Incidence and Outcome of Multiple Intracranial Aneurysms in a Defined Population

Abstract

Background and Purpose-Proportions of patients with single and multiple aneurysms among patients suffering from subarachnoid hemorrhage (SAH) are not well established. We evaluated these proportions and the differences in outcome between SAH patients with a single aneurysm and those with multiple aneurysms in a defined population. Methods- Between 1989Between and 1998Between , 2037 to 89 years) with ruptured intracranial aneurysm were treated in 11 hospitals in Nagasaki Prefecture. Multiple aneurysms were found in 361 of these patients. Age-and sex-specific incidences of ruptured aneurysm per 100 000 people were calculated. Results-For both single and multiple aneurysms, the incidences were significantly higher in women than in men 60 to 69 and 70 to 79 years of age. In every age category except 80 to 89 years, the frequency of multiple aneurysms was higher in women than in men. The overall frequency of multiple aneurysms was 20.2% in women, which was significantly higher than the 12.4% in men (PϽ0.0001). In patients 70 to 89 years of age, outcome was significantly worse (in terms of surgical complications) in patients with multiple aneurysms (12.1%) than in patients with a single aneurysm (6.0%). Conclusions-Among all patients with SAH, women Ն50 years of age outnumber other age and sex categories. Female sex itself is also associated with an increased rate of multiple aneurysms among SAH patients. Among the elderly Ն70 years of age, prognosis is less favorable for SAH patients with multiple aneurysms than for those with a single aneurysm.

Treatment of Multiple Intracranial Aneurysms with 1-Stage Coiling

“…[2][3][4][5] Coiling as a treatment for multiple intracranial aneurysms has not been well studied. To our knowledge, only 2 small case series of 1-stage coiling for multiple intracranial aneurysms have been reported in the literature.…”

“…Multiple intracranial aneurysms are frequent, with a reported incidence of 19%-34% of patients who present with SAH. [2][3][4][5] Determining treatment strategy and methods for multiple aneurysms is often complicated. Coiling is currently accepted as a standard treatment for ruptured or unruptured intracranial aneurysms and has been increasingly used, regardless of the location of the intracranial aneurysm.…”

Flow–area relationship in internal carotid and vertebral arteries

“…Cerebral aneurysm rupture is a major cause of hemorrhagic stroke and has high mortality and morbidity rates (Tomasello et al, 1998;Winn et al, 2002;Linn et al, 1996;Kaminogo et al, 2003). The initiation, growth and rupture of cerebral aneurysms are complex multi-factorial processes that are not well understood.…”

Morphometric Features of Ruptured and Unruptured Aneurysms in Surgically Treated Patients with Multiple Intracranial Aneurysms

“…Multiple intracranial aneurysms are diagnosed in 15% to 35% of the patients after aneurysmal SAH [6]. The morbidity and mortality associated with aneurysmal SAH remain high despite advances in D DAVID PUBLISHING Surgically Treated Patients with Multiple Intracranial Aneurysms 2 microneurosurgery, interventional neuroradiology, neuroanaesthesia and critical care.…”