Incidence and characteristics of patients presenting with acute myocardial infarction and non‐obstructive coronary artery disease

Abstract

CAD patients were more likely to have traditional risk factors of diabetes, hypertension, hypercholesterolemia, previous MI, previous revascularization with percutaneous coronary intervention or coronary artery bypass graft surgery. Patients presenting with MI and NOCAD were found to have several different etiologies on coronary angiography with the most common being Takotsubo cardiomyopathy.

10‐Gingerol alleviates hypoxia/reoxygenation‐induced cardiomyocyte injury through inhibition of the Wnt5a/Frizzled‐2 pathway

“…Cardiovascular disease is a major cause of elevated human mortality, and its incidence is increasing (Aissaoui et al., 2020). Acute myocardial infarction (AMI) is a common cardiovascular disease that endangers human health (Najib et al., 2015). Previous studies have shown that AMI has high morbidity and mortality, and myocardial ischemia/reperfusion injury (MIRI) is an important cause of this condition (Herlitz et al., 2008; Najib et al., 2015).…”

“…Acute myocardial infarction (AMI) is a common cardiovascular disease that endangers human health (Najib et al., 2015). Previous studies have shown that AMI has high morbidity and mortality, and myocardial ischemia/reperfusion injury (MIRI) is an important cause of this condition (Herlitz et al., 2008; Najib et al., 2015). MIRI refers to an irreversible disease in which ischemic myocardial damage is aggravated after revascularization (Yellon & Hausenloy, 1997).…”

Myocardial Infarction with Non-Obstructive Coronary Arteries: Contemporary Diagnostic and Management Approaches

“…Например, в работе S. Pasupathy с соавт. лишь 40% пациентов с ИМбОКА были женщинами [7], хотя в других исследованиях [2,16,17] их доля намного превышала 50%, достигая 82% в работе S. Agewall с соавт. [17].…”

“…Факторы риска сердечно-сосудистых заболеваний у пациентов с ИМбОКА регистрируются реже, чем у других больных ИМ: дислипидемия у 57,2% против 88,8% (p<0,0001), артериальная гипертония у 62,5% против 76,3% (p=0,0017), сахарный диабет у 19,9% против 32,4% (p<0,0001), заболевания периферических сосудов у 4,6% против 11,5% (p=0,0038), инсульт в анамнезе у 1,7% против 11,9% (p<0,001), ИМ в анамнезе у 9,3% против 23,3% (p<0,0001), чрескожное коронарное вмешательство в анамнезе у 6,9% против 23,4% (p<0,0001) и коронарное шунтирование -у 2,3% против 12,9% (p<0,0001) [2,16]. Однако в мета-анализе пациенты с ИМбОКА характеризовались схожей с предыдущим исследованием частотой выявления таких факторов риска сердечно-сосудистых заболеваний, как артериальная гипертония, курение, сахарный диабет, отягощенный семейный анамнез [7], реже выявлялось лишь наличие дислипидемии (21% против 35%; p<0,001).…”

Cardiovascular Screening for the Asymptomatic Patient with Diabetes: More Cons Than Pros

“…It has been shown that endothelium-dependent epicardial coronary artery vasodilation in response to acetylcholine [ 11 ] or physiological stimuli [ 12 ] is impaired in diabetic patients, suggesting that endothelial dysfunction (known to be an independent predictor of cardiovascular events [ 13 ]) occurs before the development of overt atherosclerosis in these persons. Furthermore, nonobstructive coronary atherosclerosis (defined as either <50% luminal narrowing, <20% narrowing, or unimpaired coronary blood flow, depending on the study [ 14 ]) is also frequently associated with both DM [ 15 , 16 ] and vascular dysfunction [ 17 ], thus independently contributing to the increased CVD event risk [ 18 ]. Collectively, the high rates of CVD risk factors and direct biological effects of diabetes on the cardiovascular system place diabetic persons at very increased risk of developing CVD [ 9 ].…”