Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project

Bassetti, Matteo; Giacobbe, Daniele Roberto; Vena, Antonio; Trucchi, Cecilia; Ansaldi, Filippo; Antonelli, Massimo; Adámková, Václava; Alicino, Cristiano; Almyroudi, Maria Panagiota; Atchade, Enora; Azzini, Anna Maria; Carannante, Novella; Carnelutti, Alessia; Corcione, Silvia; Cortegiani, Andrea; Dimοpoulos, George; Dubler, Simon; García-Garmendia, José Luis; Girardis, Massimo; Cornely, Oliver A.; Ianniruberto, Stefano; Kullberg, Bart Jan; Lagrou, Katrien; Bihan, Clément Le; Luzzati, Roberto; Malbrain, Manu L N G; Merelli, Maria; Marques, Ana; Martín‐Loeches, Ignacio; Mesini, Alessio; Paiva, José Artur; Peghin, Maddalena; Raineri, Santi Maurizio; Rautemaa‐Richardson, Riina; Schouten, Jeroen; Brugnaro, Pierluigi; Spapen, Herbert D.; Tasioudis, Polychronis; Timsit, Jean‐François; Tisa, Valentino; Tumbarello, Mario; Berg, CP; Veber, Benoît; Venditti, Mario; Voiriot, Guillaume; Wauters, Joost; Montravers, Philippe

doi:10.1186/s13054-019-2497-3

Cited by 142 publications

(134 citation statements)

References 12 publications

(16 reference statements)

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“…The annual incidence of candidemia for the Netherlands is calculated to be 2.61 per 100,000 population. In Europe 26 and globally, 27 5.52 and 6.87 episodes per 1000 ICU admissions are diagnosed with Candida bloodstream infections, respectively. Candida peritonitis (intra‐abdominal candidiasis) was set to the European average of 1.84 episodes per 1000 ICU patients 26 .…”

Section: Methodsmentioning

confidence: 99%

“…In Europe 26 and globally, 27 5.52 and 6.87 episodes per 1000 ICU admissions are diagnosed with Candida bloodstream infections, respectively. Candida peritonitis (intra‐abdominal candidiasis) was set to the European average of 1.84 episodes per 1000 ICU patients 26 . We assumed that 6% of women aged 16‐50 had recurrent vulvo‐vaginal candidiasis 28‐30 .…”

Section: Methodsmentioning

confidence: 99%

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Burden of serious fungal infections in the Netherlands

Buil

Meijer

Denning

et al. 2020

Mycoses

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Background: Fungal diseases have an ever-increasing global disease burden, although regional estimates for specific fungal diseases are often unavailable or dispersed.Objectives: Here, we report the current annual burden of life-threatening and debilitating fungal diseases in the Netherlands. Methods:The most recent available epidemiological data, reported incidence and prevalence of fungal diseases were used for calculations. Results:Overall, we estimate that the annual burden of serious invasive fungal infections in the Netherlands totals 3 185 patients, including extrapulmonary or disseminated cryptococcosis (n = 9), pneumocystis pneumonia (n = 740), invasive aspergillosis (n = 1 283), chronic pulmonary aspergillosis (n = 257), invasive Candida infections (n = 684), mucormycosis (n = 15) and Fusarium keratitis (n = 8). Adding the prevalence of recurrent vulvo-vaginal candidiasis (n = 220 043), allergic bronchopulmonary aspergillosis (n = 13 568) and severe asthma with fungal sensitisation (n = 17 695), the total debilitating burden of fungal disease in the Netherlands is 254 491 patients yearly, approximately 1.5% of the country's population. Conclusion:We estimated the annual burden of serious fungal infections in the Netherlands at 1.5% of the population based on previously reported modelling of fungal rates for specific populations at risk. With emerging new risk groups and increasing reports on antifungal resistance, surveillance programmes are warranted to obtain more accurate estimates of fungal disease epidemiology and associated morbidity and mortality. K E Y W O R D Saspergillosis, candidemia, cryptococcosis, epidemiology, mucormycosis, pneumocystis

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Burden of serious fungal infections in the Netherlands

Buil

Meijer

Denning

et al. 2020

Mycoses

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“…Despite important and effective efforts have been made for reducing its unfavourable impact on patients’ health, candidaemia remains associated with high mortality and increased costs worldwide . Overall, Candida spp.…”

