Incidence and Long-term Outcome of Young Patients With Gastric Carcinoma According to Sex

Kim, Jong Han; Boo, Yoon Jung; Park, Joong Min; Kim, Seungjoo; Kim, Chong Suk; Mok, Young Jae

doi:10.1001/archsurg.143.11.1062

Cited by 34 publications

(37 citation statements)

References 27 publications

(43 reference statements)

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“…OR odds ratio; CI confidence interval * The multivariate logistic regression test was used age affects lymph node metastasis in poorly differentiated EGC and signet ring cell EGC [18][19][20]. However, our study shows that if a patient with poorly differentiated EGC was younger than 45 years, the risk of lymph node metastasis was 2.6 times higher than that in a patient older than 45 years.…”

Section: \00001mentioning

confidence: 60%

Early gastric cancer of signet ring cell carcinoma is more amenable to endoscopic treatment than is early gastric cancer of poorly differentiated tubular adenocarcinoma in select tumor conditions

et al. 2011

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Section: \00001mentioning

confidence: 60%

Early gastric cancer of signet ring cell carcinoma is more amenable to endoscopic treatment than is early gastric cancer of poorly differentiated tubular adenocarcinoma in select tumor conditions

et al. 2011

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“…However, some authors indicate that the reason lies in co-morbidities and deaths not related to cancer. On the other hand, there are reports that suggest poorer prognosis in younger patients in whom undifferentiated forms of gastric cancer are more common [24].…”

Section: Discussionmentioning

confidence: 99%

Risk Factors and Survival of Gastric Cancer Patients Following Curative Stomach Resection: Analysis of a Homogeneous Population of Patients in Warsaw, Poland

Gierej

Radziszewski

2012

Viszeralmedizin

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Background: The aim of the study was to evaluate the prognostic factors for survival in a homogeneous population of gastric cancer patients in Warsaw, Poland. Patients and Methods: In a 2-year period, 167 inhabitants of Warsaw with stomach cancer underwent curative gastric resection. The overall 5-year survival rates of the patients were assessed. The pathologic stage of the disease was assessed according to the Tumor Node Metastasis (TNM) classification. Prognostic factors were determined by multivariate analysis. Results: Overall survival rates were equal to 64, 46, and 31% at 12, 24, and 60 months, respectively. Younger age (20–59 years) was an independent factor associated with better survival. In multivariate analysis, advanced tumor stage T3–T4 vs. T1–T2 (T3: hazard ratio (HR) 2.49, 95% confidence interval (CI) 1.44–4.31; T4: HR 2.84, 95% CI 1.25–6.47), lymph node involvement N+ vs. N0 (HR 1.74, 95% CI 1.1–2.78), positive resection margin status R1 vs. R0 (HR 1.78, 95% CI 1.06–2.98), and metastatic lymph node ratio >50% vs. <50% (HR 1.85, 95% CI 1.17–2.91) were associated with poorer prognosis. Patients’ sex and location of the tumor had no impact on overall survival. According to our results, the entire study population showed a low percentage of early gastric cancer (3.5%). Although there were twice as many male than female patients, gender had no impact on overall survival. Conclusion: Factors such as advanced tumor stage (T3–T4), lymph node involvement, positive resection margins, and a higher metastatic lymph node ratio were associated with poorer prognosis. The impact of the latter factor on survival indirectly suggests that extended lymphadenectomy could be a predictor for better prognosis.

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“…Kim et al [15] reported that young women with gastric cancer showed unfavorable prognoses, and Sato et al [16] reported that survival after surgery for gastric cancer was slightly more favorable in women. Wichmann et al [17] reported that women with colorectal cancer had more favorable outcomes than men.…”

Section: Discussionmentioning

confidence: 99%

Gender differences in clinicopathologic features and outcomes of esophageal cancer patients treated surgically

et al. 2011

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Background We investigated the clinicopathologic features and long-term outcomes after surgery of Japanese women with esophageal cancer in comparison to those of men. Methods A total of 136 patients with esophageal cancer were surgically treated between 1996 and 2008 (22 [16.2%] women and 114 men). Gender differences in these patients were retrospectively investigated. Results Women undergoing esophagectomy for esophageal cancer showed lower frequencies of cigarette smoking (p \ 0.0001) and alcohol consumption (p \ 0.0001) compared to men. Preoperative co-morbidities in women were fewer than those in men (p \ 0.001). Regarding the clinicopathologic features of esophageal cancer, women frequently had superficial cancer and no node metastasis (p \ 0.05). Women had lower-level morbidity after surgery (p \ 0.05), but no mortality after surgery was observed in men or women. Although there was no difference in other causes of death after surgery between them, recurrence/metastasis after surgery was more frequent in men than women (p \ 0.05). The 5-year survival rate after surgery was higher in women than men (p \ 0.05), but gender difference was not an independent prognostic factor. Conclusions Significant gender differences in patients with esophagectomy were observed regarding the preoperative condition, clinicopathologic features, postoperative condition, and long-term outcome after surgery. It was suggested that the more favorable outcome of women with esophageal cancer was associated with their earlier stages of esophageal cancer.

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Incidence and Long-term Outcome of Young Patients With Gastric Carcinoma According to Sex

Abstract: Background: We investigated the clinicopathological features and evaluated the prognostic impact of age and sex on patients with gastric cancer.

Cited by 34 publications

References 27 publications

Early gastric cancer of signet ring cell carcinoma is more amenable to endoscopic treatment than is early gastric cancer of poorly differentiated tubular adenocarcinoma in select tumor conditions

Early gastric cancer of signet ring cell carcinoma is more amenable to endoscopic treatment than is early gastric cancer of poorly differentiated tubular adenocarcinoma in select tumor conditions

Risk Factors and Survival of Gastric Cancer Patients Following Curative Stomach Resection: Analysis of a Homogeneous Population of Patients in Warsaw, Poland

Gender differences in clinicopathologic features and outcomes of esophageal cancer patients treated surgically

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