Incidence and predictors of idiopathic pulmonary fibrosis complicating <scp>Type 2</scp> diabetes: the <scp>Fremantle Diabetes Study Phase</scp> I

Navaratnam, Vidya; Davis, Timothy; Hubbard, Richard; Davis, Wendy A.

doi:10.1111/imj.15191

Cited by 7 publications

(7 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It could be related to the phenomenon of paradoxical obesity. In this way, in people with diabetes, overweight has been associated with a lower risk for in-hospital mortality [45]. It is also possible that patients with diabetes are admitted to the hospital more frequently than patients without diabetes with the same clinical severity.…”

Section: Discussionmentioning

confidence: 99%

Sex Differences in the Incidence and Outcomes of Patients Hospitalized by Idiopathic Pulmonary Fibrosis (IPF) in Spain from 2016 to 2019

Ballesteros

López-Herránz

López‐de‐Andrés

et al. 2021

JCM

View full text Add to dashboard Cite

(1) Background: To assess sex differences in the incidence, characteristics, procedures and outcomes of patients admitted with idiopathic pulmonary fibrosis (IPF); and to analyze variables associated with in-hospital mortality (IHM). (2) Methods: We analyzed data collected by the Spanish National Hospital Discharge Database, 2016–2019. (3) Results: We identified 13,278 hospital discharges (66.4% men) of IPF (primary diagnosis 32.33%; secondary diagnosis: 67.67%). Regardless of the diagnosis position, IPF incidence was higher among men than women, increasing with age. Men had 2.74 times higher IPF incidence than women. Comorbidity was higher for men in either primary or secondary diagnosis. After matching, men had higher prevalence of pulmonary embolism and pneumonia, and women of congestive heart failure, dementia, rheumatoid disease and pulmonary hypertension. Invasive ventilation, bronchoscopy and lung transplantation were received more often by men than women. IHM was higher among men with IPF as primary diagnosis than among women and increased with age in both sexes and among those who suffered cancer, pneumonia or required mechanical ventilation. (4) Conclusions: Incidence of IPF was higher among men than women, as well as comorbidity and use of bronchoscopy, ventilation and lung transplantation. IHM was worse among men than women with IPF as primary diagnosis, increasing with age, cancer, pneumonia or mechanical ventilation use.

show abstract

Section: Discussionmentioning

confidence: 99%

Sex Differences in the Incidence and Outcomes of Patients Hospitalized by Idiopathic Pulmonary Fibrosis (IPF) in Spain from 2016 to 2019

Ballesteros

López-Herránz

López‐de‐Andrés

et al. 2021

JCM

View full text Add to dashboard Cite

show abstract

“…In the present meta-analysis, it was revealed that the prevalence of diabetes was increased markedly in IPF cases compared with controls, which suggests that DM and IPF might be positively associated. However, we noticed that a latest study [ 31 ] came to the opposite conclusion. Since all of the included studies are retrospective case–control studies, which are easily affected by recall bias and additionally, the interpretation of the outcome is in the limitation of the significant heterogeneity, which could not be satisfactorily explained, we believe that our conclusion still need further evidence.…”

Section: Discussionmentioning

confidence: 71%

Idiopathic pulmonary fibrosis and diabetes mellitus: a meta-analysis and systematic review

et al. 2021

View full text Add to dashboard Cite

Background Idiopathic pulmonary fibrosis (IPF) is a chronic diffuse interstitial lung disease, of which the etiology has been poorly understood. Several studies have focused on the relationship between IPF and diabetes mellitus (DM) in the past years but have failed to reach a consensus. This meta-analysis aimed to examine the association between diabetes to IPF. Methods We accumulated studies investigating the association between DM and IPF from databases including Medline, Cochrane Library, Embase, Web of Science, and China National Knowledge Infrastructure. RevMan 5.3 and the Newcastle–Ottawa Scale (NOS) were utilized to analyze the data and assess the quality of the included studies. The value of odds ratio (OR) with 95% confidence interval (CI) was used as the measure to estimate the risk of DM in IPF. Heterogeneity was assessed by I2 statistics. We also performed subgroup analysis, meta-regression, and Egger’s test for bias analysis. Results Nine case–control studies with 5096 IPF patients and 19,095 control subjects were included in the present meta-analysis, which indicated a positive correlation between DM and IPF (OR 1.65, 95% CI 1.30–2.10; P < 0.0001). Meta-regression and subgroup analysis negated the influence of covariates like cigarette smoking, age and gender, but the heterogeneity existed and could not be fully explained. Conclusion IPF and DM may be associated, but the causal relationship remains indeterminate till now. Further rigorously designed studies are required to confirm the present findings and investigate the possible mechanisms behind the effect of DM on IPF.

