Incidence and distribution of various connective tissue fibers in oral fibromas

Oles, R.D.

doi:10.1016/0030-4220(68)90329-0

Cited by 5 publications

(7 citation statements)

References 18 publications

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“…This was a remarkable finding, when values for this lesion were higher than IH (Tables 1 and 3). These results are in accordance with previous studies (Oles et al, 1968;Regezi et al, 1975). These data were reinforced by the confocal laser scanning microscopy analysis that also showed that the density of the collagenous fibers was higher in OF than in IH, probable due to a different collagen fiber type or different rate of biosynthesis.…”

Section: Discussionsupporting

confidence: 92%

“…The OF and IH are lesions that superimpose clinical and microscopical characteristics. Although the literature is controversial in relation to the etiology of oral fibroma, we assume, based on the literature (Oles et al, 1968;Magnusson;Rasmusson, 1995;Regezi;Courtney;Kerr, 1975;Provenzano et al, 2006;Hirschberg;Dayan, 1996) that these lesions are neoplastic in nature. In order to depict their histopathological characteristics, quantitative and qualitative analysis were performed.…”

Section: Discussionmentioning

confidence: 99%

“…The normal extracellular matrix of the oral tissues and the connective tissue of the OF and IH are mainly formed by collagen fibers and elastic system fibers (Oles et al, 1968;Gogly et al, 1997;Ushiki, 2002). Their clinical and histological similarities have caused some controversies in the literature, leading to the use of different terminology to refer to these entities.…”

Section: Introductionmentioning

confidence: 99%

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Differential diagnosis between oral fibroma and inflammatory hyperplasia: a proposal for histopathological criteria

Badauy

Carrard

Nóbrega

et al. 2013

R. Fac. Odontol. Porto Alegre

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Aim:The present study proposed histopathological criteria for the differential diagnosis between those pathological entities. Materials and methods: Histological sections of lesions histopathologically diagnosed as Oral Fibroma (n=61) and Inflammatory Hyperplasia (n=75) and were submitted to different techniques (Hematoxylin-Eosin; Masson Trichrome and Phosphomolybdic acid -Picrosirius red) to allow quantitative and qualitative analysis. The qualitative analysis of collagen density was based on sections stained by Hematoxylin-Eosin and focused in the center and periphery of each lesion. Results: Wound and collagen fibers were more frequent and higher in Oral Fibroma, while parallel fibers were more frequent in Inflammatory Hyperplasia (Fisher's exact test, p<0.05). The percentage of parallel collagen fibers beneath the epithelium was 72.22% and 92.3% in Oral Fibroma and Inflammatory Hyperplasia, respectively (Mann Whitney U test, p<0.05). The parallel collagen fibers in the center of the lesion was found in 84.6% of Inflammatory Hyperplasia cases and was absent in 88.88% of Oral Fibroma. The central portion of Oral Fibroma had characteristically a dense and wound arrangement of collagen fibers. Conclusion: Oral Fibroma and Inflammatory Hyperplasia have distinctive features that may be useful in routine histopathological analysis, supporting the differential diagnosis.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Differential diagnosis between oral fibroma and inflammatory hyperplasia: a proposal for histopathological criteria

Badauy

Carrard

Nóbrega

et al. 2013

R. Fac. Odontol. Porto Alegre

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“…Previous reports have described elastic system fibres in fibrous oral mucosal lesions (29)(30)(31)(32), However, none ofthese reports was able to identify elastin positively and some of the terminology was confusing, so direct comparison with this study is difficult. For example, OLES (29) identified elastic system fibres in seventeen of twenty-five 'oral fibromas' that originated from buccal, lingual, gingival and dentoalveolar ridge mueosa.…”

Section: Discussionmentioning

confidence: 68%

Histochemical and immunohistochemical localisation of elastic system fibres in focal reactive overgrowths of oral mucosa

Mighell

Robinson

Hume

1997

J Oral Pathology Medicine

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Eight specimens each of the following groups were investigated: gingival pyogenic granuloma, fibrous epulis, calcifying fibrous epulis, peripheral giant cell granuloma, giant cell fibroma (four gingival, four non-gingival), denture-irritation hyperplasia and fibroepithelial polyp. These lesions have diverse histopathological appearances but the composition of their connective tissue is poorly defined. The elastic system consists of a complex mixture of glycoproteins that in normal oral mucosa form three differentially distributed fibre types; oxytalan, elaunin and elastic. The elastic system was investigated by Verhoeff's haematoxylin stain, aldehyde fuchsin staining and an anti-elastin monoclonal antibody. Elastin was identified in all fibroepithelial polyps and denture-irritation hyperplasias, but in none of the other lesions. In particular, this identified a distinct difference in the extracellular matrix between the giant cell fibroma and fibroepithelial polyp. Many of the epulides included only oxytalan fibres, but the presence of oxytalan fibres did not follow any pattern within either a single lesion group, or between different lesions. However, the presence of oxytalan fibres in the absence of elastin does not necessarily support a periodontal ligament origin for reactive epulides.

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“…Oxytalan fibers also occur in odontogenic fibromas (22). peripheral fibromas (23), and in most benign fibro-osseous lesions of the jaws, if mature collagen is present (24). Clearly, oxytalan fibers are not unique to oral tissues (25); nevertheless, their increased number in peripheral fibromas suggests that the lesion originates from cells eapable of producing sueh fibers, i.e., from fibioblasts of the gingivae or periodontal membrane.…”

Section: Discussionmentioning

confidence: 99%

Chondrogenesis in peripheral fibromas of the gingiva. Histochemical demonstration of oxytalan fibers and mucopolysaccharides

Balogh

Richardson

1986

J Oral Pathology Medicine

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Five lesions were studied to elucidate the histogenesis of cartilage in peripheral fibromas. Cytological features suggested direct transformation from fibroblast‐like cells to chondrocyles (cartilaginous metaplasia). Supportive evidence for such differentiation was the presence of neutral and acid mucopolysaccharides in the loose stroma of the lesions as well as in the ground substance of the cartilaginous centers. In one instance, the metaplastic cartilage showed bone formation. An increased number of oxytalan fibers could be demonstrated in the fibroma and in the cartilage.

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Incidence and distribution of various connective tissue fibers in oral fibromas

Cited by 5 publications

References 18 publications

Differential diagnosis between oral fibroma and inflammatory hyperplasia: a proposal for histopathological criteria

Differential diagnosis between oral fibroma and inflammatory hyperplasia: a proposal for histopathological criteria

Histochemical and immunohistochemical localisation of elastic system fibres in focal reactive overgrowths of oral mucosa

Chondrogenesis in peripheral fibromas of the gingiva. Histochemical demonstration of oxytalan fibers and mucopolysaccharides

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