Incidence and predictability of amiodarone-induced thyrotoxicosis and hypothyroidism

Hofmann, Andrea; Nawara, C.; Ofluoglu, Sedat; Holzmannhofer, J.; Strohmer, Bernhard; Pirich, Christian

doi:10.1007/s00508-008-1017-2

Cited by 19 publications

(25 citation statements)

References 27 publications

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“…3,4 The proportions of patients with amiodarone-induced dysfunction of the thyroid have been estimated at 0.6%-20.8% (thyrotoxicosis) and 3.3%-25.8% (hypothyroidism). [5][6][7][8] However, the incidence of thyroid dysfunction has not been estimated previously in a large-scale, population-based cohort.…”

mentioning

confidence: 99%

Amiodarone-induced thyroid dysfunction: brand-name versus generic formulations

Tsadok

Jackevicius²,

Rahme³

et al. 2011

Canadian Medical Association Journal

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confidence: 99%

Amiodarone-induced thyroid dysfunction: brand-name versus generic formulations

Tsadok

Jackevicius²,

Rahme³

et al. 2011

Canadian Medical Association Journal

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“…100% of those with high score were confi rmed, thus, for this group of patients the Newcastle index has been reliable, but in case of medium scores (11)(12)(13)(14)(15)(16)(17)(18)(19), the Newcastle index has proved to be irrelevant in the present study (22% had confi rmed hyperthyroidism). A smaller incidence of amiodarone induced hyperthyroidism of only 3% has been noted in a study conducted by Hoff man et al in 2008 [12]. While the male:female ratio in the aforementioned study was 3:1, in our study it was 1:3.…”

Section: Discussionmentioning

confidence: 46%

“…Out of the 8 patients with confi rmed thyroid dysfunction, 4 had high Newcastle score and 4 had a medium Newcastle score (11)(12)(13)(14)(15)(16)(17)(18)(19).…”

Section: Resultsmentioning

confidence: 99%

The Incidence and Risk of Inducing Hyperthyroidism Following Amiodarone Treatment

Farcaș

Keresztesi

Silivastru

et al. 2013

Acta Medica Marisiensis

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Introduction: Amiodarone, a frequently used antiarrhythmic drug in cardiology, is very effi cient in the treatment of ventricular and supraventricular tachiarrithmyas. The iodine content of amiodarone is 39%. Its chemical structure is similar to tyrosine. It is estimated that 1-23% of patients treated with amiodarone can develop hyperthyroidism. The purpose of this study is to assess and monitor the incidence of hyperthyroidism induced by amiodarone in patients admitted for various types of cardiac dysrhythmias, considering that most of the patients included in the study came from an endemic goitre area. Material and method: One-hundred patients chosen systematically (62 men, 38 women) from 560 patients treated with amiodarone in the January 1 st , 2009 -December 31, 2009 period were assessed (clinically, laboratory fi ndings and imaging studies); their mean age was 64 years (range 50-70 years). In order to identify and diagnose hyperthyroidism, a questionnaire (Newcastle index) was used, also urinary iodine dosage, hormonal dosages (T3, T4, TSH) and thyroid imaging (ultrasound, radioactive iodine uptake test) were used. Results: The incidence of hyperthyroidism induced by amiodarone in this study was 8%. Hyperthyroidism was more frequent in women (6 women vs. 2 men). Conclusions: Thyroid hormonal levels have to be determined and a clinical or thyroid ultrasound examination should be made prior to initiating a treatment with amiodarone. At the end of the study, 8 patients, most of them female, were diagnosed with hyperthyroidism.

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“…Amiodarone induced thyrotoxicosis (AIT) has an incidence of 2-23%, with a higher frequency in iodine-deficient areas (2-13% in the U.S, 9.6% in Italy) [6,7,8].…”

Section: Introductionmentioning

confidence: 99%

The Characteristics of Amiodarone-induced Thyrotoxicosis in a Moderate Iodine Deficit Area

Ancuța-Elena

Capraru

Ionela

2013

Acta Medica Marisiensis

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Introduction: Amiodarone (AMI), a class III anti-arrhythmic drug, is associated with a number of side effects, including thyroid dysfunction (both hypo-and hyperthyroidism), which is due to amiodarone's high iodine content and its direct toxic effect on the thyroid. Objective: To evaluate the incidence of Amiodarone induced thyrotoxicosis (AIT) (type, rate of occurrence) and to identify the risk factors involved in its occurrence. Material and method:We examined patients treated with amiodarone, between January 2002 and December 2011, who presented to our Department of Endocrinology Târgu Mures for thyroid dysfunctions. Results: The retrospective study included 87 patients with thyroid dysfunctions; 58 (66.7%) patients had AIT and 29 (33.3%) had Amiodarone induced hypothyroidism (AIH). In the AIT group: 35 were women (60.3%), 23 were men (39.7%); the average age was 61.60 ± 12.39 years. Risk factors identifi ed for the AIT group were male gender (RR = OR = 3.8; Chi-squer = 5.7, p = 0.004) and pre-existing thyroid abnormalities (RR = 2.5, Chi-square = 4.1, p = 0.005). The thyroid dysfunction occurrence was heterogeneous (0.2-183 months). The patients with previous thyroid abnormalities developed earlier thyroid dysfunction compared to those with an apparently normal thyroid gland (22.25 ± 4.14 months versus 32.09 ± 7.69 months, p = 0.02, T test). Conclusion: In the context of the specifi c iodine geoclimatic intake and the area of origin, amiodarone -induced thyroid dysfunction spectrum is dominated by thyrotoxicosis. Screening and monitoring of thyroid function for patiens under chronic amiodarone treatment is necessary.

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Incidence and predictability of amiodarone-induced thyrotoxicosis and hypothyroidism

Cited by 19 publications

References 27 publications

Amiodarone-induced thyroid dysfunction: brand-name versus generic formulations

Amiodarone-induced thyroid dysfunction: brand-name versus generic formulations

The Incidence and Risk of Inducing Hyperthyroidism Following Amiodarone Treatment

The Characteristics of Amiodarone-induced Thyrotoxicosis in a Moderate Iodine Deficit Area

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