Incidence and Antibiotic Susceptibility Pattern of Staphylococcus spp. in Urinary Tract Infections (UTI), IRAN, 2013-2014

Erfani, Mohammad; Ghasemi, Dariush; Mirnejad, Reza; Piranfar, Vahhab

doi:10.3923/crb.2015.41.47

Cited by 1 publication

(3 citation statements)

References 18 publications

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“…It is noteworthy that all 15 S. aureus isolates tested were sensitive to amikacin, whereas only 13.33% were resistant to levofloxacin. The lack of resistance of S. aureus to amikacin obtained in our study is different from the high resistance profile reported in previous studies [ 24 ]. Therefore, according to the observed results, amikacin and levofloxacin could be alternative molecules in the treatment of UTIs caused by S. aureus in the studied population.…”

Section: Discussioncontrasting

confidence: 99%

“…On the other hand, the relatively low resistance rate of S. aureus was observed with amikacin and levofloxacin. Similarly, previous studies had also reported the high resistance of S. aureus against cefixime (80%) [24]. It is noteworthy that all 15 S. aureus isolates tested were sensitive to amikacin, whereas only 13.33% were resistant to levofloxacin.…”

Section: Discussionsupporting

confidence: 71%

“…It shows the highest prevalence of resistance was observed with two cephalosporins, cefazolin (100%) and cefixime (100%), followed by kanamycin (80.95%). Comparatively, the previous work reported a lower rate of resistance of S. saprophyticus to antibiotics: cefixime (90%), cefazolin (38%), and kanamycin (64%) [ 24 ]. Studies of the antimicrobial resistance profiles of Staphylococcus spp.…”

Section: Discussionmentioning

confidence: 97%

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Antibiotic Resistance Profile, Biofilm Formation Ability, and Virulence Factors Analysis of Three Staphylococcus spp. Isolates From Urine

Tsopmene¹,

Iwewe²,

Eyong³

et al. 2023

Cureus

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Background Staphylococcus spp . is one of the most causative agents of urinary tract infections (UTIs). This study aimed to investigate the antibiotic resistance profile and the virulence factors, including the biofilm formation ability of Staphylococcus spp. isolates from urine. Methodology The agar disk diffusion method was used to test the susceptibility of Staphylococcus isolates to ten antibiotics. The biofilm formation ability was determined using the safranin microplate-based method, and the phospholipase, esterase, and hemolysin activities were assessed by the agar plate method. Results During the study period, a prevalence of 18.12% of urinary tract infections caused by the identified Staphylococci was obtained. All the isolated Staphylococcus aureus and S. epidermidis were resistant to cefazolin. Multi-drug resistance (MDR) was recorded in 80.01%, 81.49%, and 76.20% of S. aureus , S. epidermidis, and S. saprophyticus isolates, respectively. Most of the isolates were moderate biofilm formers, while 44.44%, 31.75%, and 30.16% were positive for phospholipase, esterase, and hemolysin activities, respectively. No relevant correlations were observed between the ability of biofilm formation and the resistance to antibiotics or the expression of virulence factors investigated. Conclusion This study shows that Staphylococcus spp. isolates from patients with clinical manifestations of UTIs expressed a high degree of virulence factors, including the ability of biofilm formation, and exhibited multi-drug resistance to the majority of antimicrobials commonly used for the treatment of Staphylococcal infections.