Incidence and In‐Hospital Mortality of Acute Kidney Injury (AKI) and Dialysis‐Requiring AKI (AKI‐D) After Cardiac Catheterization in the National Inpatient Sample

Brown, Jeremiah R.; Rezaee, Michael E.; Nichols, Elizabeth L.; Marshall, Emily; Siew, Edward D.; Matheny, Michael E.

doi:10.1161/jaha.115.002739

Cited by 36 publications

(48 citation statements)

References 43 publications

(110 reference statements)

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“…Furthermore, our data are concordant with those from the coronary intervention experience where AKI with dialysis has been strongly associated with inhospital mortality . In the present analysis, AKI‐D increased mortality by 2.5 times over AKI alone.…”

Section: Discussionsupporting

confidence: 90%

“…Furthermore, our data are concordant with those from the coronary intervention experience where AKI with dialysis has been strongly associated with inhospital mortality. 14 In the present analysis, AKI-D increased mortality by 2.5 times over AKI alone. These findings emphasize that while lower extremity endovascular procedures are generally considered low risk, an AKI event is significant and more so if the procedure is associated with need for dialysis.…”

Section: Risk Factor Associations and Mortalitymentioning

confidence: 43%

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Acute kidney injury in patients undergoing endovascular therapy for critical limb ischemia

Prasad

Hughston

Michalek

et al. 2019

Cathet Cardio Intervent

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Background Similar to coronary angiography and interventions, patients undergoing percutaneous treatment of lower extremity peripheral arterial disease are also at risk of acute kidney injury (AKI). The incidence, risk factors associations, need for dialysis and inhospital mortality related to AKI in patients with critical limb ischemia (CLI) following endovascular therapy is poorly defined. Objectives The purpose of this study was to analyze data from the National Inpatient Sample (NIS) to determine the aforementioned outcomes in patients with CLI. Methods Using the full NIS admission dataset from 2003 through 2012, ICD‐9 codes relevant to comorbid conditions, procedure codes, composite codes for AKI, and inhospital mortality were analyzed using multivariate models. Results A total of 273,624 patients were included with a mean age of 70.0 ± 27.4 years, 46.0% were female, 57.2% had diabetes, 43.4% had coronary artery disease (CAD), and 29.2% had chronic kidney disease (CKD). The overall rate of AKI was 10.4%, and there was a temporal rise over the analysis period in AKI incidence (p < .001). Age, diabetes, CKD, and heart failure were all associated with AKI (p < .0001). The inhospital mortality rate in the patients with AKI declined over time but was higher than in patients without AKI (6.0% vs. 1.4%), p < .0001. The mortality rate was substantially higher in patients with AKI requiring dialysis as compared to AKI not requiring dialysis (13.4% vs. 5.6%), p < .0001. Conclusions AKI is associated with age, CKD, and heart failure. The incidence of AKI following endovascular therapy for CLI is rising and independently associated with inhospital mortality.

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Section: Discussionsupporting

confidence: 90%

Section: Risk Factor Associations and Mortalitymentioning

confidence: 43%

Acute kidney injury in patients undergoing endovascular therapy for critical limb ischemia

Prasad

Hughston

Michalek

et al. 2019

Cathet Cardio Intervent

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“…Additional hospitalization and CDI-related complications variables were compiled by extracting the ICD-9-CM codes as outlined in Table S1. 3,[12][13][14] The ICU admission variable was synthesized using surrogate markers (Table S1) of invasive support/monitoring that traditionally involve an ICU setting. 12 Hospitalization costs were calculated as previously described in the literature, 15 finally being adjusted for annual inflation, with the reference year 2012.…”

Section: Methodsmentioning

confidence: 99%

Acute kidney injury impact on inpatient mortality in Clostridium difficile infection: A national propensity‐matched study

Charilaou

Devani

John

et al. 2018

J of Gastro and Hepatol

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“…CIN is a complication recognized in both coronary angiography (CAG) and percutaneous coronary intervention (PCI) [2]. CIN defined as an increase in serum creatinine of 0.5 mg/dL (44 μmol/L) or a relative 25% increase from the baseline value and mostly during the period from 24 to 48 hours following intravascular administration of contrast media [3].…”

Section: Introductionmentioning

confidence: 99%

The Role of Serum Cystatin C in the Early Detection of Contrast-Induced Nephropathy after Coronary Intervention

Fj¹,

Mh²,

Ma³

et al. 2017

J Kidney

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Objective: Contrast induced nephropathy is the most common complication for both coronary angiography and percutaneous coronary intervention. The aim of the present study is to investigate the role of serum cystatin C among patients undergoing coronary angiography for earlier detection of contrast induced nephropathy. Materials and Methods:The study included 80 elective patients attending the cardiology center (48 males, 32 females). The study was conducted in cardiac catheterization unit at Al-Hussein Medical City/ Kerbala Health Directorate-Holy Kerbala, Iraq. Clinical examination and laboratory investigations were made before and 24 hours after angiography. These investigations include: serum creatinine, blood urea, estimated GFR and serum cystatin C.Results: According to the definition, contrast induced nephropathy occurred in 19 patients 23.8% with grade 0 to 2 of renal dysfunction. There were significant increments in serum creatinine, cystatin C and eGFR after 24 hours of angiography/angioplasty procedures p<0.001, 0.01 respectively. Receiver-operating characteristic analysis showed a higher area under the curve for creatinine 0.805 (95% CI=0.688, 0.921) p=0.001, 78.9% sensitivity and 60.7% specificity than serum cystatin C 0.777 (95% CI=0.673-0.881) P=0.001 sensitivity=78.9% and specificity=64%, a cutoff level of cystatin C>7 ng/ml. Conclusion:Cystatin C was a good biomarker for earlier diagnosis of contrast induced nephropathy when compared with blood urea and eGFR.

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Incidence and In‐Hospital Mortality of Acute Kidney Injury (AKI) and Dialysis‐Requiring AKI (AKI‐D) After Cardiac Catheterization in the National Inpatient Sample

Abstract: Background--Acute kidney injury (AKI) and dialysis-requiring AKI (AKI-D) are common, serious complications of cardiac procedures.

Cited by 36 publications

References 43 publications

Acute kidney injury in patients undergoing endovascular therapy for critical limb ischemia

Acute kidney injury in patients undergoing endovascular therapy for critical limb ischemia

Acute kidney injury impact on inpatient mortality in Clostridium difficile infection: A national propensity‐matched study

The Role of Serum Cystatin C in the Early Detection of Contrast-Induced Nephropathy after Coronary Intervention

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