Inadequate prescription of chronic consumption of proton pump inhibitors in a hospital in Mexico: Cross-sectional study

Sánchez-Cuén, Jaime Alberto; Irineo-Cabrales, Ana Bertha; Bernal-Magaña, Gregorio; Peraza-Garay, Felipe de Jesús

doi:10.4321/s1130-01082013000300003

Cited by 17 publications

(15 citation statements)

References 34 publications

(27 reference statements)

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“…By comparing patients according to their site of care, the inappropriateness of PPIs prescription was much higher in non-ICU patient compared to ICU patients (87.4 % versus 52.4 %, respectively). Several previous studies reached a similar conclusion and have shown that there was an overuse of PPIs in different clinical settings [10,15,[20][21][22]. Two studies conducted in a major teaching hospital in Tasmania and United kingdom, showed that inappropriate prescription of PPIs were around 60.4 % and 56.0 %, respectively [10,20].…”

Section: Discussionsupporting

confidence: 53%

See 1 more Smart Citation

Inappropriate prescribing of proton pump inhibitors among patients in two Jordanian tertiary health facilities

Zalloum¹,

Farha²,

Awwad³

et al. 2016

Trop. J. Pharm Res

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Section: Discussionsupporting

confidence: 53%

“…More recently, it was demonstrated that 61 % of patients admitted to four different hospitals in the state of Maryland received PPIs improperly [15]. In Mexico, the prescription of PPIs was inappropriate in just 35.5 % of the cases [21].…”

Section: Discussionmentioning

confidence: 99%

Inappropriate prescribing of proton pump inhibitors among patients in two Jordanian tertiary health facilities

Zalloum¹,

Farha²,

Awwad³

et al. 2016

Trop. J. Pharm Res

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show abstract

“…PPIs is a relatively safe type of acid suppression preparations, but overuse can also cause electrolyte metabolism disorders such as calcium and magnesium [7], and increase the risk of infection and other adverse consequences [8], which should be paid enough attention. Indications for the use of drugs for digestive tract gastric acid-related diseases are not accurate enough, which may lead to therapeutic abuse of PPIs [9]. Fear of gastrointestinal bleeding, lack of attention to side effects of acid suppression, and unfamiliar indications for emergency ulcer prevention are the main causes of preventive abuse of PPIs [10].…”

Section: Discussionmentioning

confidence: 99%

Investigation on Intervention Effects of Applying Proton Pump Inhibitors in Inpatients

Qing

Wei

et al. 2019

Preprint

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Background. To investigate the intervention effect of clinical pharmacists on irrational use of proton pump inhibitors (PPIs) in clinicians. Methods. A cross-sectional study was used to through the hospital information management system survey, before intervention (July 15th, 2016, Aug 15th, 2016 and Sep 15th 2016) and dry prognosis (July 15th, 2017, Aug 15th, 2017 and Sep 15th, 2017) all the use of PPIs inpatients related information. According to the guidelines of "drug instructions" and "experts on stress ulcer prevention and treatment experts", the standard of drug use was formulated, and the use of PPIs before and after intervention was evaluated and analyzed in accordance with the standard, and the results of intervention were evaluated. Results. The total number of hospitalized patients surveyed before the intervention was 1,693, the average utilization rate of proton pump inhibitors was 27.05% and the coincidence rate was 52.40%. The total number of hospitalized patients investigated after the intervention was 2,095, the average utilization rate of proton pump inhibitors was 8.54%, and the coincidence rate was 68.16%. Before and after the intervention, there was no difference in gender ratio and age distribution, the decrease of the utilization rate and the improvements of the qualified rate after intervention were statistically significant.Conclusion. According to the standards of PPIs, clinical pharmacists strictly implement the special prescription review system and other intervention measures, which can significantly improve the level of PPIs rational clinical medication.

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“…The overuse of PPIs has been demonstrated in several studies (10)(11)(12). In a study conducted at the Hospital de Guadalajara, Martín-Echevarría et al found that among patients taking PPIs at admission, 73% had an inadequate indication and 38% of patients were discharged with this medication even without correct indication (13).…”

Section: Overuse and Its Consequencesmentioning

confidence: 99%

Practical considerations in the management of proton-pump inhibitors

Aguilera¹,

Martín-de-Argila-dePrados²,

Albillos-Martínez³

2015

Rev Esp Enferm Dig

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Proton-pump inhibitors (PPIs) are one of the most active ingredients prescribed in Spain. In recent decades there has been an overuse of these drugs in both outpatient clinics and hospitals that has lead to a significant increase in healthcare spending and to an increase in the risk of possible side effects. It is important for health professionals to know the accepted indications and the correct doses for the use of these drugs. On the market there are different types of PPI: omeprazole, pantoprazole, lansoprazole, rabeprazole and esomeprazole. Omeprazole is the oldest and most used PPI, being also the cheapest. Although there are no important differences between PPIs in curing diseases, esomeprazole, a newgeneration PPI, has proved to be more effective in eradicating H. pylori and in healing severe esophagitis compared to other PPIs. In recent years the use of generic drugs has spread; these drugs have the same bioavailability than the original drugs. In the case of PPIs, the few comparative studies available in the literature between original and generic drugs have shown no significant differences in clinical efficacy.Key words: Proton-pump inhibitor. PPI. Omeprazole. Pantoprazole. Lansoprazole. Rabeprazole. Esomeprazole. INTRODUCTIONProton-pump inhibitors (PPIs) represent a family of drugs widely used in our country. The advent in the nineties of PPIs was a great revolution in the treatment of ulcer disease and gastroesophageal reflux. The main problems of PPIs at present time are its overuse and the errors in the therapeutic indication. This fact leads to a considerable health economic cost and the risk of long-term side effects. In this review the main problems of PPIs prescription, their indications, the differences between PPIs and tips on their use are discussed. Brief historical memory: since alkaline diets until PPIsThe treatment of ulcer disease and gastroesophageal reflux disease (GERD) in the early twentieth century was the prescription of alkaline foods like milk, eggs and puree (1). Later, there were products as sodium bicarbonate that improved symptoms but did not prevent complications. Surgical treatment consisted of different types of gastric surgeries for peptic ulcer disease and Nissen fundoplication for GERD (2).In the mid twentieth century the use of muscarinic antagonists was introduced, atropine being its main active ingredient. Acids secretion was partially inhibited by blocking the muscarinic receptor of the parietal cell. However, these drugs had little effectiveness and numerous adverse effects due to the amount of muscarinic receptors distributed throughout the body. E-type prostaglandin was discovered later, but, again, the limitations of these substances were their short half life and side effects. An important progress in gastric antisecretory therapy was the appearance of H 2 receptors antagonists (H 2 blockers) (3). The most used were ranitidine and famotidine. These drugs established a substantial change by blocking the action of histamine receptor in gastric parietal ...

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Inadequate prescription of chronic consumption of proton pump inhibitors in a hospital in Mexico: Cross-sectional study

Abstract: the frequency of inappropriate prescriptions of chronic use of PPIs was high, around 35.3 %, similar to those reported in hospitals in developed countries.

Cited by 17 publications

References 34 publications

Inappropriate prescribing of proton pump inhibitors among patients in two Jordanian tertiary health facilities

Inappropriate prescribing of proton pump inhibitors among patients in two Jordanian tertiary health facilities

Investigation on Intervention Effects of Applying Proton Pump Inhibitors in Inpatients

Practical considerations in the management of proton-pump inhibitors

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