Inactive Matrix Gla-Protein and Arterial Stiffness in Type 2 Diabetes Mellitus

Sardana, Mayank; Vasim, Izzah; Varakantam, Swapna; Kewan, Uzma; Tariq, Ali; Koppula, Maheshwara Reddy; Syed, Amer Ahmed; Beraun, Melissa; Drummen, Nadja E.A.; Vermeer, Cees; Akers, Scott; Chirinos, Julio A.

doi:10.1093/ajh/hpw146

Cited by 47 publications

(27 citation statements)

References 29 publications

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“…In a variety of patients, dp-ucMGP was strongly increased (which is consistent with the increased disease risk of elevated dp-ucMGP in the general population) as reported by Mayer [33][34][35], Ueland [36,37] and others [38][39][40][41][42]. Increasing levels of dp-ucMGP were also found to represent a strong risk for all-cause mortality.…”

Section: Comments On the Draft Efsa Scientific Opinion On Dietary Refsupporting

confidence: 85%

Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for vitamin K

2017

EFSA Supporting Publications

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The European Food Safety Authority (EFSA) carried out a public consultation to receive input from the scientific community and all interested parties on the draft Scientific Opinion on Dietary Reference Values (DRVs) for vitamin K, prepared by the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA Panel) and endorsed by the Panel for public consultation at its Plenary meeting on 25 October 2016. The written public consultation for this document was open from 13 January to 24 February 2017. EFSA received comments from 10 interested parties. EFSA and its NDA Panel wish to thank all stakeholders for their contributions. The current report summarises the outcome of the public consultation, and includes a brief summary of the comments received and how the comments were addressed. The NDA Panel prepared an updated version of the Scientific Opinion on Dietary Reference Values for vitamin K, taking into account the comments received. The Scientific Opinion was discussed and adopted at the NDA Plenary meeting on 5 April 2017, and is published in the EFSA Journal.

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Section: Comments On the Draft Efsa Scientific Opinion On Dietary Refsupporting

confidence: 85%

Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for vitamin K

2017

EFSA Supporting Publications

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“…Justifiably, the investigators evaluated the validity of their modeling approach by observing that the data in the hypertensive group was well represented by a simpler model (i.e., with fewer parameters; also see Local minima and overfitting). The model complexity/ overfitting consideration was a major aspect of our study that 702012 Heart failure cfPWV Fibulin-1 Laugesen et al 762013 Diabetes cfPWV Fibulin-1 Mayer et al (90) 2016 General population cfPWV MGP Pivin et al (101) 2015 Family population cfPWV MGP Sardana et al (107) 2017 Diabetes cfPWV MGP Thamratnopkoon et al 139 AGE, advanced glycation end product; cfPWV, carotid-femoral pulse wave velocity (PWV); ␤-PWV, PWV calculated from stiffness index ␤; cPWV, carotid PWV; cDC, carotid distensibility coefficient; baPWV, brachial-ankle PWV; COL1A1, collagen type I ␣1; COL4A1, collagen type IV ␣1; COL3A1, collagen type III ␣1. , Level(s) at which a study assessed arterial stiffening.…”

Section: Content Analysis Of Selected Papersmentioning

confidence: 90%

Constitutive interpretation of arterial stiffness in clinical studies: a methodological review

Reesink

Spronck

2019

American Journal of Physiology-Heart and Circulatory Physiology

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Clinical assessment of arterial stiffness relies on noninvasive measurements of regional pulse wave velocity or local distensibility. However, arterial stiffness measures do not discriminate underlying changes in arterial wall constituent properties (e.g., in collagen, elastin, or smooth muscle), which is highly relevant for development and monitoring of treatment. In arterial stiffness in recent clinical-epidemiological studies, we systematically review clinical-epidemiological studies (2012–) that interpreted arterial stiffness changes in terms of changes in arterial wall constituent properties (63 studies included of 514 studies found). Most studies that did so were association studies (52 of 63 studies) providing limited causal evidence. Intervention studies (11 of 63 studies) addressed changes in arterial stiffness through the modulation of extracellular matrix integrity (5 of 11 studies) or smooth muscle tone (6 of 11 studies). A handful of studies (3 of 63 studies) used mathematical modeling to discriminate between extracellular matrix components. Overall, there exists a notable gap in the mechanistic interpretation of stiffness findings. In constitutive model-based interpretation, we first introduce constitutive-based modeling and use it to illustrate the relationship between constituent properties and stiffness measurements (“forward” approach). We then review all literature on modeling approaches for the constitutive interpretation of clinical arterial stiffness data (“inverse” approach), which are aimed at estimation of constitutive properties from arterial stiffness measurements to benefit treatment development and monitoring. Importantly, any modeling approach requires a tradeoff between model complexity and measurable data. Therefore, the feasibility of changing in vivo the biaxial mechanics and/or vascular smooth muscle tone should be explored. The effectiveness of modeling approaches should be confirmed using uncertainty quantification and sensitivity analysis. Taken together, constitutive modeling can significantly improve clinical interpretation of arterial stiffness findings.

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“…Liabeuf et al indicated that higher dp-ucMGP was significantly associated with a higher odds of peripheral arterial calcification score: odds ratio 1.88 (1.14, 3.11) [ 24 ]. Higher plasma dp-ucMGP was consistently associated with higher carotid-femoral pulse wave velocity (cf-PWV) in populations from different countries [ 25 – 27 ]. In the MESA study, no association between circulating DCP and cardiovascular calcification was observed in healthy participants [ 17 ].…”

Section: Circulating Vitamin K and Cvd-related Outcomesmentioning

confidence: 99%

The Role of Vitamin K Status in Cardiovascular Health: Evidence from Observational and Clinical Studies

Ballegooijen

Beulens

2017

Curr Nutr Rep

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Purpose of ReviewVitamin K is a fat-soluble vitamin required for the activation of several vitamin K-dependent proteins to confer functioning. A growing body of evidence supports that vitamin K has beneficial effects on bone and cardiovascular health. This review summarizes key evidence on vitamin K status as measured by circulating measures and cardiovascular outcomes.Recent FindingsOverall, observational studies indicate that low vitamin K status as measured by high dephosphorylated uncarboxylated matrix gla protein concentrations plays a potential role in cardiovascular disease development, particularly in high-risk and chronic kidney disease populations. Very few vitamin K intervention trials have been conducted with cardiovascular-related outcomes. A couple of intervention trials studied the effect of the combination of vitamin D + K supplementation, which might have synergistic effects compared to vitamin K supplementation alone.SummaryAssessing vitamin K status in prospective studies and well-designed randomized trials would provide important insight whether vitamin K is causally related to vascular calcification and cardiovascular disease.

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Inactive Matrix Gla-Protein and Arterial Stiffness in Type 2 Diabetes Mellitus

Cited by 47 publications

References 29 publications

Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for vitamin K

Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for vitamin K

Constitutive interpretation of arterial stiffness in clinical studies: a methodological review

The Role of Vitamin K Status in Cardiovascular Health: Evidence from Observational and Clinical Studies

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