Section: Introductionmentioning

confidence: 99%

“…Despite important and effective efforts have been made for reducing its unfavourable impact on patients' health, candidaemia remains associated with high mortality and increased costs worldwide. [1][2][3][4][5] Overall, Candida spp. are the fourth to seventh more frequent cause of healthcare-associated bloodstream infections, with increasing incidence over time.…”

Section: Introductionmentioning

confidence: 99%

Changes in the relative prevalence of candidaemia due to non‐albicans Candida species in adult in‐patients: A systematic review, meta‐analysis and meta‐regression

Giacobbe

Maraolo

Simeon

et al. 2020

Mycoses

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Summary Background Candidaemia remains associated with high mortality and increased costs worldwide. Objective To assess the changes over time in the relative prevalence of non‐albicans candidaemia (NAC). Methods A systematic review, meta‐analysis and meta‐regression were performed. Observational studies investigating the epidemiology of consecutive, non‐selected, candidaemia episodes were included. Two separated analyses were conducted: (a) whole hospital analysis and (b) intensive care unit (ICU) analysis. Results Starting from an initial total of 7726 records, 220 studies fulfilled inclusion criteria. The pooled prevalence of NAC in whole hospital analysis was 49.5% (95% confidence intervals [CI] 48.0‐51.1, I2 93.1%), while the pooled prevalence in ICU analysis was 50.6% (95% CI 46.6‐54.6; I2 86.7%). In meta‐regression, a progressive increase in NAC prevalence was observed in whole hospital analysis, although it explained only a small portion of between‐study variance (estimated yearly prevalence change +0.3%, 95% CI from +0.1% to +0.5%, P = .003; adjusted R2 3.42%) and was observed only in some continents in subgroup analyses. No relevant changes over time were observed in NAC prevalence for ICU studies. Conclusions We registered an increasing trend in the relative prevalence of NAC, which, nonetheless, seems to be limited to some continents and to contribute only minimally to explain the observed differences in NAC prevalence across studies.

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“…Most interestingly, sepsisassociated mortality in patients suffering from an IFI is increased in comparison to non-IFI patients and amounts up to 42% for Candida spp. and is even higher in patients presenting with an IA [17][18][19].…”

Section: Introductionmentioning

confidence: 91%

Soluble Intercellular Adhesion Molecule- (sICAM-) 1, Thrombospondin-1, and Vinculin for the Identification of Septic Shock Patients Suffering from an Invasive Fungal Infection

Decker

Incamps²,

Sigl

et al. 2020

Mediators of Inflammation

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Background. Nowadays, invasive fungal infections (IFI) are of increasing importance and associated with an increased mortality. However, reliable diagnostic tools for the identification of patients suffering from an IFI are rare and associated with relevant weaknesses. Methods. Within this secondary analysis of an observational clinical study, an innovative biomarker panel (consisting of 62 biomarkers in total) was screened for the identification of septic shock patients suffering from an IFI. Fungal growth in blood cultures, intraoperative swabs, and Aspergillus spp. in deep respiratory tract specimens with accompanying pulmonary infiltrates were classified as infection, whereas Candida spp. in the respiratory tract or in fluids from drainages were classified as colonization. Plasma samples of 50 septic shock patients at six predefined timepoints within a period of 28 days following the onset of septic shock were available. Results. In total, 11 out of the 50 patients (22%) were shown to suffer from an IFI, whereas 22 patients (44%) presented with a fungal colonization. Within the presented biomarker panel, plasma levels of soluble intercellular adhesion molecule-(sICAM-) 1, thrombospondin-1, and vinculin were shown to be the most promising. sICAM-1 was shown to be increased in patients with an IFI, whereas thrombospondin-1 and vinculin revealed decreased plasma levels as compared to colonized patients as well as patients without any fungal findings at any time. Conclusion. Plasmatic measurements of sICAM-1, thrombospondin-1, and vinculin may help to facilitate the diagnosis of an IFI in human septic shock and to identify patients with an increased risk for an IFI. This trial is registered with DRKS00005463.

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Incidence and outcome of invasive candidiasis in intensive care units (ICUs) in Europe: results of the EUCANDICU project

Cited by 142 publications

References 12 publications

Burden of serious fungal infections in the Netherlands

Burden of serious fungal infections in the Netherlands

Changes in the relative prevalence of candidaemia due to non‐albicans Candida species in adult in‐patients: A systematic review, meta‐analysis and meta‐regression

Soluble Intercellular Adhesion Molecule- (sICAM-) 1, Thrombospondin-1, and Vinculin for the Identification of Septic Shock Patients Suffering from an Invasive Fungal Infection

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