Incidence and antibiotic susceptibility pattern of Staphylococcus aureus amongst patients with urinary tract infection (UTI) in UBTH Benin City, Nigeria

Abstract

Staphylococcus aureus is one of the most widely spread human pathogen. Considering the havoc it causes on life and subsequently on the economy, it became necessary to determine its incidence and antibiogram in our environment for adequate control and treatment. Records of microbial cultures and antibiotic sensitivity test results of suspected cases of urinary tract infection (UTI) of the University of Benin Teaching Hospital (UBTH) Benin City from January 1 st to 31 st December, 2005 were retrieved and statistically analyzed. Two thousand, one hundred and twelve (2,112) early morning mid-stream, urine samples were cultured and seven different microbial agents were isolated and identified. Staphylococuus aureus was found to be the most common organism isolated presenting 22.8%, closely followed by Klebsiella spp. (10.1%), Escherichia coli (8.2%), Proteus mirabilis (4.8%), Enteronacter spp. (4.4%), Pseudomonas aeruginosa (2.0%) and Candida albican (1.0%). No growth was recorded in 46.6% of cultures. The occurrence of S. aureus was found to be significantly higher (65.8%) in females compared to males (34.2%) (P>0.05). 35% of cases were observed between the ages of 21 to 30 years and the majority were female (46.7%). The S. aureus strains were sensitive to augmentin (83%), oxfloxacin (75.9%), nitrofurantion (63.5%) and gentamycine (50.2%). S. aureus was found to be highly resistant to tetracycline (80.9%), naladixic acid (79.3%) and contrimoxazole (87.3%). It was observed that S. aureus, among other organisms isolated, is the leading cause of UTI in our environment. Augmentin and oxfloxacin could be the drug of choice in the treatment of S. aureus.

Resistance Profiles of Staphylococcus aureus and Immunological Status in Pregnant Women at Bafang, West Region of Cameroon: A Cross-Sectional Study

“…This is in agreement with previous studies which had a similar finding [16,17]. However, the occurrence of 78.15% in pregnant women and 21.85% in non-pregnant women seen in our study was much higher than the 22.8% obtained by Akortha and Ibadin in 2008 [18].…”

Microbial Isolates from Urinary Tract Infection and their Antibiotic Resistance Pattern in Dhaka city of Bangladesh

“…In comparison to earlier studies, the current study (Akortha and Ibadin, 2008) revealed a significant increase in antibiotic resistance among microorganisms isolated from Bangladeshi patients. This may be the result of antibiotic misuse, the use of antibiotics from uncontrolled sources of production, such as those that are unknown to the user, the use of inactivated antimicrobials, antibiotic selection pressure, and a lack of quality control on some sources of antibiotics entering Bangladesh, particularly by the private sector.…”

Clinical, etiological and antimicrobial susceptibility profile of pediatric urinary tract infections in a tertiary care hospital of Nepal

“…A study conducted in Ireland concluded that 27.8% of S. aureus isolated from urine samples were MRSA [40]. Recent studies have reported the increasing prevalence of multi drug resistant S. aureus especially MRSA in UTIs [40, 41]. Among E. faecalis, 95% were resistant to amikacin, 69% to penicillin and 68% towards ofloxacin.…”