Incidence and clinical patterns of polypoidal choroidal vasculopathy in Korean patients

Byeon, Suk Ho; Lee, Sung Chul; Oh, Hyun Sub; Kim, Sung Soo; Koh, Hyoung Jun; Kwon, Oh Woong

doi:10.1007/s10384-007-0498-2

Cited by 140 publications

(96 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our findings are in accordance with some studies involving Asian patients with PCV that also show a predominance of unilateral lesions [8,19,28,40]. Nevertheless, reports by Yannuzzi et al [23] (in American patients) and Ladas et al [26] (in Greek patients) show a predominance of bilateral lesions.…”

Section: Discussionsupporting

confidence: 73%

“…Table 4 summarizes the percentages of PCV cases in several studies. The proportion of PCV in Asian patients is higher than in American and European patients with neovascular AMD [8,19,23,24,25,26,27,28]. The results of the current study show that the percentage of PCV (22.2% of patients) is similar to percentages in some reports [9,28,29] in Asian populations, but lower than the percentage reported by Maruko et al [8] and Coscas et al [24] in the Japanese population.…”

Section: Discussionmentioning

confidence: 99%

“…Despite these considerations, differences in the prevalence and features of AMD by race and geographic area have been observed [18]. For example, studies have reported that the proportion of disease subtypes among patients with neovascular AMD differs between Asian and Caucasian patients [8,19]. …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Characteristics of Neovascular Age-Related Macular Degeneration in Brazilian Patients

et al. 2015

View full text Add to dashboard Cite

Purpose: To report features of neovascular age-related macular degeneration (AMD) in Brazilian patients. Procedures: Data were prospectively collected from patients diagnosed with neovascular AMD. Eyes were classified as having typical neovascular AMD, polypoidal choroidal vasculopathy (PCV), or retinal angiomatous proliferation (RAP). Results: In total, 265 eyes of 207 patients of predominantly Caucasian ancestry were included; 166 (62.6%) eyes had typical neovascular AMD, 65 (24.5%) eyes had PCV, and 34 (12.8%) eyes had RAP. RAP demonstrated a higher percentage of bilateral cases (p = 0.015). The mean foveal subfield thickness was significantly lower in eyes with PCV (p < 0.001). Cases with typical neovascular AMD had a higher percentage of predominantly classic and minimally classic lesions on fluorescein angiography (FA; p = 0.005). Conclusions: In Brazilian patients, PCV and RAP represented 24.5 and 12.8% of neovascular AMD cases. Neovascular AMD subtypes differ in relation to clinical features, mean foveal subfield thickness and FA presentation.

show abstract

Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Characteristics of Neovascular Age-Related Macular Degeneration in Brazilian Patients

et al. 2015

View full text Add to dashboard Cite

show abstract

“…PCV is more prevalent in Asian and African-American populations than Caucasians, which may cause the heterogeneity in the clinical features of AMD among the races. Previous studies reported that PCV accounts for 23.0-54.7% of patients with neovascular AMD in the Japanese [11,20,30], 49% in the Taiwanese [31], 22.3-24.5% in the Chinese [32,33] and 22.2-24.6% in the Korean populations [34,35], but in only about 8-13% of Caucasians [36]. African-Americans are also known to be susceptible to PCV, although no epidemiological study for black people has been reported to date.…”

Section: Epidemiologymentioning

confidence: 99%

Polypoidal Choroidal Vasculopathy: Clinical Features and Genetic Predisposition

2013

View full text Add to dashboard Cite

Polypoidal choroidal vasculopathy (PCV) is currently recognized as a phenotype of age-related macular degeneration (AMD). PCV is believed to be a type of choroidal neovascularization, although some cases of PCV show a distinct vascular abnormality of the choroidal vessels. PCV often shows several unique clinical manifestations which are apparently different from typical neovascular AMD (tAMD). In addition, the natural course and response to treatment are often different between tAMD and PCV. Moreover, recent genetic studies suggested a possible difference in the genetic susceptibility to disease between tAMD and PCV, as well as the existence of heterogeneity among PCV cases. In viewing the accumulation of knowledge about PCV, we have summarized the recent literature regarding PCV in this review article to improve the understanding of this clinical entity including possible susceptibility genes. We will also discuss the optimal treatment strategies for PCV in accordance with the results of recent clinical and genetic studies.

show abstract

“…2,3 PCV is highly prevalent in Asian patients with age-related macular degeneration (AMD) and also develops in Caucasian patients. [4][5][6][7][8] Treatment with photodynamic therapy (PDT) with verteporfin (Visudyne, Novartis Pharma AG, Basel, Switzerland) can occlude the polypoidal lesions in patients with PCV. 9,10 However, the branching vascular network can remain after PDT.…”

Section: Introductionmentioning

confidence: 99%

Two-year results of intravitreal ranibizumab for polypoidal choroidal vasculopathy with recurrent or residual exudation

Saito

Iida

Kano

et al. 2013

Eye

View full text Add to dashboard Cite

Aim To clarify the 2-year efficacy of ranibizumab for patients with polypoidal choroidal vasculopathy (PCV) with recurrent or residual exudation from branching vascular networks after previous photodynamic therapy (PDT). Methods We retrospectively reviewed 26 eyes of 26 Japanese patients (22 men, 4 women) in this pilot study. All eyes had PCV with complete regression of polypoidal lesions resulting from PDT detected by indocyanine green angiography (ICGA), but recurrent or residual leakage from branching vascular networks on fluorescein angiography and evidence of persistent fluid on optical coherence tomography (OCT). Three consecutive intravitreal injections of ranibizumab (0.5 mg/0.05 ml) were administered to all eyes. Results The mean logarithm of the minimum angle of resolution best-corrected visual acuity (BCVA) improved significantly from 0.55 at baseline to 0.35 at 12 months (Po0.0001) and 0.43 at 24 months (P ¼ 0.0012). The mean increases in the BCVA 12 and 24 months after baseline were 1.95 and 1.23 lines, respectively. The mean central retinal thickness significantly decreased from 295 mm at baseline to 189 mm at 12 months (Po0.0038) and 163 mm at 24 months (Po0.001). The mean numbers of intravitreal ranibizumab (IVR) injections at months 12 and 24, including the initial treatments, were 5.8 and 8.8, respectively. Five (19.2%) eyes had recurrent polypoidal lesions on ICGA at a mean of 15.7 months after baseline. At month 24, OCT showed no exudation in 17 (65.4%) of the 26 eyes. No adverse events developed.Conclusions IVR injections maintained or improved the VA and retinal thickness at 24 months in eyes with PCV with recurrent or residual exudation from branching vascular networks after previous PDT.

show abstract

Incidence and clinical patterns of polypoidal choroidal vasculopathy in Korean patients

Abstract: The incidence of PCV in Korean exudative AMD patients was relatively high compared with that in other ethnic groups. As in other Asian patient populations, PCV occurred more commonly in men and was predominantly unilateral.

Cited by 140 publications

References 35 publications

Characteristics of Neovascular Age-Related Macular Degeneration in Brazilian Patients

Characteristics of Neovascular Age-Related Macular Degeneration in Brazilian Patients

Polypoidal Choroidal Vasculopathy: Clinical Features and Genetic Predisposition

Two-year results of intravitreal ranibizumab for polypoidal choroidal vasculopathy with recurrent or residual exudation

Contact Info

Product

Resources

About