Incidence and natural history of challenge‐proven cow's milk allergy in European children – EuroPrevall birth cohort

Schoemaker, A. A.; Sprikkelman, A. B.; Grimshaw, Kate; Roberts, Graham; Grabenhenrich, Linus; Rosenfeld, Leonard S.; Siegert, Sandy; Dubakiene, R.; Rudzevičienė, Odilija; Reche, Marta; Fiandor, Ana; Papadopoulos, Nikolaos G.; Malamitsi-Puchner, A; Fiocchi, Alessandro; Dahdah, Lamia; Sigurdardottir, Sigurveig; Clausen, Michael; Stańczyk-Przyłuska, Anna; Zeman, Krzysztof; Mills, E. N. Clare; McBride, Doreen; Keil, Thomas; Beyer, Kirsten

doi:10.1111/all.12630

Cited by 372 publications

(396 citation statements)

References 24 publications

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“…A wide range of CMA resolution rates has been reported from studies examining the natural history of CMA in different countries (6,9,13). In 9 European countries, 69% of children with CMA tolerated cow's milk one year after diagnosis, and all children with non IgE-mediated CMA and 57% of those with IgE-mediated CMA did so (14). A large cohort of 512 infants and children with CMA ranging from 3 to 15 months of age at 5 areas of the USA demonstrated a resolution rate of about 50% by age 5 (15).…”

Section: Discussionmentioning

confidence: 99%

IgE-Mediated Cow’s Milk Allergy in Iranian Infants and Children: Predictive Factors of Early Tolerance

2018

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Background: The majority of infants and children with cow's milk allergy will grow out of their allergy after a few years. The aim of this study was to identify the natural course of cow's milk allergy in infants and children during a follow-up of 18 months and also the predictive factors for its outgrowing. Methods: This prospective cross-sectional study included infants and children with IgE-mediated cow's milk allergy. Demographic data, clinical manifestations and probable predictive factors were recorded. Skin prick tests were done with commercial extracts of cow's milk, egg, fish, nuts and wheat on arrival. These infants and children were followed for 18 months and resolution was established by successful ingestion of cow's milk. The collected data were analyzed using SPSS version 22.0. Descriptive statistics, student's t-test or Mann-Whitney U-test and Chi-square test were used; a P < 0.05 was considered statistically significant. Results: Forty-nine infants and children (33 boys and 16 girls) with IgE-mediated cow's milk allergy presentation ranged in age from

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Section: Discussionmentioning

confidence: 99%

IgE-Mediated Cow’s Milk Allergy in Iranian Infants and Children: Predictive Factors of Early Tolerance

2018

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“…They indicate that the incidence of IgE-mediated CMA is less than anticipated: 0.41% (54 infants over 13 019) in Israel [5] and 0.46% (55 over 12,049) in the European community [6]. It was contended that too strict definitions may underestimate the incidence of CMA [7].…”

Section: Epidemiology and Natural History Of Cmamentioning

confidence: 99%

“…It was contended that too strict definitions may underestimate the incidence of CMA [7]. In any case, the condition presents an early resolution in the majority of cases, in particular the non-IgEmediated forms [5,6,8] 3. Non-IgE-mediated CMA and its gastrointestinal manifestations CMA is a spectrum of conditions ranging from the immediate.…”

Section: Epidemiology and Natural History Of Cmamentioning

confidence: 99%

What’s next for DRACMA?

Dahdah

Fierro

Mennini

et al. 2018

Expert Review of Clinical Immunology

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“…1 A alergia às proteínas do leite de vaca (APLV) é a alergia alimentar mais frequente em idade pediátrica, 2 afetando menos de 1% das crianças nos primeiros dois anos de vida. 3 Apesar da maioria das crianças resolver espontaneamente a APLV, dados recentes mostram que os quadros clínicos tendem a ser mais persistentes, com taxas de resolução de apenas 19, 42, 64 e 79%, em crianças com idades de 4, 8, 12 e 16 anos, respetivamente. 4 A abordagem clássica da alergia alimentar passa pela evicção rigorosa do alimento e tratamento sintomático dos episódios acidentais.…”

Section: Introductionunclassified

Alergia às Proteínas do Leite de Vaca: Uma Nova Era

García¹,

Mota²,

Piedade³

et al. 2016

Gaz Med

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A alergia às proteínas do leite de vaca apresenta uma prevalência, gravidade e persistência crescentes. A dieta de evicção é difícil de cumprir e as reações adversas potencialmente graves associadas à ingestão acidental do alimento são frequentes. Discute-se o caso clínico de uma criança de seis anos com história pessoal de alergia às proteínas do leite de vaca desde os três meses de vida, com vários episódios de anafilaxia por ingestão acidental de leite de vaca. Aos quatro anos foi submetida, com sucesso, a protocolo de indução de tolerância ao leite de vaca, permitindo-lhe atualmente uma dieta livre. Esta estratégia terapêutica mostra-se revolucionária por permitir modificar a história natural da alergia às proteínas do leite de vaca grave e persistente, com impacto muito positivo na qualidade de vida dos doentes e da sua família. PALAVRAS-CHAVE: Criança; Hipersensibilidade a Leite; Proteínas do Leite/efeitos adversos ABSTRACT Allergy to cow's milk proteins is common, serious and of growing persistence. A milk-free diet is difficult to comply with and

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Incidence and natural history of challenge‐proven cow's milk allergy in European children – EuroPrevall birth cohort

Cited by 372 publications

References 24 publications

IgE-Mediated Cow’s Milk Allergy in Iranian Infants and Children: Predictive Factors of Early Tolerance

IgE-Mediated Cow’s Milk Allergy in Iranian Infants and Children: Predictive Factors of Early Tolerance

What’s next for DRACMA?

Alergia às Proteínas do Leite de Vaca: Uma Nova Era

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