Incidence and outcomes of women with Hodgkin’s lymphoma in pregnancy: a population-based study on 7.9 million births

Abstract

The incidence of HL in pregnancy appears to be higher than previously reported with no temporal trend over an 8-year period. Although there is a greater risk of preterm birth and maternal postpartum blood transfusion and VTE, overall maternal and neonatal major morbidity and mortality does not appear to be increased.

Frequency of Pregnancy-Associated Cancer: A Systematic Review of Population-Based Studies

“…No trend in incidence was found for cervical cancer [7,13]. An increase was found for Hodgkin lymphoma [16] while no trend was found for non-Hodgkin lymphoma [15]. The two studies on melanoma gave inconsistent results [8,25].…”

“…The majority of the studies were based on national registries. Five studies relied on a database covering 20% of country community hospital inpatient stays [12,13,[15][16][17], and one used data from two multicentric studies [14]. Among the registry-based studies, ten used data from a linkage between a hospital discharge registry, a maternal/birth registry and a cancer registry [2][3][4][6][7][8][9][10]25,26].…”

“…One study did not report the procedure of PAC identification [21]. Among the 20 studies which firstly selected the baseline population, five (out of the seven using only a hospital discharge registry), restricted information to the time of delivery, thus obtaining cancer cases present at time of delivery [12,13,[15][16][17]. [18,21,25].…”

“…For specific types of cancer, estimates were more variable ( Table 2). With reference to the distribution of PAC diagnosis prior or after birth, five studies did not consider the postpregnancy period in the identification of PAC [12,13,[15][16][17]. One study did not report the distribution during pregnancy and postpregnancy [3].…”

Maternal risk: assessment and management

“…In their articles, Haslinger et al [1] and Hasegawa et al [2] discuss risk factors associated with anal sphincter tears and rates of uterine rupture, outcomes that are possible throughout the spectrum of obstetric care. El-Messidi et al [3] report on pregnancy outcomes in patients with Hodgkin's lymphoma, a unique subset of patients whose risk profile the authors aim to describe. The breadth of subject areas in this special edition emphasizes the heterogeneity of risk in contemporary practice and the need for well-developed systems that accurately identify and manage risk within healthcare systems.…”