Incidence and mortality of kidney cancer: temporal patterns and global trends in 39 countries

Wong, Martin Cs; Goggins, William B.; Yip, Benjamin H K; Fung, Francis; Leung, Colette; Fang, Yuan; Wong, Samuel Yeung‐Shan; Ng, Chi Fai

doi:10.1038/s41598-017-15922-4

Cited by 101 publications

(104 citation statements)

References 30 publications

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“…RCC mortality continues to rise in Eastern Europe, however [4]. Renal cancer contributes to a greater average number of years of life lost (a measure of cancer burden dependent on patient age at death and the number of deaths at each age) than both colorectal and prostate cancer [13, 14].…”

Section: Resultsmentioning

confidence: 99%

Epidemiology and screening for renal cancer

et al. 2018

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PurposeThe widespread use of abdominal imaging has affected the epidemiology of renal cell carcinoma (RCC). Despite this, over 25% of individuals with RCC have evidence of metastases at presentation. Screening for RCC has the potential to downstage the disease.MethodsWe performed a literature review on the epidemiology of RCC and evidence base regarding screening. Furthermore, contemporary RCC epidemiology data was obtained for the United Kingdom and trends in age-standardised rates of incidence and mortality were analysed by annual percentage change statistics and joinpoint regression.ResultsThe incidence of RCC in the UK increased by 3.1% annually from 1993 through 2014. Urinary dipstick is an inadequate screening tool due to low sensitivity and specificity. It is unlikely that CT would be recommended for population screening due to cost, radiation dose and increased potential for other incidental findings. Screening ultrasound has a sensitivity and specificity of 82–83% and 98–99%, respectively; however, accuracy is dependent on tumour size. No clinically validated urinary nor serum biomarkers have been identified. Major barriers to population screening include the relatively low prevalence of the disease, the potential for false positives and over-diagnosis of slow-growing RCCs. Individual patient risk-stratification based on a combination of risk factors may improve screening efficiency and minimise harms by identifying a group at high risk of RCC.ConclusionThe incidence of RCC is increasing. The optimal screening modality and target population remain to be elucidated. An analysis of the benefits and harms of screening for patients and society is warranted.Electronic supplementary materialThe online version of this article (10.1007/s00345-018-2286-7) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Epidemiology and screening for renal cancer

et al. 2018

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“…The used antitumor drugs have some drawbacks: a toxic effect on healthy organs and tissues of the body, as well as the development of tumor resistance to treatment. Therefore, the search for new, more safe and effective medicines is an important challenge today [1,2].…”

Section: Introductionmentioning

confidence: 99%

The apoptotic activity of flavonoid-containing Gratiola officinalis extract in cell cultures of human kidney cancer

Polukonova¹,

Navolokin²,

Bucharskaya³

et al. 2018

Russ Open Med J

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Objective -The discovery of the apoptosis-inducing effects of flavonoid vagonin allowed to make an assumption of existence of similar effect in others flavonoids. This study is devoted to the effects of Gratīola officinālis extract on cell culture of the human kidney cancer.Methods -Cell cultures of human kidney carcinoma -Caki-1 and SN12c were used in the study. The cells were stained with Hoechat 33258 dye. The number of living cells, cells in a state of apoptosis and mitosis were counted. The Cramer-Welch criterion (T) was used to compare the obtained data.Results -The activation of apoptosis was noted at all concentrations of the Gratiola officinalis L. extract during the first day of exposure. The apoptotic activity increased with increasing of extract concentration. After 48 hours, this activity was maintained only at a Gratiola officinalis L. extract concentration of 0.9 mg/ml. After 24 hours, the apoptotic activity of the extract was more expressed in the culture of CaKi-1. However, after 48 hours the extract induces more pronounced apoptosis in the culture of Sn12c cells. The cytotoxic activity of the extract was not differ after 24 hours in both cultures, after 48 hours it was more pronounced in the culture of CaKi-1. Conclusion -We revealed a pronounced antitumor and apoptotic activity of the Gratiola officinalis L. extract against the cultures of the kidney cancer Caki-1 and Sn12c. Apoptosis of tumor cells can be manifested in the form of pycnosis of the nucleus, the formation of apoptotic bodies and the emergence of cellular debris resulting from complete degradation of tumor cells. The apoptotic activity of the Gratiola officinalis extract depends on their concentration.

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“…In the current study, there was a 20% increase in incidence from 2011 to 2015. The prevalence rates of renal pelvis and ureter cancers were 0.42 and 0.4, respectively, confirming that transitional cell carcinomas of the ureter and renal pelvis are relatively uncommon (3,(21)(22)(23)(24).…”

mentioning

confidence: 64%

“…Renal parenchyma cancer is the predominant kidney cancer, mainly of the adenocarcinoma cell type (renal cell cancer). The highest incidence rates were observed in Eastern Europe and North America while its mortality rates were the highest in European countries with an estimated economic burden of 1.6 billion dollars (21). Renal pelvis cancers are mostly of the transitional cell type (8).…”

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confidence: 99%

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Prevalence of Kidney, Renal Pelvis, and Ureter Cancers in Isfahan Province, Iran

Tolou-Ghamari

2019

J Arch Mil Med

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Background: According to the literature, the incidence of kidney cancer is on the rise worldwide. Objectives: The aim of this investigation was to provide the data of period prevalence of kidney, renal pelvis, and ureter cancers in the general population including the military or non-military population in Isfahan province, Iran. Methods: Data associated with cancers of the kidney, renal pelvis, and ureter were obtained from the Isfahan Cancer Registry between 2011 and 2015. Kidney, renal pelvis, and ureter cancers were defined by topography codes of C64, C65, and C66, respectively. Results: There were 404, 21, and 18 registered cases of kidney, renal pelvis, and ureter cancers, respectively, corresponding to a PP of 8.9 per 100000 population. The mean ± SD of age was 56.6 ± 16.8 years in patients. The age of kidney cancer patients was more than 50 years in 51% of the cases. The incidences were 2per 100000 population. The death data confirmed 14% and 86% mortality associated with kidney cancer and renal pelvis, respectively. Conclusions: The incidence rate of kidney cancer showed increases by 20%. The data confirmed high mortality associated with cancer of renal pelvis. In order to decrease cancer incidence, healthcare planning should be based on military management together with a well-structured pharmacotherapy strategy.

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Incidence and mortality of kidney cancer: temporal patterns and global trends in 39 countries

Cited by 101 publications

References 30 publications

Epidemiology and screening for renal cancer

Epidemiology and screening for renal cancer

The apoptotic activity of flavonoid-containing Gratiola officinalis extract in cell cultures of human kidney cancer

Prevalence of Kidney, Renal Pelvis, and Ureter Cancers in Isfahan Province, Iran

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