Incidence and predictors of acute symptomatic seizures after stroke

Abstract

The incidence of acute symptomatic seizures is the highest reported in patients with first stroke with prospective follow-up. Hemorrhagic stroke and cortical lesion were independent predictors of acute symptomatic seizures. Hyperlipidemia was a protective factor for hemorrhagic stroke.

The CAVE Score for Predicting Late Seizures After Intracerebral Hemorrhage

“…Cumulative risk of LS was 7.1% at 1 year after ICH and 11.8% at 5 years. This is in line with earlier reports [3][4][5]19,20 although comparisons between studies are difficult because of different patient populations, seizure criteria, and follow-up…”

Incidence and Associations of Poststroke Epilepsy

“…Furthermore, our findings support the previously observed relationship of cortical insults (such as TACI) and subsequent epilepsy. 6 The temporal lobe is the most epileptogenic region of the brain and the most frequent subject of epilepsy surgery, 21 followed by the frontal lobe, both with anterior circulation supply. Large events involving the middle and superior temporal gyri are particularly associated with the development of late seizures, 22 and cortical tumors of any type are most associated with epilepsy.…”

“…1 The incidence and associations of poststroke epilepsy (PSE) are not well-established; many previous studies have investigated seizure episodes, rather than epilepsy diagnoses, with uncertainty frequently arising from varying definitions of seizure timing, selective recruitment, and short follow-up. [2][3][4][5] Hemorrhagic strokes, cortical lesions, and large lesions are most consistently associated with poststroke seizures, 6 defined as early or late, based on timing and differing pathophysiology.…”

“…1 The incidence and associations of poststroke epilepsy (PSE) are not well-established; many previous studies have investigated seizure episodes, rather than epilepsy diagnoses, with uncertainty frequently arising from varying definitions of seizure timing, selective recruitment, and short follow-up. [2][3][4][5] Hemorrhagic strokes, cortical lesions, and large lesions are most consistently associated with poststroke seizures, 6 defined as early or late, based on timing and differing pathophysiology. [7][8][9][10] A wide range (2% to 67%) of patients has been reported for the risk of early or late seizures after ischemic stroke, 11 whereas intracerebral and subarachnoid hemorrhages have been associated with a range of between 8% and 15% over varying durations of follow-up.…”

“…[7][8][9][10] A wide range (2% to 67%) of patients has been reported for the risk of early or late seizures after ischemic stroke, 11 whereas intracerebral and subarachnoid hemorrhages have been associated with a range of between 8% and 15% over varying durations of follow-up. 6 There is insufficient evidence to reliably predict those who will have development of PSE and would benefit from prophylactic antiepileptic treatment. Of those with a single seizure, approximately half were observed to have progression to epilepsy in a well-designed study with a maximum follow-up of 6.5 years.…”