Incidence and Impact of Adverse Drug Events in Pediatric Inpatients

Holdsworth, Mark T.; Fichtl, Richard E.; Behta, Maryam; Raisch, Dennis W.; Mendez-Rico, Elena; Adams, Alexa; Greifer, Melanie; Bostwick, Susan; Greenwald, Bruce M.

doi:10.1001/archpedi.157.1.60

Cited by 135 publications

(135 citation statements)

References 19 publications

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“…In hospitalized children, rates of preventable medication-related injuries ranged from 0.5% to 3.8%. 9,37 Children with cancer in our study in the home setting had a comparable or higher rate of medication-related preventable injuries than hospitalized children in other studies.…”

Section: Discussionmentioning

confidence: 49%

Medication Errors in the Home: A Multisite Study of Children With Cancer

et al. 2013

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OBJECTIVE: As home medication use increases, medications previously managed by nurses are now managed by patients and their families. Our objective was to describe the types of errors occurring in the home medication management of children with cancer. METHODS: In a prospective observational study at 3 pediatric oncology clinics in the northeastern and southeastern United States, patients undergoing chemotherapy and their parents were recruited from November 2007 through April 2011. We reviewed medical records and checked prescription doses. A trained nurse visited the home, reviewed medication bottles, and observed administration. Two physicians independently made judgments regarding whether an error occurred and its severity. Overall rates of errors were weighted to account for clustering within sites. RESULTS: We reviewed 963 medications and observed 242 medication administrations in the homes of 92 patients. We found 72 medication errors. Four errors led to significant patient injury. An additional 40 errors had potential for injury: 2 were life-threatening, 13 were serious, and 25 were significant. Error rates varied between study sites (40–121 errors per 100 patients); the weighted overall rate was 70.2 errors per 100 patients (95% confidence interval [CI]: 58.9–81.6). The weighted rate of errors with injury was 3.6 (95% CI: 1.7–5.5) per 100 patients and with potential to injure the patient was 36.3 (95% CI: 29.3–43.3) per 100 patients. Nonchemotherapy medications were more often involved in an error than chemotherapy. CONCLUSIONS: Medication errors were common in this multisite study of outpatient pediatric cancer care. Rates of preventable medication-related injuries in this outpatient population were comparable or higher than those found in studies of hospitalized patients.

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Section: Discussionmentioning

confidence: 49%

Medication Errors in the Home: A Multisite Study of Children With Cancer

et al. 2013

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“…Condition-specific discharges were identified with the instructions provided for each measure. [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] Depending on the measure, AHRQ's Clinical Classification System, 3M Health Information System's All Patient Refined Diagnosis Related Groups, or individual International Classification of Diseases, Ninth Revision, Clinical Modification, principal diagnosis and procedure codes were used (Supplemental Table 4). 52 …”

Section: Discharge Diagnoses and Quality Measuresmentioning

confidence: 99%

Recognizing Differences in Hospital Quality Performance for Pediatric Inpatient Care

2015

PEDIATRICS

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“…Foram identificadas taxas de seis eventos adversos ao medicamento por 100 admissões (76 eventos), e oito erros de medicação por 100 admissões (94 eventos). Concluiu-se que eventos adversos ao medicamento têm maior probabilidade de ocorrer em crianças com tempo prolongado de internação e recebendo maior número de medicamentos (32) . Num período de cinco anos, um dos maiores hospitais pediátricos no Reino Unido registrou a ocorrência de 195 erros medicação por meio de um sistema interno de notificação.…”

Section: Epidemiologia Dos Erros De Medicação Em Pediatriaunclassified

Erros de medicação em pediatria

Belela

Peterlini

2011

Rev. Bras. Enferm.

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RESUMOA segurança do paciente constitui problema de saúde pública, e erros com medicamentos são os mais freqüentes e graves. O artigo apresenta características epidemiológicas dos erros de medicação em diferentes áreas de atendimento pediátrico, e aponta estratégias de prevenção. Aproximadamente 8% das pesquisas sobre erros de medicação identificadas em bases de dados nacionais e internacionais referem-se à população pediátrica. Crianças apresentam maior vulnerabilidade à ocorrência de erros devido a fatores intrínsecos, destacando-se características anatômicas e fisiológicas; e extrínsecos, relativos à falta de políticas de saúde e da indústria farmacêutica voltadas ao atendimento de tais especificidades. As evidências apontam para a necessidade de implementação de estratégias de prevenção de erros de medicação, contribuindo para promover a segurança do paciente. descritores: Erros de medicação; Pediatria; Segurança; Qualidade da Assistência à Saúde. ABSTRACT Concerns regarding patient safety affect healthcare, and medication errors are the most frequent category of medical errors and linked with severe consequences. This study discusses epidemiologic characteristics of medication errors in pediatric patients and points out prevention strategies. Approximately 8% of the studies on the subject of medication errors identified in different national and international databases are distinctively related to the pediatric population. Children are vulnerable to medication errors due to intrinsic factors, such as proper anatomic and physiological characteristics; and due to extrinsic factors, with emphasis on the lack of public health politics and changes in the pharmaceutical industry to attend children's needs. The available evidences indicate, as imperative, the implementation of strategies to prevent medication errors, contributing to promote patient safety. Key words: Medication errors; Pediatric; Safety; Quality of Health Care. RESUMEN La seguridad del paciente es un problema de salud pública y los errores con medicamentos son los más frecuentes y más graves. Este artículo describe características epidemiológicas de errores de medicación en áreas de atención pediátrica y algunas estrategias de prevención. Aproximadamente 8% de las investigaciones sobre errores de medicación identificadas en las bases de datos nacionales e internacionales se refieren específicamente a niños. Los niños tienen mayor vulnerabilidad a la ocurrencia de errores debidos a factores intrínsecos, con destaque para características anatómicas y fisiológicas, e extrínsecos, en particular con respecto a falta de políticas sanitarias y de la industria farmacéutica orientada a la atención de tales características. Evidencias muestran la necesidad de aplicar estrategias para prevenir errores de medicación, promoviendo la seguridad del paciente. descriptores: Errores de medicación; Pediatría; Seguridad; Calidad de la Atención de Salud. erros de medicação em Pediatria

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Incidence and Impact of Adverse Drug Events in Pediatric Inpatients

Abstract: Both ADEs and potential ADEs are common among hospitalized children with greater disease burden and medication exposure. These findings suggest that these events were a consequence, rather than a cause, of more severe illness.

Cited by 135 publications

References 19 publications

Medication Errors in the Home: A Multisite Study of Children With Cancer

Medication Errors in the Home: A Multisite Study of Children With Cancer

Recognizing Differences in Hospital Quality Performance for Pediatric Inpatient Care

Erros de medicação em pediatria

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