“…Previous studies have shown GaN to be stable in even harsh conditions, and no signicant leaching over a 2 days period. 25,33 This study, up to this point, has largely ignored the cellular mechanics and processes which might be involved in cellular stimulation while instead focusing on the material's properties (PPC, doping, chemistry, etc.). It is important to note however that both, intracellular ROS production and calcium release are important intracellular signaling molecules, which are present in various organelles in the cell, and oen have either self-amplifying or deteriorative relationships depending on not only the organelle function, but also the metabolic state of the cell.…”