Incidence and Clinical Characteristics of Patients Presenting With Myocardial Infarction With Non-Obstructive Coronary Arteries (MINOCA)

Amdouni, Nesrine; Chamtouri, Ikram; Abdallah, Asma Ben; Abbes, Chahrazed; Abdallah, Wajih; Jomaa, Walid; Hamda, Khaldoun Ben; Maatouk, Faouzi

doi:10.1016/j.carrev.2022.06.068

Cited by 2 publications

(1 citation statement)

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“…It is a prevalent symptom of myocardial ischemia, highlighting the need for prompt, accurate diagnosis. While the conventional approach to diagnosing this condition involves coronary angiography to detect coronary artery stenosis, there is a tendency to overlook non-obstructive coronary artery disease and disregard the potential presence of coronary microvascular dysfunction (CMD) 2, 3 . This oversight presents an ongoing challenge in clinical practice, hampering effective management and treatment strategies.…”

Section: Introductionmentioning

confidence: 99%

From Chest Pain to Coronary Functional Testing: Clinical and Economic Impact of Coronary Microvascular Dysfunction

Merdler,

Wallace,

Hill

et al. 2024

Preprint

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Background: Coronary functional testing to formally diagnose coronary microvascular dysfunction (CMD) reduces cardiovascular events and alleviates angina. This study aims to investigate the extensive and complex journey that patients with CMD undergo, from the onset of chest pain to eventual diagnosis. Methods: Data from the Coronary Microvascular Disease Registry (CMDR) were analyzed, including information on the date of first documentation of chest pain, number of non-invasive and invasive tests the patient underwent, emergency department visits, and hospitalizations. In addition, we estimated the total cost per patient. A total of 61 patients with CMD diagnosis were included in this analysis. Results: The cohort had an average age of 65.6±9.9 years. The median time from initial chest pain symptoms to diagnosis was 0.62 (interquartile range [IQR]: 0.06-2.96) years. During this period, patients visited the emergency department a median of 1.0 (IQR: 0.0-2.0) times. Diagnostic tests included 3.0 (IQR: 2.0-6.0) electrocardiograms, 3.0 (IQR: 0.0-6.0) high-sensitivity troponin tests, and 1.0 (IQR: 1.0-2.0) echocardiograms. Prior to diagnosis of CMD, 13 (21.3%) patients had left heart catheterization without coronary functional testing. Non-invasive testing for ischemia was conducted in 43 (70.5%) patients. Alternative non-cardiac diagnoses were given to 11 (18.0%) patients during the diagnostic process, with referrals made to gastroenterology for 16 (26.2%) and pulmonology for 10 (16.4%) patients. The cost averaged $1,790±2,506 per patient. Conclusion: Timely identification of CMD offers promising opportunities for prompt symptom alleviation, accompanied by reduced visits to the emergency department, cardiovascular testing, invasive medical procedures, and consequently reduced healthcare expenses.

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Section: Introductionmentioning

confidence: 99%