Incidence and aetiology of hydatidiform mole: An epidemiological review

Mb, Bracken

doi:10.1016/0020-7292(88)90168-3

Cited by 19 publications

(23 citation statements)

References 26 publications

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“…Increased maternal age is a strong risk factor for gestational trophoblastic diseases (GTD) (Bracken, 1987;Altieri et al, 2003), whereas the data about paternal age effects are conflicting. In a case-control study of 132 women with hydatiform mole (n ¼ 108) or choriocarcinoma (n ¼ 24), higher paternal age was associated with GTD after adjusting for maternal age.…”

Section: Gestational Trophoblast Diseasesmentioning

confidence: 99%

Paternal age and reproduction

Sartorius

Nieschlag

2009

Human Reproduction Update

289

212

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background: Due to various sociological factors, couples in developed countries are increasingly delaying childbearing. Besides ethical, economical and sociological issues, this trend presents us with several complex problems in reproduction. Although it is well-known that maternal age has a negative effect on fertility and increases the risk of adverse outcome during pregnancy and in offspring, the paternal influence on these outcomes is less well researched and not well-known.methods: We performed a systematic search of PubMed, and retrieved original articles and review articles to update our previous survey in this journal.results: This review highlights the link between male age and genetic abnormalities in the germ line and summarizes the knowledge about the effects of paternal age on reproductive function and outcome. Increasing paternal age can be associated with decreasing androgen levels, decreased sexual activity, alterations of testicular morphology and a deterioration of semen quality (volume, motility, morphology). Increased paternal age has an influence on DNA integrity of sperm, increases telomere length in spermatozoa and is suggested to have epigenetic effects. These changes may, at least in part, be responsible for the association of paternal age over 40 years with reduced fertility, an increase in pregnancy-associated complications and adverse outcome in the offspring. conclusion: Although higher maternal age can be an indication for intensive prenatal diagnosis, including invasive diagnostics, consideration of the available evidence suggests that paternal age itself, however, provides no rationale for invasive procedures.

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Section: Gestational Trophoblast Diseasesmentioning

confidence: 99%

Paternal age and reproduction

Sartorius

Nieschlag

2009

Human Reproduction Update

289

212

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“…Incidence in Asia is higher than in western countries. 1 The disease is more common in younger women and women nearing their end of reproductive period. 2 Current urine and serum pregnancy tests use antibodies directed against β hcg for immunologic identifications.…”

Section: Discussionmentioning

confidence: 99%

Negative Urine Pregnancy Tests in Gestational Trophoblastic Disease: A Diagnostic Dilemma

Ray¹,

Rakshit²,

Majumder³

et al. 2014

jemds

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ABSTRACT:Gestational trophoblastic disease is a broad disorder of abnormal fertilization of ovum. Early detection and treatment is the best approach to prevent mortality and morbidity of patients of gestational trophoblastic tumors. All trophoblastic cells produce hcg (human chorionic gonoadotropin) and can easily be detected in urine of pregnant ladies. When urine pregnancy test become negative in a highly suspected patient, the management becomes difficult. In this case, though the urine pregnancy tests were negative on several occasions, serum β hcg level was very high > 1500000 mIU/ml (positive) and patient was cured by chemotherapy.

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“…1 In 10 to 15% of cases, hydatidiform moles may develop into invasive moles. Cesarean scar pregnancy is a rare form of ectopic pregnancy with an incidence of 1:1800 to 1:2200 pregnancies.…”

Section: Introductionmentioning

confidence: 99%

Mole in the Hole: A Rare Case of Recurrent Invasive Vesicular Mole in an Ectopic Pregnancy at Scar Site with Bladder Invasion

Lewis¹,

Biswas²

2014

Journal of South Asian Federation of Obstetrics and Gynaecology

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Background: Cesarean scar pregnancy is a rare form of ectopic pregnancy with an incidence of 1:1800 to 1:2200 pregnancies. There is currently no consensus as to the most effective management of cesarean-scar ectopic pregnancy, and little is known about the outcome of subsequent pregnancies.Case report: We report here a very rare case of recurrent vesicular mole in an ectopic pregnancy at scar site with bladder invasion and its management. Conclusion:There is currently no consensus as to the most effective management of cesarean-scar ectopic pregnancy, and little is known about the outcome of subsequent pregnancies. We show that medical management was effective in this patient but further studies are needed to decide ideal management in such cases.

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Incidence and aetiology of hydatidiform mole: An epidemiological review

Cited by 19 publications

References 26 publications

Paternal age and reproduction

Paternal age and reproduction

Negative Urine Pregnancy Tests in Gestational Trophoblastic Disease: A Diagnostic Dilemma

Mole in the Hole: A Rare Case of Recurrent Invasive Vesicular Mole in an Ectopic Pregnancy at Scar Site with Bladder Invasion

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