Inbred mouse strains vary in oral self-selection of nicotine

Robinson, Scott B.; Marks, Michael J.; Collins, Allan C.

doi:10.1007/bf02247438

Cited by 125 publications

(155 citation statements)

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“…C57BL/6Ibg mice exhibited greater oral nicotine self-administration than DBA/2Ibg, ST/bJ, BUB/J, A/Ibg, and C3H/2Ibg mice [140]. Furthermore, C57BL/6J mice developed nicotine CPP, whereas DBA/2J mice did not [60].…”

Section: The Effects Of Nicotine In Inbred Rodent Strainsmentioning

confidence: 87%

Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: Converging evidence from human and animal research

Portugal

Gould

2008

Behavioural Brain Research

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Tobacco smoking is a leading preventable cause of death in the United States and produces a major health and economic burden. Although the majority of smokers want to quit, few are successful. These data highlight the need for additional research into the neurobiology of tobacco dependence. Addiction to nicotine, the main psychoactive component of tobacco, is influenced by multiple factors that include individual differences in genetic makeup. Twin studies have demonstrated that genetic factors can influence vulnerability to nicotine addiction, and subsequent research has identified genes that may alter sensitivity to nicotine. In humans, genome-wide and candidate gene association studies have demonstrated that genes encoding nicotinic acetylcholine receptor (nAChR) proteins are associated with multiple smoking phenotypes. Similarly, research in mice has provided evidence that naturally occurring variability in nAChR genes is associated with changes in nicotine sensitivity. Furthermore, the use of genetic knockout mice has allowed researchers to determine the nAChR genes that mediate the effects of nicotine, whereas research with knockin mice has demonstrated that changes to nAChR genes can dramatically alter nicotine sensitivity. This review will examine the genetic factors that alter susceptibility to nicotine addiction, with an emphasis on the genes that encode nAChR proteins.

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Section: The Effects Of Nicotine In Inbred Rodent Strainsmentioning

confidence: 87%

Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: Converging evidence from human and animal research

Portugal

Gould

2008

Behavioural Brain Research

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“…As a consequence, the preference for the drug solution and its taste did not vanish. A broader range of nicotine concentrations should perhaps have been studied, since apparent drug peculiarities could also be dosespecific (Smith and Roberts 1995;Meliska et al 1995;Robinson et al 1996).…”

Section: Discussionmentioning

confidence: 99%

“…To obtain the faded-out solutions, the initial solution was diluted with tap water. Nicotine concentrations were selected on the basis of literature data (Meliska et al 1995;Robinson et al 1996;Adriani et al 2002). …”

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confidence: 99%

“…Nicotine's effects in mice have been shown to be highly dependent on the genetic background (see Marks et al 1989;Robinson et al 1996). However, the interaction between the pharmacological effects and the incentive properties of nicotine during the adolescent period has been largely neglected in basic research.…”

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confidence: 99%

“…The nicotine solutions generally fail to be preferred to water in this paradigm when the two bottles are left continously available 24 h per day (Le Houezec et al 1989;Flynn et al 1989). Results are negative in various rat and mouse strains, even when attempts have been made to try to mask the NIC bitter taste by means of a sweetened solution as a vehicle (Smith and Roberts 1995;Meliska et al 1995;Robinson et al 1996). A very recent study provided however evidence that a clear-cut preference for the nicotine bottle can be established in mice adapted to a water-deprivation schedule, and given a 2-h daily access to the two bottles (Adriani et al 2002).…”

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confidence: 99%

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Peculiar Vulnerability to Nicotine Oral Self-administration in Mice during Early Adolescence

