Incidence and Epidemiology of Anal Cancer in the Multicenter AIDS Cohort Study

D’Souza, Gypsyamber; Wiley, Dorothy J.; Li, Xiuhong; Chmiel, Joan S.; Margolick, Joseph B.; Cranston, Ross D.; Jacobson, Lisa P.

doi:10.1097/qai.0b013e31817aebfe

Cited by 300 publications

(260 citation statements)

References 51 publications

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“…Before the HIV pandemic, the incidence of anal cancer in MSM 8 was approximately 35 per 100,000-a rate similar to that of cervical cancer before the initiation of Pap test screening. In HIV-positive MSM, the reported incidence rates range from 42 to 137 per 100,000 per year 2,[9][10][11][12] and are continuing to increase even with the use of highly active antiretroviral therapy (HAART) therapy. 2,12 In the population of MSM, both HIV-positive and negative men, prevalence rates of biopsy-proven highgrade AIN-the precursor lesion-are also remarkably high: approximately 50% in HIV-positive MSM and 25% in HIV-negative MSM have biopsy-proven highgrade AIN.…”

Section: Epidemiology and Pathogenesis Of Anal Cancermentioning

confidence: 99%

Anal cancer and cervical cancer screening: Key differences

Darragh

Winkler

2010

Cancer Cytopathology

192

203

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Cervical cancer and anal cancer share many similarities including causation by oncogenic human papillomaviruses; however, significant differences exist in their epidemiology, risk factors, biologic behavior, management, and treatment. Although rare, the incidence of anal cancer is alarmingly high and continues to increase in high-risk populations, particularly men who have sex with men regardless of their human immunodeficiency virus (HIV) status. There are no national screening guidelines for anal cancer. Using the success of cervical cancer screening as a model, anal cancer screening approaches apply anal cytology, highresolution anoscopy, and directed biopsy to guide treatment and management strategies. Although much has been learned about the natural history and epidemiology of anal intraepithelial neoplasia (AIN), the rate of progression of high-grade anal intraepithelial neoplasia (HGAIN) to invasive squamous cell carcinomas is not known. The impact of screening and treatment of HGAIN on morbidity and mortality from anal cancer are also unknown. Because the incidence of HGAIN and anal squamous cell carcinoma continue to increase, it is imperative to find pathways for effective screening, early detection, and therapeutic intervention. This article provides an overview of anal cancer screening while highlighting its differences from cervi- Compared with cervical cancer, anal cancer is rare. The National Cancer Institute estimates that 5260 patients will be diagnosed with anal cancer in 2010 and that 720 men and women will die of the disease. 1 Compare this to cervical cancer statistics in the United States for 2010: 12,200 will be diagnosed with cervical cancer and 4210 women will die and this is with successful opportunistic Papanicolaou (Pap) testing to screen for this cancer in the United States. Yet, in patients with the highest risk of anal cancer, its incidence was more than double that of cervical cancer prior to the initiation of Pap screening and is increasing, while rates for cervical cancer continue to decrease. As the incidence of anal carcinoma increases in populations at risk, cytologic screening, combined with early detection and treatment, has been proposed as a method to reduce the morbidity and mortality from invasive anal squamous cell carcinoma (ASCC).

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Section: Epidemiology and Pathogenesis Of Anal Cancermentioning

confidence: 99%

Anal cancer and cervical cancer screening: Key differences

Darragh

Winkler

2010

Cancer Cytopathology

192

203

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“…[10][11][12][13] Estos resultados son diferentes a los de Palefsky y colaboradores que en 1968, encontraron una prevalencia de 93 % de DNA del VPH en pacientes con VIH hombres que tienen sexo con hombres mediante estudio de reacción en cadena de la polimerasa; sin embargo no reportaron la frecuencia de NIA asociada al virus. 13 La fuerte correlación encontrada entre la citología y anoscopía suma evidencia a los resultados reportados por Mallari y colaboradores en su estudio retrospectivo de correlación entre citología y anoscopía en 285 sujetos de alto riesgo, cuya frecuencia fue del 66.5 % de displasia corroborada por biopsia, de ellas 42 presentaron neoplasia intraepitelial de alto grado.…”

Section: Discussionunclassified

Concordancia histopatológica entre la citología y la biopsia anal en hombres que tienen sexo con hombres portadores de VIH y neoplasia intraepitelial anal asociada a VPH

