Incidence and characterisation of cells expressing IGE in the lamina propria in ulcerative colitis

Payne, Richard F.; Steer, H W

doi:10.1016/s0016-5085(00)81324-4

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, Payne et al [28] observed by immnohistochemical staining that MC counts in colonic lamina propria in active ulcerative colonitis was markedly decreased, while eosionphils increased, MCs degranulation may contribute to decreased MC density. However, esophageal mucosal inflammation in NERD is commonly mild and no active lesion, such as swelling of superficial cells, focal basal cell hyperplasia, hyperaemia and dilation of blood vessels in epidermis papilla [29].…”

Section: Discussionmentioning

confidence: 99%

Alterations of Mast Cells in the Esophageal Mucosa of the Patients With Non-Erosive Reflux Disease

Ding

Wang

et al. 2011

Gastroenterol Res

View full text Add to dashboard Cite

BackgroundMast cells (MCs) are widely distributed in the gastrointestinal tract, which could be involved in visceral hypersensitivity and gut dysmotility. Whether esophageal MCs play a role in non-erosive reflux disease (NERD) has yet to be determined. The aim of this study was to characterize esophageal MCs distribution, degranulation, and ultrastructure.MethodsThe esophageal mucosa at 5 cm above the end of esophagus was obtained from 26 NERD and 14 healthy volunteers (control) by gastroscopy. Immunohistochemistry was performed and average MC counts per high-power field (HPF) and the percentage of degranulated MCs were obtained. The ultrastructure of MCs was observed by transmission electron microscope (TEM).ResultsMore MCs were observed in NERD (7.23 ± 2.41 cells/HPF) as compared with controls (3.79 ± 1.67 cells/HPF) (P < 0.01) and the percentage of degranulated MCs in NERD was also significantly higher than controls (26.85 ± 8.79% vs 11.5 ± 4.18%, P < 0.01). Under TEM, more Golgi apparatus, mitochondria and endoplasmic reticulum were found in MCs in patients with NERD. Special secreting particles were also found in cytoplasm, more vacuoles were left after MCs degranulation in patients with NERD.ConclusionsOur results indicate that increased numbers of MCs and MCs activation may be involved in the pathogenesis of NERD.

show abstract

Section: Discussionmentioning

confidence: 99%