Adriani

Macrı̀

Pacifici

et al. 2002

Neuropsychopharmacology

194

142

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(10 mg/l). After a 6-day period, a fading study was carried out, in which nicotine concentration was reduced to 7 mg/l (days 7-9) and 5 mg/l (days 10-12), to assess whether animals would compensate by increasing their intake from the nicotine solution. In Experiment 2, psychopharmacological effects on locomotion induced by the nicotine solution (0, 10, 30 mg/l) Recent research has emphasized that adolescence is associated with patterns of temporary deviance (Arnett 1992) and the use of various kinds of psychoactive agents (Mathias 1996). Drug abuse in adolescents ranging from 11-12 to 17-18 years of age is likely to start with tobacco smoking, which can be followed by marijuana and/or 1991;Breslau et al. 1993;Nides et al. 1995;Kandel and Chen 2000). Despite the social and scientific importance of deepening our knowledge of this issue (see e.g. Colby et al. 2000), there have been very few investigations on the psychobiological factors contributing to the specific adolescence-related willingness to experience various psychoactive drugs (for a review, see Laviola et al. 1999;Spear 2000). For the purpose of laboratory studies, a suitable animal model of human adolescence is available in rodents. Namely, periadolescence is classically defined as the ontogenetic period that encompasses the week preceding the onset of puberty and the first few days thereafter (Spear and Brake 1983). Periadolescent rodents differ markedly from adults in their spontaneous behavioral repertoire (Cirulli et al. 1996;Terranova et al. 1993;Meaney and Stewart 1981;Panksepp 1981). In fact, elevated levels of novelty seeking and a reduced behavioral and hormonal response to stress (Adriani et al. 1998;Adriani and Laviola 2000) are exhibited by animals around this age. A characteristic hyporesponsivity to the effects of an acute administration of psychostimulants (Spear and Brake 1983;Laviola et al. 1995;Bolanos et al. 1998;Adriani and Laviola 2000), a peculiar pattern of behavioral sensitization following repeated drug exposure (Laviola et al. 1995(Laviola et al. , 2001Adriani et al. 1998), as well as a weak drug-induced place conditioning profile (Adriani et al. 1998;Bolanos et al. 1996Bolanos et al. , 1998 but see Campbell and Spear 2000), are also reported. Based on these findings, an increased vulnerability to the addictive properties of abused drugs has been suggested to be typical of adolescence in both humans and animals models (see Laviola et al. 1999).In the present study, we were interested in nicotine, which beside being the main psychoactive compound implied in tobacco smoking, also shares most of the characteristics of other addictive drugs (Corrigall et al. 1992(Corrigall et al. ,1994Pontieri et al. 1996;Merlo-Pich et al. 1997;Stolerman 1999). Nicotine's effects in mice have been shown to be highly dependent on the genetic background (see Marks et al. 1989;Robinson et al. 1996). However, the interaction between the pharmacological effects and the incentive properties of nicotine during the adolescent period has been largel...

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Tobacco Dependence

Swan

Hudmon

Khroyan

2003

Handbook of Psychology

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Tobacco dependence results in an estimated 430,000 premature deaths and $72 billion in related costs per year in the United States. This chapter takes a multidisciplinary approach to reviewing the problem of tobacco dependence. Findings from preclinical animal studies of the neurobiology of nicotine and its reinforcing effects have been integrated with human clinical and population studies examining sex and ethnic differences, cognitive effects, various environmental risk factors, complex genetic traits, and prevention and cessation methods for tobacco dependence. In many respects, examination of social, behavioral, and genetic risk factors in humans has developed independently from basic animal research. Fortunately, there has been a greater collaboration and exchange of findings between the human and animal fields of research, prompted mainly by significant progress at the molecular genetic level. For example, present and future research is addressing the following important issues: the study of nicotine pharmacokinetics and gene‐environment interactions in families as they relate to tobacco dependence; the examination of gene‐environment interactions in the development and maintenance of nicotine addiction in well‐controlled conditions using animal models; and the extent to which genetic variation influences response to treatment for tobacco dependence. These converging lines of research will lead to an improved understanding of the complexities of tobacco dependence and its treatment.

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Inbred mouse strains vary in oral self-selection of nicotine

Cited by 125 publications

References 48 publications

Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: Converging evidence from human and animal research

Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: Converging evidence from human and animal research

Peculiar Vulnerability to Nicotine Oral Self-administration in Mice during Early Adolescence

Tobacco Dependence

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