Ríos¹,

Cabezas

Sobarzo

2015

Rev. Med. UCSG

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ResumenObjetivo: determinar la concordancia de los resultados de la citología y la biopsia anal en hombres que tienen sexo con hombres (HSH) portadores de VIH y neoplasia intraepitelial anal (NIA) asociada a virus del papiloma humano (VPH). Materiales y métodos: estudio observacional transversal, de diciembre de 2011 a diciembre de 2013 para determinar la concordancia de los resultados de la citología y la biopsia anal en hombres que tienen sexo con hombres (HSH) portadores de VIH y NIA asociada a VPH en pacientes del hospital de Infectología del Centro Médico Nacional la Raza. Se realizó análisis estadísticos descriptivos. Resultados: se estudiaron 92 sujetos VIH positivos y VPH positivo, el reporte histopatológico definitivo de las biopsias anales fueron: neoplasia intraepitelial de bajo grado en 39 %, neoplasia intraepitelial de alto grado 4 %, células atípicas de significado incierto 3 %, normales en 27 %, con cambios inflamatorios reactivos en 23 % y muestras inadecuadas para el diagnóstico el 9 %. La concordancia observada entre los dos métodos diagnósticos fue de 0.90 según alfa de Crobanch. Conclusión: el grado de concordancia del 90 % de las biopsias y citologías anales, indica que son buenos métodos de seguimiento de los pacientes infectados con VIH y VPH, y permite detectar en forma oportuna lesiones precancerígenas, brindando diagnóstico y tratamiento oportuno.PALABRAS CLAVE: neoplasias, carcinoma in situ, infección por Papillomavirus, VIH, conducta sexual. Abstract Objective: to determine the matching of the results of cytology and anal biopsy in men who have sex with men (MSM) who are HIV carriers and anal intraepithelial neoplasia (AIN) associated with human papillomavirus (HPV). Materials and methods: cross-sectional observational study from December 2011 to December 2013 to determine the matching of the results of cytology and anal biopsy in men who have sex with men (MSM) who are HIV carriers and AIN associated with HPV in patients with Infectious Diseases at the La Raza National Medical Center. Descriptive statistical analysis was performed. Results: 92 HIV positive and HPV positive subjects were studied, the final histopathological report of anal biopsies were: low-grade intraepithelial neoplasia in 39%, high-grade intraepithelial neoplasia 4%, atypical cells of undetermined significance 3%, normal in 27, with reactive inflammatory changes in 23% and inadequate samples for diagnosis 9%. The matching observed between both diagnostic methods was 0.90 based on Cronbach's alpha. Conclusion: the matching degree of 90% of the anal Pap smears and biopsies indicates that they are good monitoring methods of patients infected with HIV and HPV, and can detect precancerous lesions in a timely manner, providing prompt diagnosis and treatment.KEYWORDS: neoplasms, carcinoma in situ, Papillomavirus infections, HIV, sexual behavior.Resumo Objetivo: determinar a concordância dos resultados do exame citológico e a biópsia anal em homens que fazem sexo com homens (HSH) portadores de HIV e neoplasia intraepitelia...

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“…14 Diseases associated with HPV are even more frequent in HIV positive MSM population. 10,12,15 In Canada and in the province of Quebec, the percentage of MSM is estimated to be about 5%. [16][17][18] Among those living in Quebec, 18.3% have had anogenital warts sometime in their lives.…”

Section: Epidemiology and Clinical Burden Of Hpv Among Msmmentioning

confidence: 99%

HPV Vaccination for MSM: Synthesis of the evidence and recommendations from the Québec Immunization Committee

Sauvageau

Dufour-Turbis

2015

Human Vaccines & Immunotherapeutics

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Diseases associated with the human papilloma virus (HPV) are particularly common among men who have sex with men (MSM). Unlike heterosexual men, MSM do not benefit from the herd protection provided by the vaccination of girls. In this review, we synthesize the available evidence on HPV vaccination for MSM. We also present the recommendations of the Quebec Immunization Committee (CIQ) in this regard, which are: to provide targeted vaccination for MSM up to 26 years of age and in-school vaccination of preadolescent boys since this is the best approach to take to have a real impact on the burden related to HPV in the MSM population and to provide direct protection for all men.

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Incidence and Epidemiology of Anal Cancer in the Multicenter AIDS Cohort Study

Cited by 300 publications

References 51 publications

Anal cancer and cervical cancer screening: Key differences

Anal cancer and cervical cancer screening: Key differences

Concordancia histopatológica entre la citología y la biopsia anal en hombres que tienen sexo con hombres portadores de VIH y neoplasia intraepitelial anal asociada a VPH

HPV Vaccination for MSM: Synthesis of the evidence and recommendations from the Québec Immunization Committee

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