Incidence and characteristics of HBV reactivation in hematological malignant patients in south Egypt

Elkady, Abeer; Aboulfotuh, Sahar; Ali, Elsayed Mostafa; Sayed, Douaa; Abdel-Aziz, Nashwa; Ali, Amany; Murakami, Shuko; Iijima, Sayuki; Tanaka, Yasuhito

doi:10.3748/wjg.v19.i37.6214

Cited by 22 publications

(23 citation statements)

References 28 publications

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“…Therefore, the possible effects of vaccination against HBV on S gene variant prevalence can be overlooked in this study. Several studies identified HBV reactivation hepatitis from occult HBV infection, confirmed by molecular analysis [15,32]. Lack of complete distinction between patients with resolved HBV infection from those with occult HBV infection who progressed to HBV reactivation is a limitation of this study.…”

Section: Discussionmentioning

confidence: 87%

Clinical characteristics and molecular analysis of hepatitis B virus reactivation in hepatitis B surface antigen-negative patients during or after immunosuppressive or cytotoxic chemotherapy

et al. 2016

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Section: Discussionmentioning

confidence: 87%

Clinical characteristics and molecular analysis of hepatitis B virus reactivation in hepatitis B surface antigen-negative patients during or after immunosuppressive or cytotoxic chemotherapy

et al. 2016

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“…Occult HBV infection was reported in 21% of HCV-infected Egyptian children with hematological disorders and malignancies with liability for reactivation. There is preliminary evidence that immuno-compromised patients are more susceptible to lower infectious doses and are at a higher risk of developing chronic infections [29][30][31][32].…”

Section: Discussionmentioning

confidence: 98%

Occult hepatitis B virus infection among chronic hemodialysis patients in Alexandria, Egypt

Helaly¹,

Ghazzawi²,

Shawky³

et al. 2015

Journal of Infection and Public Health

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The prevalence of end-stage renal disease has increased dramatically in developing countries. Hepatitis B virus (HBV) infection is a global health problem that represents a significant co-morbidity event that has led to outbreaks of hepatitis B. There are inadequate data concerning occult HBV infection among Egyptian chronic hemodialysis patients. This study aimed to detect occult HBV infection among chronic hemodialysis patients in Alexandria, Egypt. A cross-sectional study was performed on 100 patients with end-stage renal disease that received maintenance hemodialysis and had tested negative for HBV surface antigen. Blood samples were collected before the initiation of hemodialysis. Sera were tested for hepatitis C virus (HCV) and hepatitis B core (HBc) antibodies using ELISA, and HBV DNA was detected by SYBR Green real-time PCR using specific primers for the s and c genes and by nested PCR using pol gene-specific primers. The serum activity of alanine and aspartate aminotransferase (ALT and AST) were also measured. Anti-HCV and anti-HBc antibodies were detected in 34% and 48% of patients, respectively, and 70.6% of anti-HCV positive patients were also positive for anti-HBc antibodies. This association was statistically significant (p=0.001). HBV DNA was detected in 32% of the hemodialysis patients. A significant association was determined between the presence of HBV DNA and anti-HCV positivity (p=0.021). Aminotransferases were elevated in 21% of the studied patients, more often in patients with positive anti-HCV profiles than in patients negative for anti-HCV (p<0.05). In conclusion, the serological markers of HBV infection should be verified with molecular tests to investigate possible occult infections, especially among anti-HBc-positive hemodialysis patients, to improve our understanding of their clinical, laboratory, and epidemiological characteristics.

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“…A precore stop mutation (A1896) was detected in one patient with genotype Bj who developed fulminant liver failure [63] . Also sub-genotype D1 has been described as possibly associated with HBV reactivation in two studies, one from Egypt and one from Italy [21,64] . There is general agreement for the use of nucleos(t)ide analogues to prevent HBV reactivation in HBsAgpositive immunosuppressed patients, whereas it is still a matter of debate whether subjects with occult HBV infection should be treated or closely monitored for early treatment once HBsAg positivity has developed.…”

Section: Immunosuppressionmentioning

confidence: 99%

Clinical impact of occult hepatitis B virus infection in immunosuppressed patients

Sagnelli

Pisaturo

Martini

et al. 2014

WJH

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Incidence and characteristics of HBV reactivation in hematological malignant patients in south Egypt

Abstract: Past infection with HBV is a risk factor for HBV reactivation in Egypt. Mandatory anti-HBc screening prior to chemotherapy in patients with hematological malignancies is recommended.

Cited by 22 publications

References 28 publications

Clinical characteristics and molecular analysis of hepatitis B virus reactivation in hepatitis B surface antigen-negative patients during or after immunosuppressive or cytotoxic chemotherapy

Clinical characteristics and molecular analysis of hepatitis B virus reactivation in hepatitis B surface antigen-negative patients during or after immunosuppressive or cytotoxic chemotherapy

Occult hepatitis B virus infection among chronic hemodialysis patients in Alexandria, Egypt

Clinical impact of occult hepatitis B virus infection in immunosuppressed patients

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