Incidence and predictors of cardiac arrhythmias in patients with COVID-19 induced ARDS

Niehues, Philipp; Wegner, Felix K.; Wolfes, Julian; Willy, Kevin; Ellermann, Christian; Vollenberg, Richard; Reinecke, Holger; Rosenow, Felix; Lepper, Johannes; Sackarnd, Jan; Eckardt, Lars

doi:10.1016/j.jjcc.2022.04.010

Cited by 8 publications

(3 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Multiple clinical studies have shown that patients with COVID-19 are prone to developing new AF and that new-onset AF predicts a poor prognosis ( 22 – 25 ). Pre-existing AF also exacerbates symptoms as well as the risk of death in patients with COVID-19 ( 26 , 27 ).…”

Section: Discussionmentioning

confidence: 99%

Comprehensive bioinformatics analysis reveals common potential mechanisms, progression markers, and immune cells of coronary virus disease 2019 and atrial fibrillation

Yang

Zhao

2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

ObjectivesAtrial fibrillation (AF) is the most common arrhythmia in coronary virus disease 2019 (COVID-19) patients, especially in severe patients. A history of AF can exacerbate COVID-19 symptoms. COVID-19 Patients with new-onset AF have prolonged hospital stays and increased death risk. However, the mechanisms and targets of the interaction between COVID-19 and AF have not been elucidated.Materials and methodsWe used a series of bioinformatics analyses to understand biological pathways, protein-protein interaction (PPI) networks, gene regulatory networks (GRNs), and protein-chemical interactions between COVID-19 and AF and constructed an AF-related gene signature to assess COVID-19 severity and prognosis.ResultsWe found folate and one-carbon metabolism, calcium regulation, and TFG-β signaling pathway as potential mechanisms linking COVID-19 and AF, which may be involved in alterations in neutrophil metabolism, inflammation, and endothelial cell function. We identified hug genes and found that NF-κb, hsa-miR-1-3p, hsa-miR-124-3p, valproic acid, and quercetin may be key regulatory molecules. We constructed a 3-gene signature consisting of ARG1, GIMAP7, and RFX2 models for the assessment of COVID-19 severity and prognosis, and found that they are associated with neutrophils, T cells, and hematopoietic stem cells, respectively.ConclusionOur study reveals a dysregulation of metabolism, inflammation, and immunity between COVID-19 and AF, and identified several therapeutic targets and progression markers. We hope that the results will reveal important insights into the complex interactions between COVID-19 and AF that will drive novel drug development and help in severity assessment.

show abstract

Section: Discussionmentioning

confidence: 99%

Comprehensive bioinformatics analysis reveals common potential mechanisms, progression markers, and immune cells of coronary virus disease 2019 and atrial fibrillation

Yang

Zhao

2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“…• AF is a common occurrence following infection with SARS-CoV-2 (COVID-19) [257][258][259][260][261][262][263][264][265][266][267]. • The Odds Ratio (OR) for AF 365 days after COVID-19 compared to a well-established control group was 1.83 in a large study [268].…”

Section: Examples In Which We Know That Infection Can Lead To Atrial ...mentioning

confidence: 99%

Fibrinaloid Microclots and Atrial Fibrillation

Kell,

Lip,

Pretorius

2024

Biomedicines

View full text Add to dashboard Cite

Atrial fibrillation (AF) is a comorbidity of a variety of other chronic, inflammatory diseases for which fibrinaloid microclots are a known accompaniment (and in some cases, a cause, with a mechanistic basis). Clots are, of course, a well-known consequence of atrial fibrillation. We here ask the question whether the fibrinaloid microclots seen in plasma or serum may in fact also be a cause of (or contributor to) the development of AF. We consider known ‘risk factors’ for AF, and in particular, exogenous stimuli such as infection and air pollution by particulates, both of which are known to cause AF. The external accompaniments of both bacterial (lipopolysaccharide and lipoteichoic acids) and viral (SARS-CoV-2 spike protein) infections are known to stimulate fibrinaloid microclots when added in vitro, and fibrinaloid microclots, as with other amyloid proteins, can be cytotoxic, both by inducing hypoxia/reperfusion and by other means. Strokes and thromboembolisms are also common consequences of AF. Consequently, taking a systems approach, we review the considerable evidence in detail, which leads us to suggest that it is likely that microclots may well have an aetiological role in the development of AF. This has significant mechanistic and therapeutic implications.

show abstract

“…Bradyarrhythmias have been reported in hospitalized patients with coronavirus disease 2019 (COVID-19). Niehues et al 1 described an incidence of 6% severe bradycardia during ICU stay in COVID-19 patients with moderate to severe acute respiratory distress syndrome (ARDS). Severe bradycardia requiring acute medical intervention are, however, less common.…”

Section: Introductionmentioning

confidence: 99%

Single-center experience of temporary-permanent pacemaker use in COVID-19 patients supported with veno-venous ECMO: A case series

et al. 2022

View full text Add to dashboard Cite

Introduction: In the first year of the COVID-19 pandemic, nine out of 129 patients (7%) developed life-threatening bradycardia episodes ultimately requiring a TPPM, whilst being supported with VV-ECMO for severe COVID-19 ARDS in our tertiary cardio-pulmonary failure center. Analysis: All subjects had asystole due to sinus node dysfunction and experienced at least one episode involving cardiopulmonary resuscitation. Most bradycardic events were seen in the context of vagal hypersensitivity. Mean time from general ICU admission to TPPM insertion was 20.6 ± 8.9 days. One patient developed a large chest wall hematoma weeks after TPPM implantation, no other TPPM-related issues were observed. No patient required a long-term pacing system. Six-months survival rate was high (89%). Conclusion: These findings suggested that transient life-threatening sinus node disease is not uncommon in ECMO-dependent COVID-19 ARDS patients. TPPM with an active fixation lead is sometimes needed to facilitate ongoing ICU care, however, long-term permanent pacing was not required.

show abstract

Incidence and predictors of cardiac arrhythmias in patients with COVID-19 induced ARDS

Cited by 8 publications

References 18 publications

Comprehensive bioinformatics analysis reveals common potential mechanisms, progression markers, and immune cells of coronary virus disease 2019 and atrial fibrillation

Comprehensive bioinformatics analysis reveals common potential mechanisms, progression markers, and immune cells of coronary virus disease 2019 and atrial fibrillation

Fibrinaloid Microclots and Atrial Fibrillation

Single-center experience of temporary-permanent pacemaker use in COVID-19 patients supported with veno-venous ECMO: A case series

Contact Info

Product

Resources

About