Incidence and outcome of lupus nephritis in French Polynesia

Delarche, Antoine; Lumbroso, Catherine; Fournier, A; Delaval, Ronan; Pourrat, Jacques; Testevuide, Pascale; Leou, Sylvie; Cordonnier, C.; Chauveau, Dominique; Faguer, Stanislas

doi:10.5414/cn109194

Cited by 5 publications

(5 citation statements)

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“…However, we and others have reported the high incidence of rare genetic kidney diseases or autoimmune diseases in this area. 6 , 7 For example, because of founder effect, recurrent variations in COL4A5 and FAN1 respectively explain the high incidence of X-linked Alport syndrome and recessively inherited karyomegaly in French Polynesia. 6 , 8 In addition, we also reported the high incidence of systemic lupus erythematosus in this geographic area.…”

Section: Introductionmentioning

confidence: 99%

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Epidemiology of End-Stage Kidney Disease in French Polynesia: A Plea for Standardized Diagnosis Workflow in Young Adults of First Nations People

Gueguen,

Boyle,

Chune

et al. 2024

Kidney International Reports

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Section: Introductionmentioning

confidence: 99%

“… 6 , 8 In addition, we also reported the high incidence of systemic lupus erythematosus in this geographic area. 7 The epidemiology of CKD may be more complex, especially in young adult patients, and therefore requires refinement using the most recent clinical workflow to improve nephrology-focused public health policies.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of End-Stage Kidney Disease in French Polynesia: A Plea for Standardized Diagnosis Workflow in Young Adults of First Nations People

Gueguen,

Boyle,

Chune

et al. 2024

Kidney International Reports

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“…The cumulative incidence of LN is relatively high in Asians (55%) and Africans (51%) with SLE. The outcome of patients with an early diagnosed LN was significantly improved in recent years [ 2 ] , and thus early diagnosis and treatment of LN can greatly improve the prognosis of patients with SLE [ 3 ] . However, there is a lack of high sensitivity and specificity markers for early diagnosis of LN.…”

Section: Introductionmentioning

confidence: 99%

Peripheral CD4<sup>+</sup>CD8<sup>+</sup> double positive T cells: A potential marker to evaluate renal impairment susceptibility during systemic lupus erythematosus

Chang¹,

Na²,

Liu³

et al. 2023

J Biomed Res

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Lupus nephritis (LN) has a high incidence in systemic lupus erythematosus (SLE) patients, but there is a lack of sensitive predictive markers. The purpose of the study was to investigate the association between the CD4 + CD8 + double positive T (DPT) lymphocytes and LN. The study included patients with SLE without renal impairment (SLE-NRI), LN, nephritic syndrome (NS), or nephritis. Peripheral blood lymphocyte subsets were analyzed by flow cytometry. Biochemical measurements were performed with peripheral blood in accordance with the recommendations proposed by the National Center for Clinical Laboratories. The proportions of DPT cells in the LN group were significantly higher than that in the SLE-NRI group ( t =4.012, P <0.001), NS group ( t =3.240, P =0.001), and nephritis group ( t =2.57, P =0.011). In the LN group, the risk of renal impairment increased significantly in a DPT cells proportion-dependent manner. The risk of LN was 5.136 times (95% confidence interval, 2.115–12.473) higher in cases with a high proportion of DPT cells than those whose proportion of DPT cells within the normal range. These findings indicated that the proportion of DPT cells could be a potential marker to evaluate LN susceptibility, and the interference of NS and nephritis could be effectively excluded when assessing the risk of renal impairment during SLE with DPT cell proportion.

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“…The LN cumulative incidence is relatively high in Asians (55%) and African lineages (51%) with SLE. The outcome of patients with newly diagnosed LN was signi cantly better in recent years [2]. Especially early diagnosis and treatment of LN can greatly improve the prognosis of patients with SLE [3].…”

Section: Introductionmentioning

confidence: 99%

Peripheral CD4CD8 Double Positive T Cells: A Potential Marker to Evaluate Kidney Damage Susceptibility During SLE

Chang¹,

Wang²,

Liu³

et al. 2020

Preprint

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Background: Lupus nephritis (LN) has a high incidence in Systemic lupus erythematosus (SLE) patients, but there is a lack of sensitive predictive markers and mechanisms. The purpose of the study is to reveal the association between the CD4+CD8+ double positive T lymphocytes (DPT) and lupus nephritis (LN), and to investigate the immune mechanism of LN. Methods: The study is composed of 395 samples from the General Hospital of Western Theater Command. Collected patients include SLE, lupus nephritis (LN), nephritic syndrome (NS) and nephritis patients. Peripheral blood lymphocyte subsets were performed by the Flow cytometry method. Biochemical measurements were performed in accordance with the recommendations proposed by national center for clinical laboratories.Results: The proportions of DPT cells in LN group were significantly higher than in SLE group (t=4.012, p<0.001), NS group (t=3.240, p=0.001) and nephritis group (t=2.57, p=0.011). In LN group, the risk of kidney damage increased significantly in the DPT cell proportion dependent manner. In cases of high DPT cells proportion, the risk of LN was 5.136 times higher than when the proportion DPT cell was within the normal range. Moreover, hypertriglyceridemia and hyperuricemia were also independent risk factors.Conclusion: The proportion of DPT cells was a potential marker to evaluate LN susceptibility. When assessing the risk of kidney damage during SLE with DPT cell proportion, we can effectively exclude the interference of NS and nephritis.

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Incidence and outcome of lupus nephritis in French Polynesia

Cited by 5 publications

References 0 publications

Epidemiology of End-Stage Kidney Disease in French Polynesia: A Plea for Standardized Diagnosis Workflow in Young Adults of First Nations People

Epidemiology of End-Stage Kidney Disease in French Polynesia: A Plea for Standardized Diagnosis Workflow in Young Adults of First Nations People

Peripheral CD4<sup>+</sup>CD8<sup>+</sup> double positive T cells: A potential marker to evaluate renal impairment susceptibility during systemic lupus erythematosus

Peripheral CD4CD8 Double Positive T Cells: A Potential Marker to Evaluate Kidney Damage Susceptibility During SLE

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