Incidence and pathophysiologic mechanisms of stroke in the COVID-19 pandemic: the dilemma

Salim, Mohamed; El-Mohsen, Seham Abd; El-Hassan, Osama Abo; Abdelhaffez, Azza; El‐Aziz, Nashwa Abd

doi:10.1186/s43168-020-00033-y

Cited by 3 publications

(3 citation statements)

References 13 publications

(22 reference statements)

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“…With this modified DT, our results had revealed a high prevalence (60%) of distress among COVID-19 patients. Being a novel global illness, no one is immune [12][13][14], several aspects of this disease are still vague in the eye of the general population, affecting many body organs and systems [15,16], and still has no definitive therapy, COVID-19 represents a real stressful condition and explains the high prevalence of distress among our cohort.…”

Section: Characteristicmentioning

confidence: 99%

Utility of a modified distress thermometer in screening COVID-19 patients for psychological distress: A prospective Egyptian study

et al. 2021

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Background: The National Comprehensive Cancer Network (NCCN) has adopted the distress thermometer (DT) as one of the best-known distress-screening instruments. We have adopted a modified version of the NCCN distress thermometer.We questioned if this modified DT (m-DT) could be utilized for measuring the prevalence of psychological distress among COVID-19 patients.Methods: The prospective study included 2 phases; modification of the original DT and its associated problem list (PL), and evaluation of this m-DT in measuring the prevalence of psychological distress among COVID-19 patients. Egyptian adult subjects with suspected or confirmed cases of COVID-19 at 2 University Hospitals were enrolled. Binary logistic regression tests were carried out to explore the association between the m-DT cut-off scores of 4 and the clinical variables.Results: One hundred sixty-nine (60.4%) patients experienced significant distress (m-DT cut off score ≥4). Logistic regression showed that occupation, presence of special habits, length of quarantine time, worry, cough, shortness of breath, and fever, were independent factors associated with significant distress in COVID-19 patients.Conclusion: With the modified distress thermometer (m-DT), 60% of Egyptian COVID-19 patients experienced significant distress. This distress was significantly related to age, marital status, occupation, presence or absence of special habits, and length of the quarantine time. With m-DT, the current study had identified worry, being a health-care worker, shortness of breath, fever, length of quarantine time, presence of special habits, and cough as independent factors associated with significant distress in COVID-19 patients. Further studies are warranted.

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Section: Characteristicmentioning

confidence: 99%

Utility of a modified distress thermometer in screening COVID-19 patients for psychological distress: A prospective Egyptian study

et al. 2021

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“…Specifically, it is not yet known whether these adverse outcomes are attributable to the direct impact of the virus on cerebral vessels or if they are due to the overall effect of the virus on the patient's bodily functions. 23 …”

Section: Discussionmentioning

confidence: 99%

COVID‐19 Infection Is Associated With Poor Outcomes in Patients With Intracerebral Hemorrhage

Renedo,

Leasure,

Young

et al. 2024

JAHA

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Background Patients with ischemic stroke and concomitant COVID‐19 infection have worse outcomes than those without this infection, but the impact of COVID‐19 on hemorrhagic stroke remains unclear. We aimed to assess if COVID‐19 worsens outcomes in intracerebral hemorrhage (ICH). Methods and Results We conducted an observational study of ICH outcomes using Get With The Guidelines Stroke data. We compared patients with ICH who were COVID‐19 positive and negative during the pandemic (March 2020–February 2021) and prepandemic (March 2019–February 2020). Main outcomes were poor functional outcome (defined as a modified Rankin scale score of 4 to 6 at discharge), mortality, and discharge to a skilled nursing facility or hospice. The first stage included 60 091 patients with ICH who were COVID‐19 negative and 1326 COVID‐19 positive. In multivariable analyses, patients with ICH with versus without COVID‐19 infection had 68% higher odds of poor outcome (odds ratio [OR], 1.68 [95% CI, 1.41–2.01]), 51% higher odds of mortality (OR, 1.51 [95% CI, 1.33–1.71]), and 66% higher odds of being discharged to a skilled nursing facility/hospice (OR, 1.66 [95% CI, 1.43–1.93]). The second stage included 62 743 prepandemic and 64 681 intrapandemic cases with ICH. In multivariable analyses, patients with ICH admitted during versus before the COVID‐19 pandemic had 10% higher odds of poor outcomes (OR, 1.10 [95% CI, 1.07–1.14]), 5% higher mortality (OR, 1.05 [95% CI, 1.02–1.08]), and no significant difference in the risk of being discharged to a skilled nursing facility/hospice (OR, 0.93 [95% CI, 0.90–0.95]). Conclusions The pathophysiology of the COVID‐19 infection and changes in health care delivery during the pandemic played a role in worsening outcomes in the patient population with ICH.

