Inadvertent pregnancy during ustekinumab therapy in a patient with plaque psoriasis and impetigo herpetiformis

An effective and promising treatment with adalimumab for impetigo herpetiformis with postpartum flare-up

“…Unlike in the case of GPP, however, there have been only a few reports on the effectiveness of biologics for IH . In conclusion, adalimumab may be an effective and promising treatment for IH with postpartum flare‐up.…”

Pregnancy during Ustekinumab Treatment for Severe Psoriasis

“…The second reported exposure during the third trimester of pregnancy and the child had normal development up to 9 months, when she had her last update, based on the mother's information [2]. More recently two additional reports were published, both with uncomplicated pregnancies [3,4]. According to unpublished data from clinical studies until June 2010, 42 maternal exposures were identified during trials of ustekinumab, but only 10 had adequate results registered [14].…”

“…It is the most recent biologic agent approved in Brazil for the treatment of psoriasis. There are four reports describing pregnancy during ustekinumab treatment, one resulting in miscarriage and the others with normal gestational evolution [1,2,3,4]. Many women under treatment with biologic agents are of childbearing age, and previous studies have shown that these women have increased risks of adverse pregnancy outcomes and labor and/or delivery complications compared to the general population [5,6].…”

Treating Psoriasis During Pregnancy: Safety and Efficacy of Treatments

“…There are very limited data on the safety of ustekinumab treatment during pregnancy. The literature only holds case reports [108][109][110][111], all resulting in healthy babies. One report has pooled data from 4 years of clinical trials with 31 pregnancies, with no incidence of fetal malformations or death [111].…”