“…Inadvertent transmural injection of India ink for tattoing is not uncommon and can result in a host of adverse events. 3 What we refer to as postpolypectomy syndrome, attributed to a transmural burn from electrocoagulation, may as much be due to extramural injection. When present, the lifting sign may not be a reliable indicator of injection into the submucosal layer; injection into the connective tissue space between the circular and longitudinal muscle layers may cause lifting of the circular layer, with subsequent risk of snare capture of this layer.…”