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“…11 Hiperkoagulasi pada penelitian ini menggunakan acuan nilai D-Dimer sebesar > 1,0 µl/mL. 21 14 SNH pada penderita COVID-19 diduga terjadi akibat adanya proses hiperkoagulasi yang terjadi akibat inflamasi sistemik, kerusakan endotel vaskular, hingga disfungsi jantung. Trombosis yang menjadi emboli di pembuluh darah otak juga turut berperan dalam terjadinya SNH melalui mekanisme fibrinolitik shutdown dan antibody fosfolipid.…”

Section: Hasilunclassified

Korelasi Faktor Resiko Stroke Terhadap Penderita Corona Virus Disease-2019 Di Rumah Sakit RST Dompet Dhuafa Bogor

Putra sanjaya

2024

eum

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Latar belakang: Stroke menduduki tempat kedua sebagai penyakit tidak menular (PTM) yang menyebabkan 11,6% dari total kematian di dunia pada tahun 2019? kasus stroke semenjak adanya pandemi COVID-19 (Corona Virus Disease-2019) mengalami peningkatan akibat kekhawatiran terinfeksi COVID-19 saat mengakses fasilitas kesehatan, baik itu kasus stroke non-hemoragik (SNH) dan stroke hemoragik (SH). Tujuan penelitian ini adalah untuk mengetahui korelasi factor resiko stroke terhadap penderita CORONA VIRUS DISEASE-2019. Metode: penelitian ini menggunakan metode cross sectional dari data populasi pasien COVID-19 dengan diagnosis juga SNH dan SH periode Januari 2020 – Maret 2022. Hasil penelitian: hasil analisis uji fisher menunjukan secara statistik bahwa bahwa terdapat hubungan yang bermakna antara dislipidemia dan c-reaktif protein dengan kejadian stroke pada penderita COVID-19 yang sedang dirawat di bangsal dengan nilai p value = 0.04 (p <0,05). Kesimpulan: Infeksi COVID-19 dapat menyebabkan terjadinya stroke, baik itu SNH atau SH. Timbulnya stroke ini dipicu adanya hiperkoagulasi dan hiperinflamasi yang terjadi selama infeksi COVID-19 yang banyak menyerang kelompok lanjut usia dan kriteria COVID-19 derajat berat. Kata kunci: Covid-19, stroke ischemik, stroke hemoragik

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Incidence and pathophysiologic mechanisms of stroke in the COVID-19 pandemic: the dilemma

Cited by 3 publications

References 13 publications

Utility of a modified distress thermometer in screening COVID-19 patients for psychological distress: A prospective Egyptian study

Utility of a modified distress thermometer in screening COVID-19 patients for psychological distress: A prospective Egyptian study

COVID‐19 Infection Is Associated With Poor Outcomes in Patients With Intracerebral Hemorrhage

Korelasi Faktor Resiko Stroke Terhadap Penderita Corona Virus Disease-2019 Di Rumah Sakit RST Dompet Dhuafa Bogor

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