Incidence and Direct Medical Costs of Hospitalizations due to Osteoporotic Fractures in Switzerland

Lippuner, Kurt; Overbeck, Jan von; Perrelet, Romain; Bosshard, H; Jaeger, Philippe

doi:10.1007/pl00004149

Cited by 132 publications

(79 citation statements)

References 24 publications

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“…Before making their hypothetical decisions in the DCE, respondents were informed about their risk of breaking the femur as well as the resulting risk of death. Mortality rates given fracture of the femur were used according to age class to estimate the implied relative reduction in mortality due to this particular cause (Hubacher and Ewert, 1997;Lippuner et al, 1997). The associated marginal WTP values were then integrated for a protective effect of 100 percent which allowed the computation of the value of a statistical life, amounting to 1.9 mn.…”

Section: Convergent Validity: Value Of a Statistical Lifementioning

confidence: 99%

Validity of discrete-choice experiments evidence for health risk reduction

Telser

Zweifel

2007

Applied Economics

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Standard-Nutzungsbedingungen:Die Dokumente auf EconStor dürfen zu eigenen wissenschaftlichen Zwecken und zum Privatgebrauch gespeichert und kopiert werden.Sie dürfen die Dokumente nicht für öffentliche oder kommerzielle Zwecke vervielfältigen, öffentlich ausstellen, öffentlich zugänglich machen, vertreiben oder anderweitig nutzen.Sofern die Verfasser die Dokumente unter Open-Content-Lizenzen (insbesondere CC-Lizenzen) zur Verfügung gestellt haben sollten, gelten abweichend von diesen Nutzungsbedingungen die in der dort genannten Lizenz gewährten Nutzungsrechte. Terms of use: Documents in

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Section: Convergent Validity: Value Of a Statistical Lifementioning

confidence: 99%

Validity of discrete-choice experiments evidence for health risk reduction

Telser

Zweifel

2007

Applied Economics

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“…Patients with lytic bone diseases are at a higher risk of sustaining fractures. Therefore, lytic bone diseases are an increasingly serious social and economic issue, due to the high medical costs associated with hospitalization (4). Therefore, inhibiting osteoclast formation may represent a treatment option for disease involving excessive bone resorption (5).…”

Section: Introductionmentioning

confidence: 99%

Amiloride inhibits osteoclastogenesis by suppressing nuclear factor-κB and mitogen-activated protein kinase activity in receptor activator of nuclear factor-κB-induced RAW264.7 cells

Wang

Zhu

Zheng

et al. 2015

Molecular Medicine Reports

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Abstract.Amiloride is widely used in clinical practice as a diuretic and is known to interact with the epithelial sodium channel and acid-sensing ion channel proteins, as well as Na + /H + antiporters and Na + /Ca 2+ exchangers. The aim of the present study was to examine the effects of amiloride on receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis and to elucidate the underlying mechanisms in the RAW264.7 murine macrophage cell line. The number of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells were counted and the bone resorption area was estimated. In addition the expression levels of nuclear factor of activated T cells, cytoplasmic 1 (NFATc1) mRNA and osteoclast-specific genes, including TRAP, matrix metalloproteinase 9, cathepsin K and osteoclast-associated receptor, were examined using reverse transcription-quantitative polymerase chain reaction. The nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways were also investigated using western blotting. The results showed that amiloride significantly reduced the number of TRAP-positive multinucleated cells as well as the bone resorption area. Amiloride also downregulated the expression of NFATc1 mRNA and inhibited the expression of osteoclast-specific genes. A possible underlying mechanism may be that amiloride suppresses the degradation of the inhibitor of NF-κB and blocks the activation of c-Jun N-terminal kinase, extracellular signal-regulated kinase and p38, thus implicating the NF-κB and MAPK pathway is this process. In conclusion, the current data suggest that amiloride is a strong inhibitor of osteoclast differentiation, indicating a novel indication for amiloride in the treatment of bone-loss-related diseases.

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“…In terms of duration of hospital stay, the annual cost of hospitalisations for osteoporotic fractures is higher than those for myocardial infarction, stroke and breast cancer (10) . In 2000 62 535 hospitalisations for fractures were registered.…”

Section: Epidemiologymentioning

confidence: 98%

Postgraduate Symposium Positive influence of nutritional alkalinity on bone health

et al. 2009

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There is growing evidence that consumption of a Western diet is a risk factor for osteoporosis through excess acid supply, while fruits and vegetables balance the excess acidity, mostly by providing K-rich bicarbonate-rich foods. Western diets consumed by adults generate approximately 50-100 mEq acid/d; therefore, healthy adults consuming such a diet are at risk of chronic low-grade metabolic acidosis, which worsens with age as a result of declining kidney function. Bone buffers the excess acid by delivering cations and it is considered that with time an overstimulation of this process will lead to the dissolution of the bone mineral content and hence to reduced bone mass. Intakes of K, Mg and fruit and vegetables have been associated with a higher alkaline status and a subsequent beneficial effect on bone health. In healthy male volunteers an acid-forming diet increases urinary Ca excretion by 74 % and urinary C-terminal telopeptide of type I collagen (C-telopeptide) excretion by 19 % when compared with an alkali (base-forming) diet. Cross-sectional studies have shown that there is a correlation between the nutritional acid load and bone health measured by bone ultrasound or dual-energy X-ray absorptiometry. Few studies have been undertaken in very elderly women ( > 75 years), whose osteoporosis risk is very pertinent. The EVAluation of Nutrients Intakes and Bone Ultra Sound Study has developed and validated (n 51) an FFQ for use in a very elderly Swiss population (mean age 80 . 4 (SD 2 . 99) years), which has shown intakes of key nutrients (energy, fat, carbohydrate, Ca, Mg, vitamin C, D and E) to be low in 401 subjects. A subsequent study to assess net endogenous acid production (NEAP) and bone ultrasound results in 256 women aged ‡ 75 years has shown that lower NEAP (P = 0 . 023) and higher K intake (P = 0 . 033) are correlated with higher bone ultrasound results. High acid load may be an important additional risk factor that may be particularly relevant in very elderly patients with an already-high fracture risk. The latter study adds to knowledge by confirming a positive link between dietary alkalinity and bone health indices in the very elderly. In a further study to complement these findings it has also been shown in a group of thirty young women that in Ca sufficiency an acid Ca-rich water has no effect on bone resorption, while an alkaline bicarbonate-rich water leads to a decrease in both serum parathyroid hormone and serum C-telopeptide. Further investigations need to be undertaken to study whether these positive effects on bone loss are maintained over long-term treatment. Mineral-water consumption could be an easy and inexpensive way of helping to prevent osteoporosis and could be of major interest for long-term prevention of bone loss.Dietary alkalinity: Bone health: Acid-base balance: Elderly Osteoporosis is a skeletal disorder characterised by low bone mass and microarchitectural deterioration of bone tissue, leading to bone fragility and an increased risk of fracture. Optimum bone health is ach...

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Incidence and Direct Medical Costs of Hospitalizations due to Osteoporotic Fractures in Switzerland

Cited by 132 publications

References 24 publications

Validity of discrete-choice experiments evidence for health risk reduction

Validity of discrete-choice experiments evidence for health risk reduction

Amiloride inhibits osteoclastogenesis by suppressing nuclear factor-κB and mitogen-activated protein kinase activity in receptor activator of nuclear factor-κB-induced RAW264.7 cells

Postgraduate Symposium Positive influence of nutritional alkalinity on bone health

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