Incidence- and Mortality-Related Risk Factors of Acute Kidney Injury Requiring Hemofiltration Treatment in Patients Undergoing Cardiac Surgery: A Single-Center 6-Year Experience

Kowalik, Maciej Michał; Lango, Romuald; Klajbor, Katarzyna; Musiał-Świątkiewicz, Violetta; Kołaczkowska, Magdalena; Pawlaczyk, Rafał; Rogowski, Jan

doi:10.1053/j.jvca.2010.12.011

Cited by 35 publications

(31 citation statements)

References 26 publications

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“…This finding corresponds with a recent Brazilian study, which identified the same variable in association with early mortality after CPB cardiac surgery (Hajjar et al, 2013). The two postoperative variables associated with 30-day mortality, elevated creatine phosphokinase, which is indicative of peri-operative MI (Zaidi et al, 1999;Thygesen et al, 2007), and acute kidney failure with renal replacement therapy (Kowalik et al, 2011), are already well-known risk factors for early postoperative mortality after cardiac surgery. Other variables were associated with greater risk of death within the first five years after a successful cardiac surgery.…”

Section: Discussionsupporting

confidence: 89%

Clinical, biochemical and genetic risk factors for 30-day and 5-year mortality in 518 adult patients subjected to cardiopulmonary bypass during cardiac surgery - the INFLACOR study.

Kowalik¹,

Lango²,

Siondalski³

et al. 2018

Acta Biochim Pol

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There is increasing evidence that genetic variability influences patients' early morbidity after cardiac surgery performed using cardiopulmonary bypass (CPB). The use of mortality as an outcome measure in cardiac surgical genetic association studies is rare. We publish the 30-day and 5-year survival analyses with focus on pre-, intra-, postoperative variables, biochemical parameters, and genetic variants in the INFLACOR (INFLAmmation in Cardiac OpeRations) cohort. In a prospectively recruited cohort of 518 adult Polish Caucasians, who underwent cardiac surgery in which CPB was used, the clinical data, biochemical parameters, IL-6, soluble ICAM-1, TNFα, soluble E-selectin, and 10 single nucleotide polymorphisms were evaluated for their association with 30-day and 5-year mortality. The 30-day mortality was associated with: pre-operative prothrombin international normalized ratio, intra-operative blood lactate, postoperative serum creatine phosphokinase, and acute kidney injury requiring renal replacement therapy (AKI-RRT) in logistic regression. Factors that determined the 5-year survival included: pre-operative NYHA class, history of peripheral artery disease and severe chronic obstructive pulmonary disease, intra-operative blood transfusion; and postoperative peripheral hypothermia, myocardial infarction, infection, and AKI-RRT in Cox regression. Serum levels of IL-6 and ICAM-1 measured three hours after the operation were associated with 30-day and 5-year mortality, respectively. The ICAM1 rs5498 was associated with 30-day and 5-year survival with borderline significance. Different risk factors determined the early (30-day) and late (5-year) survival after adult cardiac surgery in which cardiopulmonary bypass was used. Future genetic association studies in cardiac surgical patients should account for the identified chronic and perioperative risk factors.

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Section: Discussionsupporting

confidence: 89%

Clinical, biochemical and genetic risk factors for 30-day and 5-year mortality in 518 adult patients subjected to cardiopulmonary bypass during cardiac surgery - the INFLACOR study.

Kowalik¹,

Lango²,

Siondalski³

et al. 2018

Acta Biochim Pol

Self Cite

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show abstract

“…The incidence of AKI in this study was 63.9%, with 19.6% requiring dialysis, which is in good agreement with our previous study . The incidence was higher than other aortic surgery reports, because of different disease groups and surgical methods . In this study, only AAAD patients with Sun's procedure were enrolled.…”

Section: Resultsmentioning

confidence: 95%

“…2 The incidence was higher than other aortic surgery reports, because of different disease groups and surgical methods. 22,23 In this study, only AAAD patients with Sun's procedure were enrolled. The different results also were the result of the different classification system for AKI.…”

Section: Discussionmentioning

confidence: 99%

Retracted: Early Detection of Postoperative Acute Kidney Injury in Acute Stanford Type A Aortic Dissection With Doppler Renal Resistive Index

Qin

Chen

et al. 2017

J of Ultrasound Medicine

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“…In the other 27 studies (2536 survivors), a single initial RRT modality was applied to all patients. This modality was IRRT in 11 of these studies (644 survivors) [42][43][44][45][46][47][48][49][50][51][52] and CRRT in 16 (1892 survivors) [53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68].…”

Section: Resultsmentioning

confidence: 99%

Choice of renal replacement therapy modality and dialysis dependence after acute kidney injury: a systematic review and meta-analysis

et al. 2013

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Incidence- and Mortality-Related Risk Factors of Acute Kidney Injury Requiring Hemofiltration Treatment in Patients Undergoing Cardiac Surgery: A Single-Center 6-Year Experience

Cited by 35 publications

References 26 publications

Clinical, biochemical and genetic risk factors for 30-day and 5-year mortality in 518 adult patients subjected to cardiopulmonary bypass during cardiac surgery - the INFLACOR study.

Clinical, biochemical and genetic risk factors for 30-day and 5-year mortality in 518 adult patients subjected to cardiopulmonary bypass during cardiac surgery - the INFLACOR study.

Retracted: Early Detection of Postoperative Acute Kidney Injury in Acute Stanford Type A Aortic Dissection With Doppler Renal Resistive Index

Choice of renal replacement therapy modality and dialysis dependence after acute kidney injury: a systematic review and meta-analysis

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