“…During follicle development, Wt1 is expressed at high levels in granulosa cells of primordial, primary, and secondary follicles, but its expression is decreased in antral follicles, suggesting that it might be a repressor of ovarian differentiation genes in the granulosa cells ( Hsu et al, 1995 ). Our previous studies demonstrated that Wt1 is required for the lineage specification and maintenance of Sertoli and granulosa cells ( Cen et al, 2020 ; Chen et al, 2017 ). However, the underlying mechanism that regulates the expression of Wt1 in granulosa cells is unknown.…”