Incidence and Clinical Phenotype of Multisystem Inflammatory Syndrome in Children After Two SARS-CoV-2 Pandemic Waves: A Croatian Prospective Nationwide Study

Marić, Lorna Stemberger; Trkulja, Vladimir; Petrović, Davor; Tomulić, Kristina Lah; Bartulović, Ines; Tešović, Goran

doi:10.1097/inf.0000000000003924

Cited by 1 publication

(2 citation statements)

References 9 publications

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“…The variations inherent in such illnesses have become more apparent; therefore, several clinical definitions have emerged. Overall, it is suggested that very few SARS-CoV-2-infected children suffer from MIS-C [ 59 , 78 , 79 ]. Among all pediatric MIS-C in 2 of the latter studies, some 1.7%–2.6% were <1 year of age.…”

Section: Covid-19 Among Infantsmentioning

confidence: 99%

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COVID-19 among infants: key clinical features and remaining controversies

Cimolai

2024

Clin Exp Pediatr

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Infants aged <1 year represent a seemingly more susceptible pediatric subset for infections. Despite this, coronavirus disease 2019 (COVID-19) infection has not been proven as more serious in this age group (outside the very early neonatal period) than in others. Indeed, a considerable number of asymptomatic infections have been recorded, and the symptoms and morbidity associated with COVID- 19 differ minimally from those of other respiratory viral infections. Whether due to an abundance of caution or truly reduced susceptibility, infections in infants have not raised the same profile as those in other age groups. In addition to direct severe acute respiratory syndrome coronavirus 2 diagnostic tests, laboratory markers that differentiate COVID-19 from other viral infections lack specificity in infants. Gastrointestinal presentations are common, and the neurological complications of infection mirror those of other respiratory viral infections. There have been relatively few reports of infant deaths. Under appropriate precautions, breastfeeding in the context of maternal infections has been associated with tangible but infrequent complications. Vaccination during pregnancy provides protection against infection in infants, at least in the early months of life. Multi-inflammatory syndrome in children and multi-inflammatory syndrome in neonates are commonly cited as variants of COVID-19; however, their clinical definitions remain controversial. Similarly, reliable definitions of long COVID in the infant group are controversial. This narrative review examines the key clinical and laboratory features of COVID-19 in infants and identifies several areas of science awaiting further clarification.

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Section: Covid-19 Among Infantsmentioning

confidence: 99%

“…The similarities to Kawasaki disease and toxic shock syndrome continue to be explored, and rightfully so [ 155 ]. Some data suggest the possible difference in MIS-C incidence depending on the SARS-CoV-2 strain dominance [ 79 ].…”

Section: Controversy Regarding Infantsmentioning

confidence: 99%

COVID-19 among infants: key clinical features and remaining controversies

Cimolai

2024

Clin Exp Pediatr

View full text Add to dashboard Cite

show abstract

Incidence and Clinical Phenotype of Multisystem Inflammatory Syndrome in Children After Two SARS-CoV-2 Pandemic Waves: A Croatian Prospective Nationwide Study

Cited by 1 publication

References 9 publications

COVID-19 among infants: key clinical features and remaining controversies

COVID-19 among infants: key clinical features and remaining controversies

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