show abstract

“…This may be attributed to either the occurrence of cardiovascular mortality prior to the development of IPF in patients with diabetes or the prolonged survival of patients with coexisting diabetes and IPF [ 23 ]. Another population-based case-control study reported that the incidence of IPF was higher in individuals with T2D compared to non-T2D population (incidence rate ratio = 1.40, 95% CI = 0.76–2.44, P = 0.22), although this difference did not reach statistical significance [ 24 ]. Notably, the level of glycemic control was not mentioned among participants with T2D in the original study.…”

Section: Discussionmentioning

confidence: 99%

Diabetes mellitus and idiopathic pulmonary fibrosis: a Mendelian randomization study

Kang,

Ren,

Cong

et al. 2024

BMC Pulm Med

View full text Add to dashboard Cite

Background The question as to whether or not diabetes mellitus increases the risk of idiopathic pulmonary fibrosis (IPF) remains controversial. This study aimed to investigate the causal association between type 1 diabetes (T1D), type 2 diabetes (T2D), and IPF using Mendelian randomization (MR) analysis. Methods We used two-sample univariate and multivariate MR (MVMR) analyses to investigate the causal relationship between T1D or T2D and IPF. We obtained genome-wide association study (GWAS) data for T1D and T2D from the European Bioinformatics Institute, comprising 29,652 T1D samples and 101,101 T1D single nucleotide polymorphisms (SNPs) and 655,666 T2D samples and 5,030,727 T2D SNPs. We also used IPF GWAS data from the FinnGen Biobank comprising 198,014 IPF samples and 16,380,413 IPF SNPs. All cases and controls in these datasets were derived exclusively from European populations. In the univariate MR analysis, we employed inverse variance-weighted (IVW), weighted median (WM), and MR-Egger regression methods. For the MVMR analysis, we used the multivariate IVW method primarily, and supplemented it with multivariate MR-Egger and multivariate MR- least absolute shrinkage and selection operator methods. Heterogeneity tests were conducted using the MR-IVW and MR-Egger regression methods, whereas pleiotropic effects were assessed using the MR-Egger intercept. The results of MR and sensitivity analyses were visualized using forest, scatter, leave-one-out, and funnel plots. Results Univariate MR revealed a significant causal relationship between T1D and IPF (OR = 1.118, 95% CI = 1.021–1.225, P = 0.016); however, no significant causal relationship was found between T2D and IPF (OR = 0.911, 95% CI = 0.796–1.043, P = 0.178). MVMR analysis further confirmed a causal association between T1D and IPF (OR = 1.133, 95% CI = 1.011–1.270, P = 0.032), but no causal relationship between T2D and IPF (OR = 1.009, 95% CI = 0.790–1.288, P = 0.950). Sensitivity analysis results validated the stability and reliability of our findings. Conclusion Univariate and multivariate analyses demonstrated a causal relationship between T1D and IPF, whereas no evidence was found to support a causal relationship between T2D and IPF. Therefore, in clinical practice, patients with T1D should undergo lung imaging for early detection of IPF.

show abstract

Incidence and predictors of idiopathic pulmonary fibrosis complicating Type 2 diabetes: the Fremantle Diabetes Study Phase I

Cited by 7 publications

References 16 publications

Sex Differences in the Incidence and Outcomes of Patients Hospitalized by Idiopathic Pulmonary Fibrosis (IPF) in Spain from 2016 to 2019

Sex Differences in the Incidence and Outcomes of Patients Hospitalized by Idiopathic Pulmonary Fibrosis (IPF) in Spain from 2016 to 2019

Idiopathic pulmonary fibrosis and diabetes mellitus: a meta-analysis and systematic review

Diabetes mellitus and idiopathic pulmonary fibrosis: a Mendelian randomization study

Contact Info

Product

Resources

About