Incidence and Demographics of Pediatric Intracranial Hypertension

Gillson, Natalie; Jones, Charlotte; Reem, Rachel E.; Rogers, David L.; Zumberge, Nicholas; Aylward, Shawn C.

doi:10.1016/j.pediatrneurol.2017.04.021

Cited by 54 publications

(35 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The absence of Asian/Pacific Islanders and Hispanics-racial/ethnic groups with the smallest incidences in our dataset-likely contributed to the larger peak incidence in Olmsted County (21). Meanwhile, in central Ohio (2010-2013), a study on pediatric (0-18 years old) patients found an incidence of 0.63 (47).…”

Section: Agementioning

confidence: 74%

Idiopathic Intracranial Hypertension in the United States: Demographic and Socioeconomic Disparities

Ghaffari-Rafi

Mehdizadeh

et al. 2020

Front. Neurol.

View full text Add to dashboard Cite

Background: Obesity's risk increases for low-income, female, young, and Black patients. By extrapolation, idiopathic intracranial hypertension (IIH)-a disease associated with body mass index-would potentially display socioeconomic and demographic disparities. Methods: IIH incidence (per 100,000) was investigated with respect to sex, age, income, residence, and race/ethnicity, by querying the largest United States (US) healthcare administrative dataset (1997-2016), the National (Nationwide) Inpatient Sample. Results: Annual national incidence (with 25th and 75th quartiles) for IIH was 1.15 (0.91, 1.44). Females had an incidence of 1.97 (1.48, 2.48), larger (p = 0.0000038) than males at 0.36 (0.26, 0.38). Regarding age, largest incidence was among those 18-44 years old at 2.47 (1.84, 2.73). Low-income patients had an incidence of 1.56 (1.47, 1.82), larger (p = 0.00024) than the 1.21 (1.01, 1.36) of the middle/high. No differences (χ 2 = 4.67, p = 0.097) were appreciated between urban (1.44; 1.40, 1.61), suburban (1.30; 1.09, 1.40), or rural (1.46; 1.40, 1.48) communities. For race/ethnicity (χ 2 = 57, p = 2.57 × 10 −12), incidence was largest for Blacks (2.05; 1.76, 2.74), followed by Whites (1.04; 0.79, 1.41), Hispanics (0.67; 0.57, 0.94), and Asian/Pacific Islanders (0.16; 0.11, 0.19). Year-to-year, incidence rose for all strata subsets except Asian/Pacific Islanders (τ = −0.84, p = 0.00000068). Conclusion: IIH demonstrates several sociodemographic disparities. Specifically, incidences are larger for those low-income, Black, 18-44 years old, or female, while annually increasing for all subsets, except Asian/Pacific Islanders. Hence, IIH differentially afflicts the US population, yielding in healthcare inequalities.

show abstract

Section: Agementioning

confidence: 74%

Idiopathic Intracranial Hypertension in the United States: Demographic and Socioeconomic Disparities

Ghaffari-Rafi

Mehdizadeh

et al. 2020

Front. Neurol.

View full text Add to dashboard Cite

show abstract

“…The typical adult patient with PTCS is an obese female of child-bearing age [3,6,9]. Conversely, in young children, there is an equal distribution between males and females [10,11].…”

Section: Epidemiology and Demographicsmentioning

confidence: 99%

Pseudotumor Cerebri Syndrome in Children

Barmherzig

Szperka

2019

Curr Pain Headache Rep

View full text Add to dashboard Cite

Pupose of Review: Pseudotumor cerebri syndrome (PTCS) may affect both children and adults, however the risk factors and clinical presentation vary greatly between these populations. This review aims to highlight the entity of PTCS in children and the unique considerations in this population; review the epidemiology and demographics; discuss the clinical presentation, revised diagnostic criteria, and approach to evaluation; review management strategies; and discuss the prognosis and long-term outcomes in children with PTCS. Recent Findings: Clinical presentation can be variable in children and may be less obvious than in their adult counterparts. Papilledema can also be challenging to diagnose in this population. The upper limits for opening pressure on lumbar puncture differ in children, with a cutoff of 25 cm H20 (or 28 cm H2O in a sedated or obese child). Summary: Morbidity related to visual loss, pain, and reduced quality of life lends urgency towards accurately identifying, evaluating, and managing children with PTCS. There are no randomised controlled studies to allow for evidence-based recommendations for the management of PTCS in children. Further studies are needed to clarify and consolidate management approaches in this population.

show abstract

“…4 In children age <18 years, the incidence is comparable but slightly less, at 0.63 to 0.90 in 100,000. 2,5 In adults with IIH, there is a strong predilection for female gender and obesity, but in children, this association varies based on the pubertal status of the child. While pubertal children have a strong female predominance that is similar to adults, in prepubertal children, boys and girls are likely to be affected similarly.…”

Section: Epidemiologymentioning

confidence: 99%

“…Pseudotumor cerebri syndrome is a term that is currently proposed to describe the condition of elevated intracranial pressure without the presence of a mass. This new terminology encompasses idiopathic intracranial hypertension (IIH), the most common cause of pseudotumor cerebri syndrome in adults and children, [1][2][3] as well as secondary causes of elevated intracranial pressure, including exposure to certain medications, abnormalities of the cerebral venous system, or predisposing systemic diseases. 1 This review focuses on pediatric IIH and will examine the most recent and reliable data regarding the epidemiology, pathophysiology, risk factors, diagnostic testing, treatment, and outcomes, considering the differences from the adult condition.…”

mentioning

confidence: 99%

Pediatric Idiopathic Intracranial Hypertension

Gaier

Heidary

2019

Semin Neurol

View full text Add to dashboard Cite

The presentation of idiopathic intracranial hypertension (IIH) in pediatric populations has several important distinctions from that in adults, especially among prepubertal patients, in which there is no apparent association with gender or obesity. Pediatric patients are more likely to be asymptomatic or present with atypical symptoms than their adult counterparts, posing a diagnostic challenge in some cases. It is important to be aware of the ways in which diagnostic criteria for IIH are modified from that of adults. Ideal treatment practices and the natural history of pediatric IIH remain unclear. Acetazolamide is the mainstay of medical treatment, but some patients with significant visual loss may require surgical intervention. Multicenter studies to accrue a large number of cases and future prospective studies will help to better define pediatric IIH and to formulate consensus guidelines for treatment and management of these patients.

show abstract

Incidence and Demographics of Pediatric Intracranial Hypertension

Cited by 54 publications

References 25 publications

Idiopathic Intracranial Hypertension in the United States: Demographic and Socioeconomic Disparities

Idiopathic Intracranial Hypertension in the United States: Demographic and Socioeconomic Disparities

Pseudotumor Cerebri Syndrome in Children

Pediatric Idiopathic Intracranial Hypertension

Contact Info

Product

Resources

About