Inavtivation of trypsin by antibodies of high affinity

Binding of 125I-Labeled Proteinases to Plasma Proteins in Cystic Fibrosis

“…It has been demonstrated that rabbit antibodies against trypsin inhibit the activity of the enzyme toward both high and low molecular weight substrates (I). Their affinity for trypsin increases with prolonged immunization and is proportional to their inhibitory capacity (10). The level of immunoreactive trypsin, which cannot be distinguished from trypsinogen by radioimmunoassay (2, 1 I), is considerably decreased in plasma of patients affected with chronic pancreatitis (9).…”