Incidence and characterization of secondary myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemoradiotherapy and autologous stem-cell transplantation for lymphoid malignancies.

Darrington, Deborah L.; Vose, Julie M.; Anderson, James R.; Bierman, Philip J.; Bishop, Michael; Chan, Wing C.; Morris, Mary E.; Reed, Eddie; Sanger, WG; Tarantolo, Stefano

doi:10.1200/jco.1994.12.12.2527

Cited by 306 publications

(160 citation statements)

References 34 publications

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“…2,3 However, there are concerns about both late relapses and the development of secondary leukaemia following auto-SCT. [2][3][4][5] Myeloablative therapy and allo-SCT has been employed in patients with advanced FL and is capable of inducing lasting remissions and cure even in patients with advanced disease. [6][7][8] However, this therapeutic modality has been limited in its application due to the high TRM and is generally reserved for younger patients.…”

Section: Introductionmentioning

confidence: 99%

The outcome of reduced intensity allogeneic stem cell transplantation and autologous stem cell transplantation when performed as a first transplant strategy in relapsed follicular lymphoma: an analysis from the Lymphoma Working Party of the EBMT

Robinson

Canals²,

Luang

et al. 2013

Bone Marrow Transplant

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Both auto-SCT and reduced intensity allo-SCT (RIST) are employed in the treatment of relapsed follicular lymphoma (FL). We have analysed the outcome of these two transplant procedures when used as a first transplant in this setting. We conducted a retrospective comparison of 726 patients who underwent an auto-SCT and 149 who underwent a RIST as a first transplant procedure for relapsed FL as reported to the Lymphoma Working Party of the European Bone Marrow Transplant. The non-relapse mortality (NRM) was significantly worse for patients undergoing a RIST (relative risk (RR) 4.0, Po0.001). The 1-year NRM was 15% for those undergoing a RIST compared with 3% for those undergoing an auto-SCT. Disease relapse or progression were significantly worse for those receiving an auto-SCT (RR 3.1, Po0.001). Patients undergoing a RIST had a 5-year relapse rate of 20% compared with 47% for those undergoing an auto-SCT. The PFS at 5 years was 57% for patients receiving a RIST compared with 48% for those receiving an auto-SCT. There was no significant difference in OS between the two groups. RIST is associated with a higher NRM and lower relapse rate in patients with relapsed FL.

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Section: Introductionmentioning

confidence: 99%

The outcome of reduced intensity allogeneic stem cell transplantation and autologous stem cell transplantation when performed as a first transplant strategy in relapsed follicular lymphoma: an analysis from the Lymphoma Working Party of the EBMT

Robinson

Canals²,

Luang

et al. 2013

Bone Marrow Transplant

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show abstract

“…4 Following auto-SCT, tMDS/tAML has been reported to occur in up to 15% of patients. [6][7][8][9][10] One previous study 5 implicated priming with VP-16 as a significant factor for development of tAML following ASCT. A subsequent report detected no increased risk for tMDS/tAML with VP-16 mobilization in the absence of TBI conditioning.…”

Section: Discussionmentioning

confidence: 99%

Etoposide plus G-CSF priming compared with G-CSF alone in patients with lymphoma improves mobilization without an increased risk of secondary myelodysplasia and leukemia

Mahindra

Bolwell

Rybicki

et al. 2011

Bone Marrow Transplant

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“…Complications can also occur months to years after HDC. Myelodysplasia and/or acute leukemia has been reported in patients after HDC [62].…”

Section: Nonhematologic Toxicitymentioning

confidence: 99%

High‐Dose Chemotherapy with Autologous Stem Cell Rescue for Breast Cancer: Yesterday, Today and Tomorrow

Brockstein

Williams

1996

STEM CELLS

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Incidence and characterization of secondary myelodysplastic syndrome and acute myelogenous leukemia following high-dose chemoradiotherapy and autologous stem-cell transplantation for lymphoid malignancies.

Abstract: There is an increased risk of MDS/AML following ABMT/PSCT for lymphoid malignancies. NHL patients age > or = 40 years at the time of transplant and who received TBI are at greatest risk.

Cited by 306 publications

References 34 publications

The outcome of reduced intensity allogeneic stem cell transplantation and autologous stem cell transplantation when performed as a first transplant strategy in relapsed follicular lymphoma: an analysis from the Lymphoma Working Party of the EBMT

The outcome of reduced intensity allogeneic stem cell transplantation and autologous stem cell transplantation when performed as a first transplant strategy in relapsed follicular lymphoma: an analysis from the Lymphoma Working Party of the EBMT

Etoposide plus G-CSF priming compared with G-CSF alone in patients with lymphoma improves mobilization without an increased risk of secondary myelodysplasia and leukemia

High‐Dose Chemotherapy with Autologous Stem Cell Rescue for Breast Cancer: Yesterday, Today and Tomorrow

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