the rheumatology clinic from 2016 to 2021 and were prescribed disease-modifying antirheumatic drugs (DMARDs). CVD incidence was determined by the diagnosis of ischemic heart disease (IHD), stroke/transient ischemic attack (TIA), venous thromboembolism (VTE), heart failure (HF), and arrhythmia post-RA diagnosis. Additional data collected included demographics, CVD risk factors, comorbidities, RA-related factors, and medication usage. Results The study comprised 651 patients, 80.5% of whom were females with an average age of 51. The overall CVD incidence was 11.2 per 1000 person-years, with males experiencing five times more incidents than females. The prevalence of CVD risk factors included 18.7% with hypertension, 7.8% with hyperlipidemia, 18.9% with diabetes, and 42.9% with obesity. Significant predictors of CVD were male gender and RA duration, with adjusted odds ratios (aOR) of 3.17 (95% CI 1.10 to 9.14, P=0.033) and 64.81 (95% CI 3.68 to 1140.6, P=0.004), respectively. Conclusion This unique study from SA examined the CVD incidence in RA patients, identifying long disease duration and male gender as significant predictors. Effective reduction of CVD risk in RA patients requires aggressive management of modifiable risk factors and regular risk assessments.

show abstract

“…However, the nationwide prevalence of PE in Saudi Arabia remains unknown. A single tertiary care center study suggested that the annual incidence rate of the first venous thromboembolism was 1.7 per 1,000 patients [3]. Other hospital-based studies reported a range of 5-33.8 [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic approach and use of CTPA in patients with suspected pulmonary embolism in an emergency department in Saudi Arabia

et al. 2023

View full text Add to dashboard Cite

Background: In patients with suspected pulmonary embolism (PE), the literature suggests the overuse of computerized tomography pulmonary angiography (CTPA) and underuse of clinical decision rules before imaging request. This study determined the potential for avoidable CTPA using the modified Wells score (mWS) and D-dimer assay in patients with suspected PE. Methods:This hospital-based retrospective study analyzed the clinical data of 661 consecutive patients with suspected PE who underwent CTPA in the emergency department of a tertiary hospital for the use of a clinical prediction rule (mWS) and D-dimer assay. The score was calculated retrospectively from the available data in the files of patients who did not have a documented clinical prediction rule. Overuse (avoidable) CTPA was defined as D-dimer negativity and PE unlikely for this study. Results:Of 661 patients' data examined, clinical prediction rules were documented in 15 (2.3%). In total, 422 patients (63.8%) had required information on modified Wells criteria and D-dimer assays and were included for further analysis. PE on CTPA was present in 22 (5.21%) of PE unlikely (mWS ≤4) and 1 (0.24%) of D-dimer negative patients. Thirty patients (7.11%) met the avoidable CTPA (DD negative+PE unlikely) criteria, and it was significantly associated with dyspnea. The value of sensitivity of avoidable CTPA was 100%, whereas the positive predictive value was 90.3%. Conclusion:Underutilization of clinical prediction rules before prescribing CTPA is common in emergency departments. Therefore, a mandatory policy should be implemented regarding the evaluation of avoidable CTPA imaging to reduce CTPA overuse.

show abstract

Incidence and Predictors of Recurrence and Mortality Following First Venous Thromboembolism Among the Saudi Population: Single-Center Cohort Study

Cited by 7 publications

References 43 publications

Clinical Features and Predictors of Mortality in Patients With Acute Pulmonary Embolism: A Retrospective Study From Southern Saudi Arabia

Clinical Features and Predictors of Mortality in Patients With Acute Pulmonary Embolism: A Retrospective Study From Southern Saudi Arabia

Incidence Rate of Cardiovascular Events in Rheumatoid Arthritis: An Observational Cohort Study in Saudi Arabia

Diagnostic approach and use of CTPA in patients with suspected pulmonary embolism in an emergency department in Saudi Arabia

Contact Info

Product

Resources

About