Inapparent Congenital Cytomegalovirus Infection with Elevated Cord IgM Levels

Dw, Reynolds; Stagno, Sergio; Kg, Stubbs; Aj, Dahle; Mm, Livingston; Ss, Saxon; Ca, Alford

doi:10.1056/nejm197402072900601

Cited by 230 publications

(67 citation statements)

References 16 publications

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“…In man they may be responsible for congenital and neonatal infections (Stern et al, 1969;Reynolds et al, 1973Reynolds et al, , 1974, a variety of clinical syndromes in children and adults (Diosi & Rosin, 1965;Klemola & K~ifirifiinen, 1965;Carter, 1968;Henson, 1969;Klemola et al, 1969;Craighead, 1971;Weller, 1971a, b), acquired immune deficiency (Duwall et al, 1966;Rinaldo et al, 1980;Drew et al, 1981 ;Mildvan et al, 1982), and may complicate organ transplantation (Craighead et al, 1967;Spencer, 1974) and" open heart surgery (Kfi~iri~tinen et al, 1966;Lang et al, 1968;Caul et al, 1971).…”

Section: Introductionmentioning

confidence: 99%

An Ultrastructural Investigation of Cytomegalovirus Replication in Murine Hepatocytes

Papadimitriou¹,

Shellam

Robertson³

1984

Journal of General Virology

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SUMMARYThe morphological characteristics of murine cytomegalovirus replication in murine hepatocytes were investigated by electron microscopy and structural evidence of an unusual mode of virus maturation was detected. Nucleocapsids form in the nucleus; those with electron-dense cores bud into the perinuclear cisternae and acquire an outer envelope from the inner membrane of the nuclear envelope. Viral envelopes fuse with the outer membrane of the nuclear envelope releasing nucleocapsids in the paranuclear zone where they aggregate and form cytoplasmic inclusions. These inclusions are invariably surrounded by lamellae and vesicles of the Golgi complex into which nucleocapsids again bud. Virions, now covered with a new membrane envelope, are transported within secondary lysosomes and released by emiocytosis into the extraceUular space.

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Section: Introductionmentioning

confidence: 99%

An Ultrastructural Investigation of Cytomegalovirus Replication in Murine Hepatocytes

Papadimitriou¹,

Shellam

Robertson³

1984

Journal of General Virology

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“…It has been reported that approximately 1 % of the newborns are infected by human CMV and at least 10% of the infected neonates suffer damage to the central nervous system (3,5,11,14). These facts have drawn much attention to development of CMV vaccines (2,9,10).…”

mentioning

confidence: 99%

Murine Model for Immunoprophylaxis of Cytomegalovirus Infection

Minamishima

Eizuru

Yoshida

et al. 1978

Microbiology and Immunology

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Murine cytomegalovirus was utilized as a model for human cytomeglovirus, which had no experimental animal, to study immunoprophylaxis of the cytomegalovirus infections.( 1) Murine cytomegalovirus (MCMV) serially propagated in mouse embryonic fibroblasts had lost pathogenicity for weanling mice including neonatally thymectomized mice.(2) The cell culture-adapted MCMV was effective as a "live, attenuated virus vaccine" against challenge by virulent, mouse-passaged MCMV.(3) The immunization via intraperitoneal route protected mice from every parameter of MCMV infection. These included clinical signs, virus replication, histopathology and mortality.(4) The protective immunity was active against the virulent MCMV which was not neutralized by the rabbit anti-attenuated MCMV serum.Cytomegalovirus (CMV), a member of the Herpetoviridae, is ubiquitous in human population. It has been reported that approximately 1 % of the newborns are infected by human CMV and at least 10% of the infected neonates suffer damage to the central nervous system (3,5,11,14). These facts have drawn much attention to development of CMV vaccines (2, 9, 10). However, since the human CMV is highly species-specific and has no experimental animal, pathogenicity of the CMV and immunity to the CMV infection have remained poorly understood.To solve this problem, we have employed murine CMV (MCMV) (7) which simulates the human CMV with regard to pattern of infection, except for transplacental infection (4). In addition, since the MCMV is attenuated by in vitro passages and the attenuated MCMV is immunogenic for mice (8), the MCMV system is expected to provide a model for immunoprophylaxis of the CMV infection in human (6). This paper is concerned with effect of prior immunization with a live attenuated MCMV (CC-MCMV) on mortality, clinical signs, virus replication, and histopathological changes in mice subsequently challenged with a virulent MCMV (SG-MCMV).693

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“…As larger groups of infected infants are carefully observed for longer periods of time we are beginning to get some idea of the long term consequences of fetal or neonatal infection. The report of Reynolds et al (16) is not conclusive but does suggest that infection may result in some retardation of mental development and/or auditory loss. They estimate that the frequency of some impairment may be as high as 1 in every 1,000 live births.…”

Section: CMVmentioning

confidence: 91%

“…I will not attempt a complete review of the subject of CMV infection but rather will emphasize what has been required t o get a reasonable estimate of the true long term consequences of congenital or perinatal CMV infection. Several prospective studies have been conducted enrolling women as early in pregnancy as possible and testing for CMV antibodies and virus excretion (10,15,16). Their infants have been evaluated at regular intervals for CMV infection and examined for any abnormalities that might be ascribed t o the infection.…”

Section: CMVmentioning

confidence: 99%

The Long Term Effects of Infection in Early Life (Long View II): Presidential Address delivered at the Symposium on the Long Term Effects of Events in Early Life, American Pediatric Society Annual Meeting, May 1, 1974, Washington, D.C.

Robbins

1974

Pediatr Res

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Inapparent Congenital Cytomegalovirus Infection with Elevated Cord IgM Levels

Cited by 230 publications

References 16 publications

An Ultrastructural Investigation of Cytomegalovirus Replication in Murine Hepatocytes

An Ultrastructural Investigation of Cytomegalovirus Replication in Murine Hepatocytes

Murine Model for Immunoprophylaxis of Cytomegalovirus Infection

The Long Term Effects of Infection in Early Life (Long View II): Presidential Address delivered at the Symposium on the Long Term Effects of Events in Early Life, American Pediatric Society Annual Meeting, May 1, 1974, Washington, D.C.

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