Inactive renin of human plasma is a circadian variable

Cugini, P; Salandi, E.; Murano, G; Centanni, Marco; Scavo, D

doi:10.1016/0006-2944(83)90014-5

Cited by 2 publications

(3 citation statements)

References 21 publications

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“…Because of this physiological linkage, it must be stressed that prorenin, plasma renin activity (PRA) and plasma aldosterone (PA) are biochemical variables whose levels fluc tuate with a systematic periodicity along the 24-hour span [8][9][10]. The hypothesis that ACE itself might be a biorhythmic variable oscillating with a circadian (about 24 h) pe riodicity may therefore be tentatively sug gested.…”

Section: Introductionmentioning

confidence: 99%

The Circadian Rhythm of Serum Angiotensin-Converting Enzyme Is Disrupted in Ascitic Liver Cirrhosis

Cugini

Letizia²,

Lucia³

et al. 1989

Enzyme

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An increase in morning fasting levels of plasma (P) renin activity (RA), aldosterone (A) and serum (S) angiotensin-converting enzyme (ACE) activity has been demonstrated in ascitic cirrhotic patients (ACP). Since both PRA and PA change biorhythmically in their time structure, the relationship of SACE activity with the components of the reninangiotensin- aldosterone system (RAAS) was investigated in clinically healthy subjects (CHS) and ACP. Time-qualified data were chronobiologically analysed by means of the cosinor procedure to resolve and quantify the circadian rhythm (CR). The 24-hour mean levels of PRA, PA and SACE activity were found to be elevated in ACP as compared to CHS. The temporal variability of these analytes was found to be of periodic type along the 24-hour span in CHS, but not in ACP. The well-organized cyclicity in CHS is of relevant interest. PRA and PA cycles were found to phase in a clear antiparallelism with the SACE activity CR. The phase opposition may be, speculatively, related to the physiologic nature of ACE, whose activity is devoted to generate angiotensin II. The disappearance of SACE activity CR in ACP is in accordance with the abolition of PRA and PA cyclicity and suggests a role of liver in regulating the periodic time function of the RAAS and related components.

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Section: Introductionmentioning

confidence: 99%

The Circadian Rhythm of Serum Angiotensin-Converting Enzyme Is Disrupted in Ascitic Liver Cirrhosis

Cugini

Letizia²,

Lucia³

et al. 1989

Enzyme

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“…This first demonstration has a speculative importance under an endocrinological point of view. Previous studies have described that the function of the RAAS is periodic along the 24-hour span (Gordon et al 1966;Vagnucci et al 1974;Armbruster et al 1975;Katz, Romph and Smith 1975;Modlinger et al 1976;Cugini et al 1980;Cugini et al 1983;Kawasaki et al 1980;Kawasaki et al 1983). Such a periodicity was assumed by taking into consideration the enzymatic activity of plasma renin.…”

Section: Discussionmentioning

confidence: 99%

“…The circadian rhythmicity also attains to prorenin, the precursor of active renin {Cugini, Salandi, Murano, Centanni and Scavo 1983). In the recent past, the determination of circulating prorenin was carried out via an indirect estimate according to the technique called cryoactivation {Sealey, Moon, Laragh and Alderman 1976).…”

Section: Introductionmentioning

confidence: 99%

Circadian Variations of Total Renin, Active Renin, Plasma Renin Activity and Plasma Aldosterone in Clinically Healthy Young Subjects

et al. 1990

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The direct assay of total renin (TRC) and active renin concentration (ARC) is a reality due to the availability of monoclonal antibodies against human renin. Because of this, a study has been performed in order to assess the circadian rhythmicity of TRC and ARC. The study was extended to plasma renin activity (PRA) and plasma aldosterone concentration (PAC) for a more complete assessment of the renin-angiotensin-aldosterone system (RAAS). Twelve clinically healthy subjects (6 males and 6 females, age from 20 to 25 years) volunteered for this study. Time-qualified data series were analysed by means of chronobiological procedures in order to validate the circadian rhythm and to correlate the sinusoidal profiles. The circadian rhythm was validated at a high significance for TRC, ARC, PRA and at a borderline significance for PAC. The periodic oscillations were significantly correlated, demonstrating that TRC, ARC, PRA and PAC cycles oscillate in synchronism during the 24-hour span.

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Inactive renin of human plasma is a circadian variable

Cited by 2 publications

References 21 publications

The Circadian Rhythm of Serum Angiotensin-Converting Enzyme Is Disrupted in Ascitic Liver Cirrhosis

The Circadian Rhythm of Serum Angiotensin-Converting Enzyme Is Disrupted in Ascitic Liver Cirrhosis

Circadian Variations of Total Renin, Active Renin, Plasma Renin Activity and Plasma Aldosterone in Clinically Healthy Young Subjects

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